Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Autor: Marion Pardons, Basiel Cole, Laurens Lambrechts, Willem van Snippenberg, Sofie Rutsaert, Ytse Noppe, Nele De Langhe, Annemieke Dhondt, Jerel Vega, Filmon Eyassu, Erik Nijs, Ellen Van Gulck, Daniel Boden, Linos Vandekerckhove

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract The development of latency reversing agents that potently reactivate HIV without inducing global T cell activation would benefit the field of HIV reservoir research and could pave the way to a functional cure. Here, we explore the reactivati

Externí odkaz: https://doaj.org/article/3f371f7550f64091855de84f1077f564

Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption

Autor: Tinus Schynkel, Willem van Snippenberg, Clarissa Van Hecke, Linos Vandekerckhove, Wim Trypsteen

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 2, p 1031 (2023)

Lately, the interest in long non-coding RNAs (lncRNAs) as potential drug targets and predictive markers in the context of HIV-1 has peaked, but their in vivo expression and regulation remains largely unexplored. Therefore, the present study examined

Externí odkaz: https://doaj.org/article/aa9f7ab41a874200800a959c52746e7c

On the whereabouts of SARS-CoV-2 in the human body: A systematic review.

Autor: Wim Trypsteen, Jolien Van Cleemput, Willem van Snippenberg, Sarah Gerlo, Linos Vandekerckhove

Publikováno v: PLoS Pathogens, Vol 16, Iss 10, p e1009037 (2020)

Since SARS-CoV-2 appeared in the human population, the scientific community has scrambled to gather as much information as possible to find good strategies for the containment and treatment of this pandemic virus. Here, we performed a systematic revi

Externí odkaz: https://doaj.org/article/a2b9d6cd545944ca9a875b0518c93592

A 3'-end capture sequencing method for high-throughput targeted gene expression profiling

Autor: Eric de Bony, Fien Gysens, Nurten Yigit, Jasper Anckaert, Celine Everaert, Eveline Vanden Eynde, Kimberly Verniers, Willem van Snippenberg, Wim Trypsteen, Pieter Mestdagh

Publikováno v: Biotechnology journalREFERENCES. 17(9)

Molecular phenotyping through shallow 3'-end RNA-sequencing workflows is increasingly applied in the context of large-scale chemical or genetic perturbation screens to study disease biology or support drug discovery. While these workflows enable accu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abd6a2886d7be6f9f61e65093625f3d
https://pubmed.ncbi.nlm.nih.gov/35535560

Organ-specific genome diversity of replication-competent SARS-CoV-2

Autor: Martin Lammens, Linos Vandekerckhove, Nick Vereecke, Liesbeth Couck, Willem van Snippenberg, Jan Vanrusselt, Thierry P P van den Bosch, Laurens Lambrechts, Janneke Cox, Sarah Gerlo, Jan H. von der Thüsen, Ruth Achten, Jolien Van Cleemput, Jo Van Dorpe, Hans Nauwynck, Amélie Dendooven, Ken R. Bracke, Ann Driessen, Piet Maes, Wim Trypsteen, Valentino D’Onofrio, Wim Van den Broeck, Sebastiaan Theuns

Publikováno v: Nature communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
NATURE COMMUNICATIONS
Nature Communications, 12(1):6612. Nature Publishing Group

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not always confined to the respiratory system, as it impacts people on a broad clinical spectrum from asymptomatic to severe systemic manifestations resulting in death. Further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2935271a4577a302e25149a33b5786ab
https://repository.uantwerpen.be/docstore/d:irua:10012