Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Willem M. H. Hoogaars"'
Autor:
Michèle M. G. Hillege, Ricardo A. Galli Caro, Carla Offringa, Gerard M. J. de Wit, Richard T. Jaspers, Willem M. H. Hoogaars
Publikováno v:
Cells, Vol 9, Iss 2, p 375 (2020)
Transforming Growth Factor β (TGF-β) is involved in fibrosis as well as the regulation of muscle mass, and contributes to the progressive pathology of muscle wasting disorders. However, little is known regarding the time-dependent signalling of TGF
Externí odkaz:
https://doaj.org/article/1ced9a20c5474ed5ad75b0efd4925e6a
Autor:
Michèle M G, Hillege, Andi, Shi, Ricardo A, Galli, Gang, Wu, Philippe, Bertolino, Willem M H, Hoogaars, Richard T, Jaspers
Publikováno v:
eLife. 11
In skeletal muscle, transforming growth factor-β (TGF-β) family growth factors, TGF-β1 and myostatin, are involved in atrophy and muscle wasting disorders. Simultaneous interference with their signalling pathways may improve muscle function; howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cb9bcf69e1f2cbd498f75d65faa32cb
https://pubmed.ncbi.nlm.nih.gov/35323108
https://pubmed.ncbi.nlm.nih.gov/35323108
Autor:
Songting Shi, Jie Cai, David J J de Gorter, Gonzalo Sanchez-Duffhues, Dwi U Kemaladewi, Willem M H Hoogaars, Annemieke Aartsma-Rus, Peter A C 't Hoen, Peter ten Dijke
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69096 (2013)
Fibrodysplasia ossificans progressiva (FOP) is a rare heritable disease characterized by progressive heterotopic ossification of connective tissues, for which there is presently no definite treatment. A recurrent activating mutation (c.617G→A; R206
Externí odkaz:
https://doaj.org/article/8b10ff0983c3452c99d42c526bccbfd9
Publikováno v:
Advances in experimental medicine and biology. 1088
Myostatin was identified more than 20 years ago as a negative regulator of muscle mass in mice and cattle. Since then, a wealth of studies have uncovered the potential involvement of myostatin in muscle atrophy and sparked interest in myostatin as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d70a323f2261630e440b88e92b046d92
https://pubmed.ncbi.nlm.nih.gov/30390252
https://pubmed.ncbi.nlm.nih.gov/30390252
Publikováno v:
Advances in experimental medicine and biology. 1088
Insulin-like growth factor 1 (IGF-1) is a key anabolic growth factor stimulating phosphatidylinositol 3-kinase (PI3K)/Akt signaling which is well known for regulating muscle hypertrophy. However, the role of IGF-1 in muscle atrophy is less clear. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22c69902c6fed1da2b97c5bd7ceae570
https://pubmed.ncbi.nlm.nih.gov/30390250
https://pubmed.ncbi.nlm.nih.gov/30390250