Zobrazeno 1 - 10
of 19
pro vyhledávání: '"William, De Nardo"'
Autor:
Hamzeh Karimkhanloo, Stacey N. Keenan, Jacqueline Bayliss, William De Nardo, Paula M. Miotto, Camille J. Devereux, Shuai Nie, Nicholas A. Williamson, Andrew Ryan, Matthew J. Watt, Magdalene K. Montgomery
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Non-alcoholic steatohepatitis (NASH), characterized as the joint presence of steatosis, hepatocellular ballooning and lobular inflammation, and liver fibrosis are strong contributors to liver-related and overall mortality. Despite the high g
Externí odkaz:
https://doaj.org/article/0f81f952cf38469ca8daa7ce5886971f
Autor:
Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie, William De Nardo, Stacey N. Keenan, Paula M. Miotto, Hamzeh Karimkhanloo, Cheng Huang, Ralf B. Schittenhelm, Anthony S. Don, Andrew Ryan, Nicholas A. Williamson, Geraldine J. Ooi, Wendy A. Brown, Paul R. Burton, Benjamin L. Parker, Matthew J. Watt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, but the connecting pathophysiological mechanisms are incompletely understood. Here the authors identify arylsulfatase A as a NASH-induced hepatokine that inhibits hepatic ly
Externí odkaz:
https://doaj.org/article/0e3d36630f204b8aa3e526d0e0913eb1
Autor:
William De Nardo, Paula M. Miotto, Jacqueline Bayliss, Shuai Nie, Stacey N. Keenan, Magdalene K. Montgomery, Matthew J. Watt
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101491- (2022)
Objective: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which is partly mediated by altered secretion of liver proteins known as hepatokines. Regular physical activity can resolve N
Externí odkaz:
https://doaj.org/article/703f3df833344ba2a9037ed17054464f
Autor:
Jacqueline Bayliss, Geraldine J. Ooi, William De Nardo, Yazmin Johari Halim Shah, Magdalene K. Montgomery, Catriona McLean, William Kemp, Stuart K. Roberts, Wendy A. Brown, Paul R. Burton, Matthew J. Watt
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Ectodysplasin A (EDA) was recently identified as a liver-secreted protein that is increased in the liver and plasma of obese mice and causes skeletal muscle insulin resistance. We assessed if liver and plasma EDA is associated with worsening non-alco
Externí odkaz:
https://doaj.org/article/25a873eb0dba42f9920526140db6b0cf
Autor:
Stacey N. Keenan, William De Nardo, Jieqiong Lou, Ralf B. Schittenhelm, Magdalene K. Montgomery, James G. Granneman, Elizabeth Hinde, Matthew J. Watt
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100016- (2021)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). We sought to identify
Externí odkaz:
https://doaj.org/article/fa5a9be0f3824de49839e18d04e01713
Autor:
Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie, William de Nardo, Stacey N. Keenan, Marziyeh Anari, Amanuiel Z. Taddese, Nicholas A. Williamson, Geraldine J. Ooi, Wendy A. Brown, Paul R. Burton, Paul Gregorevic, Craig A. Goodman, Kevin I. Watt, Matthew J. Watt
Publikováno v:
Diabetes. 72:715-727
Non-alcoholic fatty liver disease (NAFLD) and impaired glycaemic control are closely linked, however, the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. The high secretory capacity of the liver and impai
Autor:
Gio Fidelito, David P. De Souza, Birunthi Niranjan, William De Nardo, Shivakumar Keerthikumar, Kristin Brown, Renea A. Taylor, Matthew J. Watt
Publikováno v:
Molecular Cancer Research. 21:359-373
Cancer cells undergo metabolic reprogramming to meet increased bioenergetic demands. Studies in cells and mice have highlighted the importance of oxidative metabolism and lipogenesis in prostate cancer; however, the metabolic landscape of human prost
Autor:
Matthew J. Watt, Renea A. Taylor, Kristin Brown, Shivakumar Keerthikumar, William De Nardo, Birunthi Niranjan, David P. De Souza, Gio Fidelito
Supplementary Figure 1. Metabolic profiles of prostate cancer PDX across different pathology. Supplementary Figure 2. Percent labeling of glycolysis end products and TCA cycle intermediates following 4 hours ex vivo labelling of 13C substrates. Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081290a939ea1c60aa60d640bf465f0a
https://doi.org/10.1158/1541-7786.22495225.v1
https://doi.org/10.1158/1541-7786.22495225.v1
Autor:
Matthew J. Watt, Renea A. Taylor, Kristin Brown, Shivakumar Keerthikumar, William De Nardo, Birunthi Niranjan, David P. De Souza, Gio Fidelito
Cancer cells undergo metabolic reprogramming to meet increased bioenergetic demands. Studies in cells and mice have highlighted the importance of oxidative metabolism and lipogenesis in prostate cancer; however, the metabolic landscape of human prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e23f2b6e8a3a67f37ab49d866a17437
https://doi.org/10.1158/1541-7786.c.6534778.v1
https://doi.org/10.1158/1541-7786.c.6534778.v1
Autor:
Matthew J. Watt, Renea A. Taylor, Kristin Brown, Shivakumar Keerthikumar, William De Nardo, Birunthi Niranjan, David P. De Souza, Gio Fidelito
Supplementary Table 1: Correlation coefficients and P values of metabolic rates and ssGSEA score. Supplementary Table 2: Correlation coefficients and P values of metabolic rates and genetic mutations. Supplementary Table 3: Correlation coefficients a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c04409cda0ddae376ca235e5f2fe24c
https://doi.org/10.1158/1541-7786.22495219
https://doi.org/10.1158/1541-7786.22495219