Zobrazeno 1 - 9
of 9
pro vyhledávání: '"William, Greenlee"'
Autor:
Mieko Matsuyama, Joseph T. Ortega, Yuri Fedorov, Jonah Scott-McKean, Jeannie Muller-Greven, Matthias Buck, Drew Adams, Beata Jastrzebska, William Greenlee, Shigemi Matsuyama
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107916- (2023)
Summary: We identified cytoprotective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barr
Externí odkaz:
https://doaj.org/article/1b08a37ed62546f2b414148b8dfcf5c3
Autor:
Mieko Matsuyama, Joseph T. Ortega, Yuri Fedorov, Jonah Scott-McKean, Jeannie Muller-Greven, Matthias Buck, Drew Adams, Beata Jastrzebska, William Greenlee, Shigemi Matsuyama
We identified cyto-protective small molecules (CSMs) by a cell-based high-throughput screening of Bax inhibitors. Through a medicinal chemistry program, M109S was developed, which is orally bioactive and penetrates the blood-brain/retina barriers. M1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::535cbbf76862886797af5f73002fca78
https://doi.org/10.1101/2022.10.12.511987
https://doi.org/10.1101/2022.10.12.511987
Autor:
Julius J. Matasi, Stephanie Brumfield, Deen Tulshian, Michael Czarnecki, William Greenlee, Charles G. Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Youngliang Sun, Rosalia Bertorelli, William Geiss, Van-Duc Le, Gregory S. Martin, Samuel A. Vellekoop, James Haber, Melissa L. Allard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3805-3808
Structure-activity relationship (SAR) efforts around our initial lead compound 1 led to the identification of potent P2X(7) receptor antagonists with improved pharmacokinetic profiles. These compounds were potent and selective at the P2X(7) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eb025e3d5e21bb6c67880ae2ad4913
https://doi.org/10.1016/j.bmcl.2011.04.034
https://doi.org/10.1016/j.bmcl.2011.04.034
Autor:
Duane, DeMong, Xing, Dai, Joyce, Hwa, Michael, Miller, Sue-Ing, Lin, Ling, Kang, Andrew, Stamford, William, Greenlee, Wensheng, Yu, Michael, Wong, Brian, Lavey, Joseph, Kozlowski, Guowei, Zhou, De-Yi, Yang, Bhuneshwari, Patel, Aileen, Soriano, Ying, Zhai, Christopher, Sondey, Hongtao, Zhang, Jean, Lachowicz, Diane, Grotz, Kathleen, Cox, Richard, Morrison, Teresa, Andreani, Yang, Cao, Mark, Liang, Tao, Meng, Paul, McNamara, Jesse, Wong, Prudence, Bradley, Kung-I, Feng, Jitendra, Belani, Ping, Chen, Peng, Dai, Jolicia, Gauuan, Peishan, Lin, He, Zhao
Publikováno v:
Journal of medicinal chemistry. 57(6)
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7428e9b03dd835df4d86fffa2b642e9e
https://pubmed.ncbi.nlm.nih.gov/24527772
https://pubmed.ncbi.nlm.nih.gov/24527772
Autor:
Stephanie Brumfield, Julius J. Matasi, Deen Tulshian, Michael Czarniecki, William Greenlee, Charles Garlisi, Hongchen Qiu, Kristine Devito, Shu-Cheng Chen, Yongliang Sun, Rosalia Bertorelli, Justin Ansell, William Geiss, Van-Duc Le, Gregory S. Martin, Samuel A. Vellekoop, James Haber, Melissa L. Allard
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(24)
Novel P2X(7) antagonists were developed using a purine scaffold. These compounds were potent and selective at the P2X(7) receptor in human and rodent as well as efficacious in rodent pain models. Compound 15a was identified to have oral potency in se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ebe62239fe0e5063260d2fbbb27b57
https://pubmed.ncbi.nlm.nih.gov/22078214
https://pubmed.ncbi.nlm.nih.gov/22078214
Autor:
William Greenlee
Publikováno v:
Future Medicinal Chemistry. 5:375-376
William Greenlee, the founder and president of MedChem Discovery Consulting LLC, has over three decades of research experience in industry at Merck Research Laboratories and the Schering–Plough Research Institute. He has contributed to the advancem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0c8148f4e8025bf3984be073c42ba59
https://doi.org/10.4155/fmc.12.212
https://doi.org/10.4155/fmc.12.212
Autor:
Mariappan V. Chelliah, Samuel Chackalamannil, Yan Xia, Keith Eagen, Martin C. Clasby, Xiaobang Gao, William Greenlee, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Yunsheng Hsieh, Matthew Bryant, Jairam Palamanda, Tze-Ming Chan, David Hesk, Madhu Chintala
Publikováno v:
Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 21, p5147-5160, 14p
Autor:
Martin C. Clasby, Samuel Chackalamannil, Michael Czarniecki, Dario Doller, Keith Eagen, William Greenlee, Grace Kao, Yan Lin, Hsingan Tsai, Yan Xia, Ho-Sam Ahn, Jacqueline Agans-Fantuzzi, George Boykow, Madhu Chintala, Carolyn Foster, April Smith-Torhan, Kevin Alton, Matthew Bryant, Yunsheng Hsieh, Janice Lau
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 1, p129-138, 10p