Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Willem G.E.J. Schoonen"'
Autor:
Peter Olinga, Suresh Vatakuti, Marieke L.G. Elferink, Geny M. M. Groothuis, Willem G.E.J. Schoonen
Publikováno v:
Toxicology in Vitro, 29(5), 1012-1020. PERGAMON-ELSEVIER SCIENCE LTD
In rat in vivo, both paracetamol (APAP) and carbon tetrachloride (CCl4) induce liver necrosis, but long-term treatment with CCl4, in contrast to paracetamol, causes liver fibrosis. The aim of this study was to perform transcriptomic analysis to compa
Publikováno v:
Journal of Applied Toxicology. 33:399-409
Most of the current in vitro carcinogenicity assays assess the potential carcinogenic properties of chemicals through the detection of inflicted DNA damage or subsequent chromosome damage and gene mutations. Unfortunately, these assays generally do n
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 154(1)
Blood sampling during juvenile rat toxicology studies is required to determine the toxicokinetic (TK) profile of compounds. Juvenile rats are too small to undergo repeated blood sampling using conventional methods, which collect 200-300 μl blood at
Publikováno v:
Toxicology in Vitro. 26:511-525
In vitro toxicity screening can reduce the attrition rate of drug candidates in the pharmaceutical industry in the early development process. The focus in this study is to compare the sensitivity for cytotoxicity of a time-resolved fluoro metric oxyg
Publikováno v:
Toxicology in Vitro. 25:1870-1882
Drug-induced phospholipidosis is marked by an excessive accumulation of phospholipids in lysosomes which can occur after exposure to cationic amphiphilic drugs. Phospholipidosis is considered as an adverse side effect and may delay or negatively affe
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 724:7-21
In the present study an automated image analysis assisted in vitro micronucleus assay was developed with the rodent cell line CHO-k1 and the human hepatoma cell line HepG2, which are both commonly used in regulatory genotoxicity assays. The HepG2 cel
Publikováno v:
Toxicology in Vitro. 25:545-554
The PR CALUX® cell line is a stably transfected human U2-OS cell line expressing the human PR and a luciferase reporter construct containing three progesterone-responsive elements coupled to a minimal promoter. The validity of this assay has been st
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 696:21-40
Four different mechanism-based high-throughput luciferase-reporter assays were developed in human HepG2 cells, which contain phase I and II metabolic activity and a functionally active p53 protein. The promoter regions of RAD51C and Cystatin A, as we
Publikováno v:
Archives of Toxicology. 82:909-921
Strong activation of the AhR can lead to various toxic effects such as (non-genotoxic) carcinogenicity. Moreover, drug-drug interactions by non- or competitive inhibition of CYP1A1 and 1A2 may cause adverse side effects. Normally the majority of toxi
Autor:
Willem G.E.J. Schoonen, Toine F.H. Bovee, Astrid R. M. Hamers, Marta Jorge Bento, Ad A. C. M. Peijnenburg
Publikováno v:
Analytical and Bioanalytical Chemistry, 390(4), 1111-1119
Analytical and Bioanalytical Chemistry 390 (2008) 4
Analytical and Bioanalytical Chemistry 390 (2008) 4
Recently we constructed yeast cells that either express the human estrogen receptor alpha or the human androgen receptor in combination with a consensus ERE or ARE repeat in the promoter region of a green fluorescent protein (yEGFP) read-out system.