Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Willem J. DE LANGE"'
Autor:
Kai-Chun Yang, MD, Astrid Breitbart, MD, Willem J. De Lange, PhD, Peter Hofsteen, PhD, Akiko Futakuchi-Tsuchida, BS, Joy Xu, MSE, Cody Schopf, BS, Maria V. Razumova, PhD, Alex Jiao, PhD, Robert Boucek, MD, Lil Pabon, PhD, Hans Reinecke, PhD, Deok-Ho Kim, PhD, J. Carter Ralphe, MD, Michael Regnier, PhD, Charles E. Murry, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 728-740 (2018)
Summary: A novel myosin heavy chain 7 mutation (E848G) identified in a familial cardiomyopathy was studied in patient-specific induced pluripotent stem cell–derived cardiomyocytes. The cardiomyopathic human induced pluripotent stem cell–derived c
Externí odkaz:
https://doaj.org/article/55e66573abed49ff8e6ea65cc4f0d1b0
Autor:
Emily Farrell, Annie E. Armstrong, Adrian C. Grimes, Francisco J. Naya, Willem J. de Lange, J. Carter Ralphe
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Rationale: With a prevalence of 1 in 200 individuals, hypertrophic cardiomyopathy (HCM) is thought to be the most common genetic cardiac disease, with potential outcomes that include severe hypertrophy, heart failure, and sudden cardiac death (SCD).
Externí odkaz:
https://doaj.org/article/aa5f89a96b0e415887f32229e9a503f7
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Rationale: Hypertrophic cardiomyopathy (HCM) occurs in ~0.5% of the population and is a leading cause of sudden cardiac death (SCD) in young adults. Cardiomyocyte hypertrophy has been the accepted mechanism for cardiac enlargement in HCM, but the ear
Externí odkaz:
https://doaj.org/article/9f39d2ae1b2b4d36b124aec904b277e3
Autor:
Willem J. De Lange, Emily T. Farrell, Jonathan J. Hernandez, Alana Stempien, Caroline R. Kreitzer, Derek R. Jacobs, Dominique L. Petty, Richard L. Moss, Wendy C. Crone, J. Carter Ralphe
Publikováno v:
Journal of General Physiology. 155
Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM, while homozygous carriers present with early onset HCM that rapidly progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f148b02a41d4bfbb7519538279deb4
https://doi.org/10.1085/jgp.202213204
https://doi.org/10.1085/jgp.202213204
Autor:
Willem J De Lange
Publikováno v:
Groundwater. 60:319-329
Observation of dispersion in field situations has left three issues that may be better understood by applying advective transport phenomena. (1) In some experiments, the longitudinal dispersivity becomes constant with increasing pathlength and in oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fcd2c2bb29f138ffb7d260059f1a33
https://doi.org/10.1111/gwat.13151
https://doi.org/10.1111/gwat.13151
Autor:
Caroline R Kreitzer, Emily T. Farrell, Willem J. de Lange, J. Carter Ralphe, Alexey V. Glukhov, Di Lang, Derek R Jacobs
Publikováno v:
Am J Physiol Heart Circ Physiol
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) may provide an important bridge between animal models and the intact human myocardium. Fulfilling this potential is hampered by their relative immaturity, leading to poor phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca09bccb5adb86051a95367282e53b1
https://doi.org/10.1152/ajpheart.00941.2020
https://doi.org/10.1152/ajpheart.00941.2020
Publikováno v:
Journal of Contemporary Management. 18:173-193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a07a0dadf225818dbb81979b3a25b7c4
https://doi.org/10.35683/jcm20087.101
https://doi.org/10.35683/jcm20087.101
Autor:
Hannah Karp, J. Carter Ralphe, Zachery R. Gregorich, Willem J. de Lange, Timothy J. Kamp, Ying Ge, Elizabeth F. Bayne, Trisha Tucholski, Wenxuan Cai, Joshua L. Hermsen, Sean J. McIlwain, Amy Li, Steven B. Marston, Stanford D. Mitchell, Petr G. Vikhorev, Zachary Hite, Cristobal G. dos Remedios, Max Wrobbel, Sean Lal, Takushi Kohmoto, Richard L. Moss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Hypertrophic cardiomyopathy (HCM) is a common genetic heart disease and a leading cause of sudden cardiac death in young adults. HCM has been linked to mutations in genes encoding sarcomeric proteins, but how different mutations can resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6425102d14355d69e24e9eb68fbd7321
https://doi.org/10.1073/pnas.2006764117
https://doi.org/10.1073/pnas.2006764117
Autor:
Daniel G.P. Turner, Willem J. De Lange, Di Lang, Gina Kim, Yanlong Zhu, Ying Ge, Timothy J. Kamp, John C. Ralphe, Alexey V. Glukhov
Publikováno v:
Biophysical Journal. 122:413a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a2d3e6ec91989b9098fcc21be1cbc0
https://doi.org/10.1016/j.bpj.2022.11.2245
https://doi.org/10.1016/j.bpj.2022.11.2245
Publikováno v:
Circulation. 144
Cardiac myosin binding protein C (cMyBP-C) is a sarcomeric protein important in the regulation of cardiac contraction through its phosphorylation-dependent interactions with myosin heavy chain and actin. MYBPC3, the gene encoding cMyBP-C, contains th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea5972ba9c73529454fb5b19a93f015
https://doi.org/10.1161/circ.144.suppl_1.14011
https://doi.org/10.1161/circ.144.suppl_1.14011