Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Willeke A M, Blokx"'
Autor:
Annegien Broeks, Michel W J M Wouters, Georgina V Long, Richard A Scolyer, Christian U Blank, Judith M Versluis, Karijn P M Suijkerbuijk, Petros Dimitriadis, Joyce Sanders, James S Wilmott, Alexander Maxwell Menzies, Yvonne M Schrage, Stephanie A Blankenstein, Robert Elens, Willeke A M Blokx, Winan van Houdt, Alexander C J van Akkooi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background A substantial proportion of patients with macroscopic stage III melanoma do not benefit sufficiently from adjuvant anti-PD-1 therapy, as they either recur despite therapy or would never have recurred. To better inform adjuvant treatment se
Externí odkaz:
https://doaj.org/article/e0b90991b4304091afe1ffd233fc064c
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0256149 (2022)
IntroductionBecause of different therapeutic regimens for superficial and non-superficial basal cell carcinomas (BCCs), accurate histopathological examination of a punch biopsy to determine its subtype is essential. The aim of the current study was t
Externí odkaz:
https://doaj.org/article/07341cbf14d94ad2813ee05802552bf8
Autor:
Melissa M. de Meza, Willeke A. M. Blokx, Han J. Bonenkamp, Cristian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Marye J. Boers‐Sonderen, Jan Willem B. de Groot, John B. Haanen, Geke A. P. Hospers, Ellen W. Kapiteijn, Olivier J. van Not, Djura Piersma, Rozemarijn S. van Rijn, Marion A. Stevense‐Den Boer, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Alfons J. M. van den Eertwegh, Karijn P. M. Suijkerbuijk, Michel W. J. M. Wouters
Publikováno v:
International Journal of Cancer, 153, 2, pp. 389-398
de Meza, M M, Blokx, W A M, Bonenkamp, H J, Blank, C U, Aarts, M J B, van den Berkmortel, F W P J, Boers-Sonderen, M J, de Groot, J W B, Haanen, J B, Hospers, G A P, Kapiteijn, E W, van Not, O J, Piersma, D, van Rijn, R S, Stevense-den Boer, M A, van der Veldt, A A M, Vreugdenhil, G, van den Eertwegh, A J M, Suijkerbuijk, K P M & Wouters, M W J M 2023, ' Adjuvant treatment of in-transit melanoma : Narrowing the knowledge gap left by clinical trials ', International Journal of Cancer, vol. 153, no. 2, pp. 389-398 . https://doi.org/10.1002/ijc.34485
International Journal of Cancer, 153(2), 389-398. Wiley-Liss Inc.
International Journal of Cancer, 153, 389-398
International Journal of Cancer. Wiley
International Journal of Cancer, 153, 389-398. Wiley
de Meza, M M, Blokx, W A M, Bonenkamp, H J, Blank, C U, Aarts, M J B, van den Berkmortel, F W P J, Boers-Sonderen, M J, de Groot, J W B, Haanen, J B, Hospers, G A P, Kapiteijn, E W, van Not, O J, Piersma, D, van Rijn, R S, Stevense-den Boer, M A, van der Veldt, A A M, Vreugdenhil, G, van den Eertwegh, A J M, Suijkerbuijk, K P M & Wouters, M W J M 2023, ' Adjuvant treatment of in-transit melanoma : Narrowing the knowledge gap left by clinical trials ', International Journal of Cancer, vol. 153, no. 2, pp. 389-398 . https://doi.org/10.1002/ijc.34485
International Journal of Cancer, 153(2), 389-398. Wiley-Liss Inc.
