Výsledky vyhledávání - "Willem G. van Aken"

Binding and inactivation of prostacyclin (PGI2) by human erythrocytes

Autor: Charles Willems, H. V. Stel, Jan A. van Mourik, Willem G. van Aken

Publikováno v: British Journal of Haematology. 54:43-52

Summary. Prostacyclin (PGI2), the most potent inhibitor of platelet aggregation known, is rapidly hydrolysed in aqueous solution at neutral pH to its inactive derivative 6-keto-PGF1α. In previous studies (Willems et al, 1979), we found that PGI2 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cae08d3485feea0beedcf2b2abf958ce
https://doi.org/10.1111/j.1365-2141.1983.00043.x

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Endothelialization of Crosslinked Albumin-heparin Gels

Autor: Gerard H.M. Engbers, Jan Feijen, Gert W. Bos, Willem G. van Aken, André A. Poot, Nicole M. Scharenborg, Tom Beugeling

Publikováno v: Thrombosis and haemostasis, 82(6), 1757-1763. Schattauer GmbH

SummaryCrosslinked gels of albumin as well as heparinized albumin gels, potential sealants of prosthetic vascular grafts, were studied with regard to in vitro stability, binding of basic fibroblast growth factor (bFGF) and cellular interactions. A sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68892e97ddcedef0f4a769da44b9771
https://doi.org/10.1055/s-0037-1614910

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Blood compatibility of surfaces with immobilized albumin-heparin conjugate and effect of endothelial cell seeding on platelet adhesion

Autor: Jan Feijen, Tom Beugeling, Gerard H.M. Engbers, Nicole M. Scharenborg, André A. Poot, Gert W. Bos, Willem G. van Aken

Publikováno v: Journal of biomedical materials research, 47(3), 279-291. Wiley

Endothelial cell (EC) seeding significantly improves the blood compatibility of artificial surfaces. Although a coating consisting of albumin and heparin (alb-hep) is a suitable substrate for seeded ECs, binding of ECs to the substrate further improv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2a2cf1e7202d618db6e9fb611fe96b
https://doi.org/10.1002/(sici)1097-4636(19991205)47:3<279::aid-jbm1>3.0.co

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Proliferation of endothelial cells on surface-immobilized albumin-heparin conjugate loaded with basic fibroblast growth factor

Autor: André A. Poot, Willem G. van Aken, Gert W. Bos, Nicole M. Scharenborg, Tom Beugeling, Jan Feijen, Gerard H.M. Engbers

Publikováno v: Journal of biomedical materials research, 44(33), 230-240. Wiley

Seeding of endothelial cells (ECs) on the luminal surface of small-diameter vascular grafts is a promising method to avoid occlusion of these prostheses. Immobilization of basic fibroblast growth factor (bFGF) to substrates used to coat or fill porou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a127f0249f30ee39631f95b15e646ebe
https://doi.org/10.1002/(sici)1097-4636(19990305)44:3<330::aid-jbm12>3.0.co

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The mechanisms of leukocyte removal by filtration

Autor: Jan Feijen, Anton Bruil, Willem G. van Aken, Tom Beugeling

Publikováno v: Transfusion medicine reviews, IX(2), 145-166. W.B. Saunders Ltd

ONVINCING evidence exists that blood transfusions are associated with deleterious effects caused by residual leukocytes in blood and blood components. These side effects include alloimmunization to histocompatibility antigens, transmission of viruses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea18cf5be561a2502df64879da9df440
https://doi.org/10.1016/s0887-7963(05)80053-7

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Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors

Autor: Chris G. Kruse, Mauro Maccarrone, Monica Bari, Sergio Oddi, Pascal Chameau, Taco R. Werkman, Qiluan Schaafsma-Zhao, Femke S. den Boon, Willem G. van Aken, Wytse J. Wadman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3534-3539. National Academy of Sciences

The endocannabinoid (eCB) system is widely expressed throughout the central nervous system (CNS) and the functionality of type-1 cannabinoid receptors in neurons is well documented. In contrast, there is little knowledge about type-2 cannabinoid rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74f2b882f982b8365a7dece46e00c09
http://hdl.handle.net/11697/155990

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In Vitro Leukocyte Adhesion to Modified Polyurethane Surfaces

Autor: J.G.A. Terlingen, Laura M. Brenneisen, Tom Beugeling, Willem G. van Aken, Jan Feijen, Anton Bruil

Publikováno v: Journal of Colloid and Interface Science. 165:72-81

The influence of substrate wettability on leukocyte adhesion was studied using a series of polyurethane films with different surface wettabilities, prepared by a two step gas plasma modification procedure. In the first step the films were made hydrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fd8d0b3750a32cdd9bbeee2b02bab8e
https://doi.org/10.1006/jcis.1994.1207

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Poly(ethyleneimine) modified filters for the removal of leukocytes from blood

Autor: Anton Bruil, Hieke A. Oosterom, Ingeborg Steneker, Bert J. M. Al, Tom Beugeling, Willem G. van Aken, Jan Feijen

Publikováno v: Journal of biomedical materials research, 27(10), 1253-1268. Wiley

Polyurethane membrane filters and filters coated with poly(ethyleneimine) were used to investigate the influence of leukocyte adhesion during filtration. Treatment of the filters with an aqueous solution of 1% (w/v) poly(ethyleneimine) (PEI) led to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c260d46ca5e574fd491799950150e1b0
https://doi.org/10.1002/jbm.820271006

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In vitro leucocyte adhesion to modified polyurethane surfaces

Autor: Willem G. van Aken, Tom Beugeling, J.G.A. Terlingen, Anton Bruil, Jan Feijen

Publikováno v: Biomaterials. 13:915-923

To study the effect of ionizable functional groups on the adhesion of leucocytes to surfaces, both poly(ethyleneimine) and poly(acrylic acid) were immobilized on polyurethane films, resulting in the introduction of amine and carboxylic acid groups, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80c7c0afbd58f86b92a30371bdf3a638
https://doi.org/10.1016/0142-9612(92)90114-4

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A three-dimensional model system to study the interactions between human leukocytes and endothelial cells

Autor: Jeannette M. Rentenaar, Willem G. van Aken, Jan A. van Mourik, Dirk Roos, B. C. Hakkert

Publikováno v: European Journal of Immunology. 20:2775-2781

Leukocyte adhesion to endothelial cells and migration into the subendothelial matrix was studied with a three-dimensional model system, consisting of human endothelial cells cultured on a loose collagen matrix. We developed a new method to separate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e20512f3e6af167134581182db81a
https://doi.org/10.1002/eji.1830201236

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