Twin Concordance and Sibling Recurrence Rates in Multiple Sclerosis

Autor: Willer, C. J., Dyment, D. A., Risch, N. J., Sadovnick, A. D., Ebers, G. C.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2003 Oct . 100(22), 12877-12882.

Externí odkaz: https://www.jstor.org/stable/3148054

A first update on mapping the human genetic architecture of COVID-19

Autor: COVID-19 Host Genetics Initiative, Pathak, GA, Karjalainen, J, Stevens, C, Neale, BM, Daly, M, Ganna, A, Andrews, SJ, Kanai, M, Cordioli, M, Polimanti, R, Harerimana, N, Pirinen, M, Liao, RG, Chwialkowska, K, Trankiem, A, Balaconis, MK, Nguyen, H, Solomonson, M, Veerapen, K, Wolford, B, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Niemi, MEK, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Azarzar, S, Gofflot, S, Claassen, S, Malaise, O, Huynen, P, Meuris, C, Thys, M, Jacques, J, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Frenckell, CV, Belhaj, Y, Lambermont, B, Nakanishi, T, Morrison, DR, Mooser, V, Richards, JB, Butler-Laporte, G, Forgetta, V, Li, R, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, DE, Lathrop, GM, Adra, D, Hayward, C, Glessner, JT, Shaw, DM, Campbell, A, Morris, M, Hakonarson, H, Porteous, DJ, Below, J, Richmond, A, Chang, X, Polikowski, H, Lauren, PE, Chen, H-H, Wanying, Z, Fawns-Ritchie, C, North, K, McCormick, JB, Glessner, JR, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Timmers, PRHJ, Wilson, JF, Tenesa, A, Kerr, SM, D’Mellow, K, Shahin, D, El-Sherbiny, YM, von Hohenstaufen, KA, Sobh, A, Eltoukhy, MM, Nkambul, L, Elhadidy, TA, Abd Elghafar, MS, El-Jawhari, JJ, Mohamed, AAS, Elnagdy, MH, Samir, A, Abdel-Aziz, M, Khafaga, WT, El-Lawaty, WM, Torky, MS, El-shanshory, MR, Yassen, AM, Hegazy, MAF, Okasha, K, Eid, MA, Moahmed, HS, Medina-Gomez, C, Ikram, MA, Uitterlinden, AG, Mägi, R, Milani, L, Metspalu, A, Laisk, T, Läll, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Batini, C, Tobin, MD, Venn, LD, Lee, PH, Shrine, N, Williams, AT, Guyatt, AL, John, C, Packer, RJ, Ali, A, Free, RC, Wang, X, Wain, LV, Hollox, EJ, Bee, CE, Adams, EL, Palotie, A, Ripatti, S, Ruotsalainen, S, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Kaunisto, M, Rivolta, C, Bochud, P-Y, Bibert, S, Boillat, N, Nussle, SG, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Friolet, R, Vollenweider, P, Pagani, JL, Oddo, M, zu Bentrup, FM, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, RM, Lannepoudenx, Y, Portopena, L, Bochud, PY, Desgranges, F, Filippidis, P, Guéry, B, Haefliger, D, Kampouri, EE, Manuel, O, Munting, A, 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Publikováno v: Nature, 608(7921), E1-E10. Nature Publishing Group
Nature, 608. Nature Publishing Group
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COVID-19 Host Genetics Initiative, Hottenga, J J, Bartels, M, de Geus, E J C & Nivard, M 2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7
2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7

Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827cbe7f6ea8d3fe660425d3d9cc06f9
https://doi.org/10.1038/s41586-022-04826-7

Whole genome sequencing reveals host factors underlying critical Covid-19

Autor: Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., Zechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Mcauley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J., Baillie, J. K., Begg, C., Ling, L., Pereira, A. C., Aravindan, L., Armstrong, R., Biggs, H., Boz, C., Brown, A., Clark, R., Coutts, A., Coyle, J., Cullum, L., Das, S., Day, N., Donnelly, L., Duncan, E., Finernan, P., Fourman, M. H., Furlong, A., Furniss, J., Gallagher, B., Gilchrist, T., Golightly, A., Hafezi, K., Hamilton, D., Hendry, R., Law, D., Law, R., Law, S., Lidstone-Scott, R., Macgillivray, L., Maclean, A., Mal, H., Mccafferty, S., Mcmaster, E., Meikle, J., Moore, S. C., Murphy, S., Hellen, M., Zheng, C., Chen, J., Paterson, T., Schon, K., Stenhouse, A., Das, M., Swets, M., Szoor-McElhinney, H., Taneski, F., Turtle, L., Wackett, T., Ward, M., Weaver, J., Wrobel, N., Arbane, G., Bociek, A., Campos, S., Grau, N., Jones, T. 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J., Neale, B. M., Ganna, A.

