Výsledky vyhledávání - "William, Grey"

Akademický článek

The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function

Autor: William Grey, Samantha Atkinson, Beatrice Rix, Pedro Casado, Linda Ariza-McNaughton, Cathy Hawley, Miriam L. Sopoena, Katherine S. Bridge, David Kent, Pedro R. Cutillas, Dominique Bonnet

Publikováno v: HemaSphere, Vol 7, Iss 3, p e853 (2023)

Long-term hematopoietic stem cells are rare, highly quiescent stem cells of the hematopoietic system with life-long self-renewal potential and the ability to transplant and reconstitute the entire hematopoietic system of conditioned recipients. Most

Externí odkaz: https://doaj.org/article/4e0fa0757b774e4ca29813340f26d393

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Akademický článek

Markers for human haematopoietic stem cells: The disconnect between an identification marker and its function

Autor: Beatrice Rix, Andres Hernandez Maduro, Katherine S. Bridge, William Grey

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

The haematopoietic system is a classical stem cell hierarchy that maintains all the blood cells in the body. Haematopoietic stem cells (HSCs) are rare, highly potent cells that reside at the apex of this hierarchy and are historically some of the mos

Externí odkaz: https://doaj.org/article/81f41930c2d348d8afec038a07043cb3

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Kniha

The living brain / W. G. Walter.

Autor: Walter, William Grey, 1910-

Akademický článek

WT1 β'ing catenin into shape: a new interaction driving epigenetic plasticity in acute myeloid leukemia?

Autor: William Grey

Publikováno v: Haematologica, Vol 108, Iss 1 (2022)

Externí odkaz: https://doaj.org/article/71c944d803894287841b81f420137b79

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Akademický článek

Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis

Autor: Cristina Morales Torres, Mary Y. Wu, Sebastijan Hobor, Elanor N. Wainwright, Matthew J. Martin, Harshil Patel, William Grey, Eva Grönroos, Steven Howell, Joana Carvalho, Ambrosius P. Snijders, Michael Bustin, Dominique Bonnet, Paul D. Smith, Charles Swanton, Michael Howell, Paola Scaffidi

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restori

Externí odkaz: https://doaj.org/article/f8d840aac93c41c6937b76b29e6d3cbc

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Akademický článek

The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia

Autor: Alessandro Di Tullio, Kevin Rouault-Pierre, Ander Abarrategi, Syed Mian, William Grey, John Gribben, Aengus Stewart, Elizabeth Blackwood, Dominique Bonnet

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Overriding cytarabine resistance in AML remains an unmet medical need. Here, the authors show that the CHK1 inhibitor GDC-0575 in combination with cytarabine and G-CSF has a significant anti-leukemic effect without toxicity to normal marrow stem and

Externí odkaz: https://doaj.org/article/77ff00f53b1049f3aa2acb231a637d78

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