Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Willem-Jan Pannekoek"'
Publikováno v:
F1000Research, Vol 8 (2019)
Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells. Mor
Externí odkaz:
https://doaj.org/article/d73abc2064584a36b5ade948bc890b63
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57903 (2013)
Rap1 and Rap2 are closely related proteins of the Ras family of small G-proteins. Rap1 is well known to regulate cell-cell adhesion. Here, we have analysed the effect of Rap-mediated signalling on endothelial permeability using electrical impedance m
Externí odkaz:
https://doaj.org/article/b4e25ce51f434fc6ba78364c25f462c9
Autor:
M. J. Vliem, M. Bosch-Padros, Xavier Trepat, Nicolas Borghi, H. Canever, Martijn Gloerich, Lisa Donker, Willem-Jan Pannekoek, M. Gomez-Gonzalez
Epithelial cell divisions must be tightly coordinated with cell loss to preserve epithelial integrity. However, it is not well understood how the rate of epithelial cell division adapts to changes in cell number, for instance during homeostatic turno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc99796aa2fcf6d3b86c11d52db1c553
https://doi.org/10.1101/2021.11.29.470352
https://doi.org/10.1101/2021.11.29.470352
Autor:
Joleen S. Cheah, Chi-Fu Yen, Willem-Jan Pannekoek, Martijn Gloerich, Andrew Vae Priest, Ramesh Koirala, Sanjeevi Sivasankar, Soichiro Yamada
Publikováno v:
Proc Natl Acad Sci U S A
Cadherin cell-cell adhesion proteins play key roles in tissue morphogenesis and wound healing. Cadherin ectodomains bind in two conformations, X-dimers and strand-swap dimers, with different adhesive properties. However, the mechanisms by which cells
Publikováno v:
Small GTPases
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Epac1 and Rap1 mediate cAMP-induced tightening of endothelial junctions. We have previously found that one of the mechanisms is the inhibition of Rho-mediated tension in radial stress fibers by recruiting the RhoGAP ArhGAP29 in a complex containing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fd53c6a097e51ac00eb566704c19b0
Publikováno v:
Developmental Cell. 53:263-271.e6
Summary Symmetry breaking is an essential step in cell differentiation and early embryonic development. However, the molecular cues that trigger symmetry breaking remain largely unknown. Here, we show that mitochondrial H2O2 acts as a symmetry-breaki
Publikováno v:
Molecular and Cellular Biology, 35(14), 2495. American Society for Microbiology
The small GTPase Rap1 controls the actin cytoskeleton by regulating Rho GTPase signaling. We recently established that the Rap1 effectors Radil and Rasip1, together with the Rho GTPase activating protein ArhGAP29, mediate Rap1-induced inhibition of R
Publikováno v:
F1000Research
Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells. Mor
Autor:
Sarah H. Ross, Anneke Post, Willem-Jan Pannekoek, Patricia M. Brouwer, Johannes L. Bos, Ingrid Verlaan
Publikováno v:
Proceedings of the National Academy of Sciences. 110:11427-11432
Rap1 is a small GTPase regulating cell–cell adhesion, cell–matrix adhesion, and actin rearrangements, all processes dynamically coordinated during cell spreading and endothelial barrier function. Here, we identify the adaptor protein ras-interact
Autor:
Emma Spanjaard, Jelena R. Linnemann, Johan de Rooij, Patricia M. Brouwer, Jantine J.G. van Dijk, On Ying A. Chan, Fried J. T. Zwartkruis, Holger Rehmann, Johannes L. Bos, Stephan Huveneers, Willem-Jan Pannekoek, Anne Jan van der Meer
Publikováno v:
Cellular Signalling, 23(12), 2056-2064. Elsevier B.V.
Epac1 and its effector Rap1 are important mediators of cAMP induced tightening of endothelial junctions and consequential increased barrier function. We have investigated the involvement of Rap1 signalling in basal, unstimulated, barrier function of