Publikováno v: Kousathanas, A, Pairo-Castineira, E, Rawlik, K, Stuckey, A, Odhams, C A, Walker, S, Russell, C D, Malinauskas, T, Wu, Y, Millar, J, Shen, X, Elliott, K S, Griffiths, F, Oosthuyzen, W, Morrice, K, Keating, S, Wang, B, Rhodes, D, Klaric, L, Zechner, M, Parkinson, N, Siddiq, A, Goddard, P, Donovan, S, Maslove, D, Nichol, A, Semple, M G, Zainy, T, Maleady-Crowe, F, Todd, L, Salehi, S, Knight, J, Elgar, G, Chan, G, Arumugam, P, Patch, C, Rendon, A, Bentley, D, Kingsley, C, Kosmicki, J A, Horowitz, J E, Baras, A, Abecasis, G R, Ferreira, M A R, Justice, A, Mirshahi, T, Oetjens, M, Rader, D J, Ritchie, M D, Verma, A, Fowler, T A, Shankar-Hari, M, Summers, C, Hinds, C, Horby, P, Ling, L, McAuley, D, Montgomery, H, Openshaw, P J M, Elliott, P, Walsh, T, Tenesa, A, Fawkes, A, Murphy, L, Rowan, K, Ponting, C P, Vitart, V, Wilson, J F, Yang, J, Bretherick, A D, Scott, R H, Hendry, S C, Moutsianas, L, Law, A & Caulfield, M J & Baillie, J K 2022, ' Whole genome sequencing reveals host factors underlying critical Covid-19 ', Nature, vol. 607, pp. 97-103 . https://doi.org/10.1038/s41586-022-04576-6
Nature, 607(7917), 97-103. Nature Publishing Group
GenOMICC Investigators, 23andMe & Covid-19 Human Genetics Initiative 2022, ' Whole genome sequencing reveals host factors underlying critical Covid-19 ', Nature . https://doi.org/10.1038/s41586-022-04576-6
Kousathanas, A, Nivard, M, de Geus, E, Bartels, M, Jan Hottenga, J, Baillie, J K, GenOMICC co-investigators, COVID-19 Human Genetics Initiative & 23andMe investigators 2022, ' Whole-genome sequencing reveals host factors underlying critical COVID-19 ', Nature, vol. 607, no. 7917, pp. 97-103 . https://doi.org/10.1038/s41586-022-04576-6
GenOMICC Investigators 2022, ' Whole-genome sequencing reveals host factors underlying critical COVID-19 ', Nature, vol. 607, no. 7917, pp. 97-103 . https://doi.org/10.1038/s41586-022-04576-6
NATURE

34 páginas, 3 figuras, 1 tabla.
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215a487f3f7be450d54070fbc35ececa
https://hdl.handle.net/11577/3465409

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Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

