Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system.

Autor: Qi L; Department of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, 94720, USA., Groeger M; Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, 94143, USA.; Eli and Edythe Broad Center for Regeneration Medicine, University of California San Francisco, San Francisco, CA, 94143, USA., Sharma A; Eli and Edythe Broad Center for Regeneration Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, 94143, USA., Goswami I; Department of Bioengineering, College of Engineering, University of California Berkeley, Berkeley, CA, 94720, USA., Chen E; Department of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, 94720, USA., Zhong F; Department of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, 94720, USA., Ram A; Eli and Edythe Broad Center for Regeneration Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, 94143, USA., Healy K; Department of Bioengineering, College of Engineering, University of California Berkeley, Berkeley, CA, 94720, USA.; Department of Materials Science and Engineering, College of Engineering, University of California Berkeley, Berkeley, CA, 94720, USA., Hsiao EC; Eli and Edythe Broad Center for Regeneration Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, 94143, USA., Willenbring H; Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, 94143, USA. holger.willenbring@ucsf.edu.; Eli and Edythe Broad Center for Regeneration Medicine, University of California San Francisco, San Francisco, CA, 94143, USA. holger.willenbring@ucsf.edu.; Liver Center, University of California San Francisco, San Francisco, CA, 94143, USA. holger.willenbring@ucsf.edu., Stahl A; Department of Nutritional Science and Toxicology, College of Natural Resources, University of California Berkeley, Berkeley, CA, 94720, USA. astahl@berkeley.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 12; Vol. 15 (1), pp. 7991. Date of Electronic Publication: 2024 Sep 12.

Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.

Autor: Groeger M; Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, 94143, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, 94143, USA., Matsuo K; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, 94143, USA., Heidary Arash E; Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, 94143, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, 94143, USA., Pereira A; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, 94143, USA., Le Guillou D; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Liver Center, University of California San Francisco, San Francisco, CA, 94143, USA., Pino C; Liver Center, University of California San Francisco, San Francisco, CA, 94143, USA.; Genomics CoLab, University of California San Francisco, San Francisco, CA, 94143, USA., Telles-Silva KA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, 94143, USA.; Human Genome and Stem Cell Research Center, University of Sao Paulo, 05508-090, Sao Paulo, Brazil., Maher JJ; Division of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Liver Center, University of California San Francisco, San Francisco, CA, 94143, USA., Hsiao EC; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, 94143, USA.; Division of Endocrinology and Metabolism, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, 94143, USA., Willenbring H; Division of Transplant Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, 94143, USA. holger.willenbring@ucsf.edu.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, 94143, USA. holger.willenbring@ucsf.edu.; Liver Center, University of California San Francisco, San Francisco, CA, 94143, USA. holger.willenbring@ucsf.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jul 03; Vol. 14 (1), pp. 3902. Date of Electronic Publication: 2023 Jul 03.

Aquaporin 9 induction in human iPSC-derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency.

Autor: Laemmle A; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA.; Department of Pediatrics, University Children's Hospital, Bern, Switzerland.; University Institute of Clinical Chemistry, University of Bern, Bern, Switzerland., Poms M; Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich, Switzerland., Hsu B; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA., Borsuk M; University Institute of Clinical Chemistry, University of Bern, Bern, Switzerland., Rüfenacht V; Division of Metabolism and Children`s Research Center, University Children's Hospital, Zurich, Switzerland., Robinson J; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA.; Center for Reproductive Sciences, University of California San Francisco, San Francisco, California, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, California, USA.; Department of Pediatrics, Medical Genetics, University of California San Francisco, San Francisco, California, USA., Sadowski MC; Institute of Pathology, University of Bern, Bern, Switzerland., Nuoffer JM; Department of Pediatrics, University Children's Hospital, Bern, Switzerland.; University Institute of Clinical Chemistry, University of Bern, Bern, Switzerland., Häberle J; Division of Metabolism and Children`s Research Center, University Children's Hospital, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Willenbring H; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA.; Department of Surgery, Division of Transplant Surgery, University of California San Francisco, San Francisco, California, USA.; Liver Center, University of California San Francisco, San Francisco, California, USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2022 Sep; Vol. 76 (3), pp. 646-659. Date of Electronic Publication: 2021 Dec 18.

Telomerase activity distinguishes between neuroblastomas with poor prognosis

Autor: Poremba, C., Willenbring, H., Hero, B., Christiansen, H., Schäfer, K.-L., Brinkschmidt, C., Jürgens, H., Böcker, W., Dockhorn-Dworniczak, B. ^*

Publikováno v: In Annals of Oncology June 1999 10(6):715-721

Integrated Isogenic Human Induced Pluripotent Stem Cell-Based Liver and Heart Microphysiological Systems Predict Unsafe Drug-Drug Interaction.

Autor: Lee-Montiel FT; Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States., Laemmle A; Department of Surgery, Division of Transplant Surgery, Liver Center and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, United States.; Institute of Clinical Chemistry and Department of Pediatrics, Inselspital, University Hospital Bern, Bern, Switzerland., Charwat V; Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States., Dumont L; Department of Surgery, Division of Transplant Surgery, Liver Center and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, United States., Lee CS; Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States., Huebsch N; Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States., Okochi H; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, CA, United States., Hancock MJ; Veryst Engineering, LLC, Needham, MA, United States., Siemons B; Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States., Boggess SC; Department of Chemistry, University of California Berkeley, Berkeley, CA, United States., Goswami I; Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States., Miller EW; Departments of Chemistry and Molecular & Cell Biology, and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, United States., Willenbring H; Department of Surgery, Division of Transplant Surgery, Liver Center and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, United States., Healy KE; Departments of Bioengineering, and Materials Science & Engineering, University of California Berkeley, Berkeley, CA, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2021 May 07; Vol. 12, pp. 667010. Date of Electronic Publication: 2021 May 07 (Print Publication: 2021).