Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

Autor: Peters, Marjolein, Broer, Linda, Willemen, HLDM, Eiriksdottir, G, Hocking, LJ, Holliday, KL, Horan, MA, Meulenbelt, I, Neogi, T, Popham, M, Schmidt, CO, Soni, A, Valdes, AM, Amin, Najaf, Dennison, EM, Eijkelkamp, N, Harris, TB, Hart, DJ, Hofman, Bert, Huygen, Frank, Jameson, KA, Jones, GT, Launer, LJ (Lenore), Kerkhof, HJM, Kruijf, Marjolein, McBeth, J, Kloppenburg, M, Ollier, WE, Oostra, Ben, Payton, A, Rivadeneira, Fernando, Smith, BH, Smith, AV, Stolk, Lisette, Teumer, A, Thomson, W, Uitterlinden, André, Wang, K, Wingerden, Sophie, Arden, NK, Cooper, C, Felson, D, Gudnason, V, Macfarlane, GJ, Pendleton, N, Slagboom, PE (Eline), Spector, TD, Volzke, H, Kavelaars, A, Duijn, Cornelia, Williams, FMK, van Meurs, Joyce

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, 72(3), 427-436
Annals of the Rheumatic Diseases, 72(3), 427-436. BMJ Publishing Group

BACKGROUND AND OBJECTIVES: Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first large-scale genome-wide association study (GWAS) meta-analysis, we aime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f4380922c5dbc0d575258f7fdd13fda1
https://pubmed.ncbi.nlm.nih.gov/22956598

Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain.

Autor: Willemen HLDM; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands., Santos Ribeiro PS; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands., Broeks M; Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands., Meijer N; Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands., Versteeg S; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands., Tiggeler A; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands., de Boer TP; Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 Utrecht, the Netherlands., Małecki JM; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway; CRES-O - Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, Oslo, Norway., Falnes PØ; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway; CRES-O - Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, Oslo, Norway., Jans J; Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands., Eijkelkamp N; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, 3508 Utrecht, the Netherlands. Electronic address: n.eijkelkamp@umcutrecht.nl.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Nov 21; Vol. 4 (11), pp. 101265. Date of Electronic Publication: 2023 Nov 08.

Mitochondria and sensory processing in inflammatory and neuropathic pain.

Autor: Silva Santos Ribeiro P; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Willemen HLDM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Eijkelkamp N; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Publikováno v: Frontiers in pain research (Lausanne, Switzerland) [Front Pain Res (Lausanne)] 2022 Oct 17; Vol. 3, pp. 1013577. Date of Electronic Publication: 2022 Oct 17 (Print Publication: 2022).

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes.

Autor: Davydova E; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway., Shimazu T; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan., Schuhmacher MK; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany., Jakobsson ME; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research (NNF-CPR), University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark.; Department of Immunotechnology, Lund University, Medicon Village, 22100, Lund, Sweden., Willemen HLDM; Center for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht University, 3584, Utrecht, EA, The Netherlands., Liu T; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Moen A; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway., Ho AYY; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway., Małecki J; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway., Schroer L; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway., Pinto R; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway.; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Suzuki T; Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Grønsberg IA; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway., Sohtome Y; Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Akakabe M; Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan., Weirich S; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany., Kikuchi M; Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Olsen JV; Proteomics Program, Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Protein Research (NNF-CPR), University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark., Dohmae N; Biomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Umehara T; Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Sodeoka M; Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Siino V; Department of Immunotechnology, Lund University, Medicon Village, 22100, Lund, Sweden., McDonough MA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Eijkelkamp N; Center for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht University, 3584, Utrecht, EA, The Netherlands., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Jeltsch A; Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany. albert.jeltsch@ibtb.uni-stuttgart.de., Shinkai Y; Cellular Memory Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan. yshinkai@riken.jp., Falnes PØ; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316, Oslo, Norway. pal.falnes@ibv.uio.no.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 09; Vol. 12 (1), pp. 891. Date of Electronic Publication: 2021 Feb 09.

Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.

Autor: Małecki JM; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway j.m.malecki@ibv.uio.no., Willemen HLDM; Laboratory of Translational Immunology (LTI), University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands., Pinto R; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway., Ho AYY; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway., Moen A; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway., Eijkelkamp N; Laboratory of Translational Immunology (LTI), University Medical Center Utrecht, Utrecht University, 3584 EA Utrecht, The Netherlands., Falnes PØ; Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway pal.falnes@ibv.uio.no.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Aug 02; Vol. 294 (31), pp. 11654-11664. Date of Electronic Publication: 2019 Jun 18.