Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Willem F. van der Giesen"'
Autor:
Willem F. van der Giesen
Publikováno v:
Drug Information Journal. 27:81-85
The experience of the Dutch Medicines Evaluation Board as rapporteur in the concertation procedure has been a successful learning experience. We begin with informative discussions with the applicant in the presubmission phase, emphasizing close conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f9fb34a9d60a8672bcd23a29ae8c9df
https://doi.org/10.1177/009286159302700117
https://doi.org/10.1177/009286159302700117
Publikováno v:
International Journal of Pharmaceutics. 12:355-359
The susceptibility of coumarins to alkaline hydrolysis, resulting in the formation of cis-coumarinate (and subsequently trans-coumarinate) polyanions is well known (Decker and Becker, 1922; Garrett et al., 1971; Mattoo, 1957; Bowden et al., 19611; Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a81bfb606f44695f45e7d4f6c2861f0f
https://doi.org/10.1016/0378-5173(82)90107-7
https://doi.org/10.1016/0378-5173(82)90107-7
Autor:
Jaap Wilting, Willem F. van der Giesen
Publikováno v:
Biochemical Pharmacology. 32:281-285
The protein binding of warfarin in serum has been studied by means of circular dichroism and equilibrium dialysis. Evidence was found that the N-B transition of albumin, occurring around physiological pH, takes place not only in solutions of pure alb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81104aea57b718857f030ccd51d11426
https://doi.org/10.1016/0006-2952(83)90556-7
https://doi.org/10.1016/0006-2952(83)90556-7
Publikováno v:
International Journal of Pharmaceutics. 12:231-249
The pH-dependent distribution of weak acids in the octanol-water system was investigated. For a series of six 4-hydroxycoumarins, substituted at position 3, the apparent partition coefficient or the distribution coefficient, P app , was measured in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df1598577d8162ce776d001eb04785c5
https://doi.org/10.1016/0378-5173(82)90122-3
https://doi.org/10.1016/0378-5173(82)90122-3
Publikováno v:
Journal of Chromatography A. 237:199-213
The adsorptive behaviour of four supports in reversed-phase thin-layer chromatography was investigated. Oleyl alcohol was used as the stationary phase and methanol-water mixtures as the mobile phase. A series of 4-hydroxycoumarins were used as test c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c618736d173bc2e8d875530f9798b28e
https://doi.org/10.1016/s0021-9673(00)83227-6
https://doi.org/10.1016/s0021-9673(00)83227-6
Publikováno v:
Biochemical pharmacology. 30(10)
The effect of chloride on the binding of warfarin to human serum albumin between pH 6 and 9.5 has been studied by circular dichroism and equilibrium dialysis. The molar ellipticity of the warfarin-albumin complex is hardly affected by chloride ions w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83633c2aeafb8d422fa0b9a3147f59c1
https://pubmed.ncbi.nlm.nih.gov/7259790
https://pubmed.ncbi.nlm.nih.gov/7259790