Oxygenation Threshold Derived from Near-Infrared Spectroscopy: Reliability and Its Relationship with the First Ventilatory Threshold.

Autor: Stephan van der Zwaard, Richard T Jaspers, Ilse J Blokland, Chantal Achterberg, Jurrian M Visser, Anne R den Uil, Mathijs J Hofmijster, Koen Levels, Dionne A Noordhof, Arnold de Haan, Jos J de Koning, Willem J van der Laarse, Cornelis J de Ruiter

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162914 (2016)

BACKGROUND:Near-infrared spectroscopy (NIRS) measurements of oxygenation reflect O2 delivery and utilization in exercising muscle and may improve detection of a critical exercise threshold. PURPOSE:First, to detect an oxygenation breakpoint (Δ[O2HbM

Externí odkaz: https://doaj.org/article/ce90e12598234c3281acdc1e04c8a982

Metabolic Cost of Activation and Mechanical Efficiency of Mouse Soleus Muscle Fiber Bundles During Repetitive Concentric and Eccentric Contractions

Autor: Koen K. Lemaire, Richard T. Jaspers, Dinant A. Kistemaker, A. J. “Knoek” van Soest, Willem J. van der Laarse

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Currently available data on the energetics of isolated muscle preparations are based on bouts of less than 10 muscle contractions, whereas metabolic energy consumption is mostly relevant during steady state tasks such as locomotion. In this study we

Externí odkaz: https://doaj.org/article/b86599a392274d5b981189f80e0ab4a1

Increased MAO-A activity promotes progression of pulmonary arterial hypertension

Autor: Denielli da Silva Goncalves Bos, Robert Szulcek, Frances S. de Man, Xiaoke Pan, Maria Catalina Gomez-Puerto, Willem J. van der Laarse, Ingrid Schalij, Anton Vonk Noordegraaf, Harm Jan Bogaard, Roy E. J. Schiepers, Eva L. Peters, Stine Andersen, Asger Andersen, Marie-José Goumans, Xiao-Qing Sun, Julie Birkmose Axelsen, Kondababu Kurakula

Publikováno v: Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E, Andersen, A, Goumans, M-J, Vonk Noordegraaf, A, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension ', American Journal of Respiratory Cell and Molecular Biology (Online), vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC

Monoamine oxidases (MAOs), a class of enzymes bound to the outer mitochondrial membrane, are important sources of reactive oxygen species. Increased MAO-A activity in endothelial cells and cardiomyocytes contributes to vascular dysfunction and progre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17fc29d183ab7e6ceb1004764998e13
https://doi.org/10.1165/rcmb.2020-0105oc

Rapid Quantification of Myocardial Fibrosis: A New Macro-Based Automated Analysis

Autor: Awal M. Hadi, Koen T. B. Mouchaers, Ingrid Schalij, Katrien Grunberg, Gerrit A. Meijer, Anton Vonk-Noordegraaf, Willem J. van der Laarse, Jeroen A. M. Beliën

Publikováno v: Analytical Cellular Pathology, Vol 33, Iss 5-6, Pp 257-269 (2010)

Background: Fibrosis is associated with various cardiac pathologies and dysfunction. Current quantification methods are time-consuming and laborious. We describe a semi-automated quantification technique for myocardial fibrosis and validated this usi

Externí odkaz: https://doaj.org/article/15348ad419504437b5cdd07bafb52022

Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

Autor: Judith Klumperman, Joshua Craiger Peterson, Willem J van der Laarse, Wendy Noort, Richard T. Jaspers, Mauro J. Muraro, Kenneth D. Poss, Eldad Tzahor, Phong D. Nguyen, Avraham Shakked, George Posthuma, Gilbert Weidinger, Alla Aharonov, Fabian Kruse, Federico Tessadori, Alexander van Oudenaarden, Alberto Bertozzi, Adam R. Shoffner, Dennis E. M. de Bakker, Hessel Honkoop, Cecilia de Heus, Laurence Garric, Dominic Grün, Jeroen Bakkers

Publikováno v: eLife
Honkoop, H, de Bakker, D E M, Aharonov, A, Kruse, F, Shakked, A, Nguyen, P D, de Heus, C, Garric, L, J Muraro, M, Shoffner, A, Tessadori, F, Peterson, J C, Noort, W, Bertozzi, A, Weidinger, G, Posthuma, G, Grün, D, van der Laarse, W J, Klumperman, J, Jaspers, R T, Poss, K D, van Oudenaarden, A, Tzahor, E & Bakkers, J 2019, ' Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart ', eLife, vol. 8, e50163 . https://doi.org/10.7554/eLife.50163
eLife, Vol 8 (2019)
eLife, 8:e50163. eLife Sciences Publications Limited
eLife, 8. eLife Sciences Publications
eLife, 8:e50163. eLife Sciences Publications

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to replace the lost myocar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee66e2461ec6478fd464605d47b5f8a0
https://hdl.handle.net/20.500.11755/15cf795e-92c4-48d5-902a-d33de79eb986