Autor: Shrine N; Department of Population Health Sciences, University of Leicester, Leicester, UK. nick.shrine@leicester.ac.uk., Izquierdo AG; Department of Population Health Sciences, University of Leicester, Leicester, UK., Chen J; Department of Population Health Sciences, University of Leicester, Leicester, UK., Packer R; Department of Population Health Sciences, University of Leicester, Leicester, UK., Hall RJ; Division of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK., Guyatt AL; Department of Population Health Sciences, University of Leicester, Leicester, UK., Batini C; Department of Population Health Sciences, University of Leicester, Leicester, UK.; Leicester National Institute for Health and Care Research, Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Thompson RJ; Division of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK., Pavuluri C; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Malik V; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Hobbs BD; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Moll M; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kim W; Channing Division of Network Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Tal-Singer R; COPD Foundation, Washington DC, USA., Bakke P; Department of Clinical Science, Unversity of Bergen, Bergen, Norway., Fawcett KA; Department of Population Health Sciences, University of Leicester, Leicester, UK., John C; Department of Population Health Sciences, University of Leicester, Leicester, UK.; Leicester National Institute for Health and Care Research, Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Coley K; Department of Population Health Sciences, University of Leicester, Leicester, UK., Piga NN; Department of Population Health Sciences, University of Leicester, Leicester, UK., Pozarickij A; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, University of Oxford, Oxford, UK., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., Wijnant SRA; Department of Respiratory Diseases, Ghent Universital Hospital, Ghent, Belgium.; Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.; Department of Epidemiology, Eramus Medical Center, Rotterdam, The Netherlands., Lahousse L; Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.; Department of Epidemiology, Eramus Medical Center, Rotterdam, The Netherlands., Brusselle G; Department of Respiratory Diseases, Ghent Universital Hospital, Ghent, Belgium.; Department of Epidemiology, Eramus Medical Center, Rotterdam, The Netherlands., Uitterlinden AG; Department of Internal Medicine, Eramus Medical Center, Rotterdam, The Netherlands., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Oelsner EC; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Barr RG; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Kerr SM; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Wielscher M; MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Imboden M; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; Department of Public Health, University of Basel, Basel, Switzerland., Jeong A; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; Department of Public Health, University of Basel, Basel, Switzerland., Bartz TM; Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA., Gharib SA; Computational Medicine Core, Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA., Flexeder C; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Karrasch S; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig Maximilian University, Munich, Germany., Stubbe B; Department of Internal Medicine B-Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University Medicine Greifswald, Greifswald, Germany., Hu X; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Ortega VE; Division of Respiratory Medicine, Department of Internal Medicine, Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA., Meyers DA; Department of Medicine, University of Arizona, Tucson, AZ, USA., Bleecker ER; Department of Medicine, University of Arizona, Tucson, AZ, USA., Gabriel SB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gupta N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Smith AV; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Zhao JH; Department of Public and Primary Care, Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Hansen AF; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway., Langhammer A; HUNT Research Centre, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Levanger, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Willer C; Division of Cardiology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Bhatta L; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Trondheim, Norway., Porteous D; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Lee J; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Daviglus ML; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA., Yu B; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Lim E; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Xu H; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA., O'Connor GT; Pulmonary Center, School of Medicine, Boston University, Boston, MA, USA., Thareja G; Bioinformatics Core, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar., Albagha OME; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.; Center for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Suhre K; Bioinformatics Core, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.; Department of Biophysics and Physiology, Weill Cornell Medicine, New York, NY, USA., Granell R; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Faquih TO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Hiemstra PS; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands., Slats AM; Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands., Mullin BH; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia., Hui J; Busselton Population Medical Research Institute, QEII Medical Centre, Nedlands, Western Australia, Australia.; School of Population and Global Health, University of Western Australia, Crawley, Western Australia, Australia.; PathWest Laboratory Medicine of WA, Nedlands, Western Australia, Australia., James A; Busselton Population Medical Research Institute, QEII Medical Centre, Nedlands, Western Australia, Australia., Beilby J; School of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia.; Busselton Population Medical Research Institute, QEII Medical Centre, Nedlands, Western Australia, Australia., Patasova K; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London, UK.; Division of Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Hysi P; Department of Twin Research and Genetic Epidemiology, King's College London School of Medicine, London, UK.; UCL Institute of Ophthalmology, University College London, London, UK., Koskela JT; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Wyss AB; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA., Jin J; Westat, Durham, NC, USA., Sikdar S; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.; Department of Mathematics and Statistics, Old Dominion University, Norfolk, VA, USA., Lee M; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA., May-Wilson S; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Pirastu N; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Kentistou KA; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Joshi PK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Timmers PRHJ; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Williams AT; Department of Population Health Sciences, University of Leicester, Leicester, UK., Free RC; Leicester National Institute for Health and Care Research, Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK., Wang X; Leicester National Institute for Health and Care Research, Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; Department of Respiratory Sciences, University of Leicester, Leicester, UK., Morrison JL; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gilliland FD; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Chen Z; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.; Hunter Medical Research Institute, Newcastle, New South Wales, Australia., Foong RE; Wal-yan Respiratory Research Centre, Telethon Kids Institute, Perth, Western Australia, Australia.; School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia., Harris SE; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Taylor A; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Redmond P; Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Mahajan A; 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Publikováno v: Nature genetics [Nat Genet] 2023 Oct; Vol. 55 (10), pp. 1778-1779.