Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Willeke Van Roon-Mom"'
Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
Autor:
Cathrin E. Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, Bert van het Hof, Ruud D. Fontijn, Susanne M. A. van der Pol, Laura Michalick, Wolfgang M. Kuebler, Boyd Kenkhuis, Willeke van Roon-Mom, Wolfgang Liedtke, Britta Engelhardt, Gijs Kooij, Maarten E. Witte, Helga E. de Vries
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Blood–brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple sclerosis (MS). Ways to reinstate BBB function and subsequently limit neuroinflammation pre
Externí odkaz:
https://doaj.org/article/20142c75d08c47bfb64eb7ea8bb2e9c3
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Antisense oligonucleotides (ASOs) are incredibly versatile molecules that can be designed to specifically target and modify RNA transcripts to slow down or halt rare genetic disease progression. They offer the potential to target groups of p
Externí odkaz:
https://doaj.org/article/5921451646084845bc63da2e688a2b76
Autor:
Elsa C. Kuijper, Maurice Overzier, Ernst Suidgeest, Oleh Dzyubachyk, Cécile Maguin, Jean-Baptiste Pérot, Julien Flament, Yavuz Ariyurek, Hailiang Mei, Ronald A.M. Buijsen, Louise van der Weerd, Willeke van Roon-Mom
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106368- (2024)
In Huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (HTT) protein. By modifying the HTT protein, we aim to reduce proteolytic cleavage and ameliorate the consequences of muta
Externí odkaz:
https://doaj.org/article/0b4874be3df4497fb539494749184266
Autor:
Suzan M Hammond, Annemieke Aartsma‐Rus, Sandra Alves, Sven E Borgos, Ronald A M Buijsen, Rob W J Collin, Giuseppina Covello, Michela A Denti, Lourdes R Desviat, Lucía Echevarría, Camilla Foged, Gisela Gaina, Alejandro Garanto, Aurelie T Goyenvalle, Magdalena Guzowska, Irina Holodnuka, David R Jones, Sabine Krause, Taavi Lehto, Marisol Montolio, Willeke Van Roon‐Mom, Virginia Arechavala‐Gomeza
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-23 (2021)
Abstract Nucleic acid‐based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed products based
Externí odkaz:
https://doaj.org/article/76e52486fd764de6bb07b4e5106b079a
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Huntington’s disease (HD) is caused by an expansion mutation of a CAG repeat in exon 1 of the huntingtin (HTT) gene, that encodes an expanded polyglutamine tract in the HTT protein. HD is characterized by progressive psychiatric and cognitive sympt
Externí odkaz:
https://doaj.org/article/197bfe0599bf4cfe876234314abb0845
Autor:
Marjolein Bulk, Ingrid Hegeman-Kleinn, Boyd Kenkhuis, Ernst Suidgeest, Willeke van Roon-Mom, Jan Lewerenz, Sjoerd van Duinen, Itamar Ronen, Louise van der Weerd
Publikováno v:
NeuroImage: Clinical, Vol 28, Iss , Pp 102498- (2020)
Previous MRI studies consistently reported iron accumulation within the striatum of patients with Huntington’s disease (HD). However, the pattern and origin of iron accumulation is poorly understood. This study aimed to characterize the histopathol
Externí odkaz:
https://doaj.org/article/16f59392ae9d4403a65794b77d7eafb2
Autor:
Simin Mahinrad, Marjolein Bulk, Isabelle van der Velpen, Ahmed Mahfouz, Willeke van Roon-Mom, Neal Fedarko, Sevil Yasar, Behnam Sabayan, Diana van Heemst, Louise van der Weerd
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Animal studies suggest the involvement of natriuretic peptides (NP) in several brain functions that are known to be disturbed during Alzheimer’s disease (AD). However, it remains unclear whether such findings extend to humans. In this study, we aim
Externí odkaz:
https://doaj.org/article/e8377b27b89940c4a06b1046167459cc
Autor:
Jasper Ouwerkerk, Stephanie Feleus, Kasper van der Zwaan, Yunlei Li, Marco Roos, Willeke van Roon-Mom, Susanne de Bot, Katherine Wolstencroft, Eleni Mina
Background: In biomedicine, machine learning (ML) has proven beneficial for the prognosis and diagnosis of different diseases, including cancer and neurodegenerative disorders. For rare diseases, however, the requirement for large datasets often prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be228784d89a609cc073f421cddcdf55
https://doi.org/10.21203/rs.3.rs-2648484/v1
https://doi.org/10.21203/rs.3.rs-2648484/v1
Autor:
Annemieke Aartsma-Rus, Willeke van Roon-Mom, Marlen Lauffer, Christine Siezen, Britt Duijndam, Tineke Coenen-de Roo, Rebecca Schüle, Matthis Synofzik, Holm Graessner
Publikováno v:
RNA 29(4), 446-454 (2023). doi:10.1261/rna.079540.122
Splice-modulating antisense oligonucleotides (ASOs) offer treatment options for rare neurological diseases, including those with very rare mutations, where patient-specific, individualized ASOs have to be developed. Inspired by the development of mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d05f57802f70ee534d3b4f2e7de8dbe
https://pub.dzne.de/record/257309
https://pub.dzne.de/record/257309
Autor:
Annemieke, Aartsma-Rus, Alejandro, Garanto, Willeke, van Roon-Mom, Erin M, McConnell, Victoria, Suslovitch, Winston X, Yan, Jonathan K, Watts, Timothy W, Yu
Publikováno v:
Nucleic acid therapeutics.
Antisense oligonucleotides (ASOs) can modulate pre-mRNA splicing. This offers therapeutic opportunities for numerous genetic diseases, often in a mutation-specific and sometimes even individual-specific manner. Developing therapeutic ASOs for as few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d19f24e2202c63305b6cb379df5b95b
https://pubmed.ncbi.nlm.nih.gov/36516128
https://pubmed.ncbi.nlm.nih.gov/36516128