International Journal of Cancer, 153, 389-398
International Journal of Cancer. Wiley
International Journal of Cancer, 153, 389-398. Wiley
Contains fulltext : 292870.pdf (Publisher’s version ) (Open Access) Few clinical trials address efficacy of adjuvant systemic treatment in patients with in-transit melanoma (ITM). This study describes adjuvant systemic therapy of ITM patients beyon
Autor:
Isabella A. J. van Duin, Sjoerd G. Elias, Alfonsus J. M. van den Eertwegh, Jan Willem B. de Groot, Willeke A. M. Blokx, Paul J. van Diest, Tim Leiner, Joost J. C. Verhoeff, Rik J. Verheijden, Olivier J. van Not, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Christian U. Blank, John B. A. G. Haanen, Geke A. P. Hospers, Anna M. Kamphuis, Djura Piersma, Rozemarijn S. van Rijn, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Michel W. J. M. Wouters, Marion A. M. Stevense‐den Boer, Marye J. Boers‐Sonderen, Ellen Kapiteijn, Karijn P. M. Suijkerbuijk
Publikováno v:
van Duin, I A J, Elias, S G, van den Eertwegh, A J M, de Groot, J W B, Blokx, W A M, van Diest, P J, Leiner, T, Verhoeff, J J C, Verheijden, R J, van Not, O J, Aarts, M J B, van den Berkmortel, F W P J, Blank, C U, Haanen, J B A G, Hospers, G A P, Kamphuis, A M, Piersma, D, van Rijn, R S, van der Veldt, A A M, Vreugdenhil, G, Wouters, M W J M, Stevense-den Boer, M A M, Boers-Sonderen, M J, Kapiteijn, E & Suijkerbuijk, K P M 2023, ' Time interval from primary melanoma to first distant recurrence in relation to patient outcomes in advanced melanoma ', International Journal of Cancer, vol. 152, no. 12, pp. 2493-2502 . https://doi.org/10.1002/ijc.34479
International Journal of Cancer, 152(12), 2493-2502. Wiley
International Journal of Cancer, 152(12), 2493-2502. Wiley-Liss Inc.
International Journal of Cancer, 152(12), 2493-2502. Wiley
International Journal of Cancer, 152(12), 2493-2502. Wiley-Liss Inc.
Since the introduction of BRAF(/MEK) inhibition and immune checkpoint inhibition (ICI), the prognosis of advanced melanoma has greatly improved. Melanoma is known for its remarkably long time to first distant recurrence (TFDR), which can be decades i
Autor:
Bart Sturm, David Creytens, Jan Smits, Ariadne H. A. G. Ooms, Erik Eijken, Eline Kurpershoek, Heidi V. N. Küsters-Vandevelde, Carla Wauters, Willeke A. M. Blokx, Jeroen A. W. M. van der Laak
Publikováno v:
Diagnostics, Vol 12, Iss 2, p 436 (2022)
An increasing number of pathology laboratories are now fully digitised, using whole slide imaging (WSI) for routine diagnostics. WSI paves the road to use artificial intelligence (AI) that will play an increasing role in computer-aided diagnosis (CAD
Externí odkaz:
https://doaj.org/article/0b5b8f2b0293426b868d9bb8ba690804
Autor:
Olivier J. van Not, Thijs T. Wind, Rawa K. Ismail, Arkajyoti Bhattacharya, Mathilde Jalving, Christian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Marye J. Boers-Sonderen, Alfonsus J. M. van den Eertwegh, Jan Willem B. de Groot, John B. Haanen, Ellen Kapiteijn, Manja Bloem, Djura Piersma, Rozemarijn S. van Rijn, Marion Stevense-den Boer, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Michel W. J. M. Wouters, Willeke A. M. Blokx, Karijn P. M. Suijkerbuijk, Rudolf S. N. Fehrmann, Geke A. P. Hospers
Publikováno v:
Cancers, 15(11):2922. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 15, 11
Cancers, 15
van Not, O J, Wind, T T, Ismail, R K, Bhattacharya, A, Jalving, M, Blank, C U, Aarts, M J B, van den Berkmortel, F W P J, Boers-Sonderen, M J, van den Eertwegh, A J M, de Groot, J W B, Haanen, J B, Kapiteijn, E, Bloem, M, Piersma, D, van Rijn, R S, Stevense-den Boer, M, van der Veldt, A A M, Vreugdenhil, G, Wouters, M W J M, Blokx, W A M, Suijkerbuijk, K P M, Fehrmann, R S N & Hospers, G A P 2023, ' A Survival Tree of Advanced Melanoma Patients with Brain Metastases Treated with Immune Checkpoint Inhibitors ', Cancers, vol. 15, no. 11, 2922 . https://doi.org/10.3390/cancers15112922
Cancers; Volume 15; Issue 11; Pages: 2922
Cancers, 15, 11
Cancers, 15
van Not, O J, Wind, T T, Ismail, R K, Bhattacharya, A, Jalving, M, Blank, C U, Aarts, M J B, van den Berkmortel, F W P J, Boers-Sonderen, M J, van den Eertwegh, A J M, de Groot, J W B, Haanen, J B, Kapiteijn, E, Bloem, M, Piersma, D, van Rijn, R S, Stevense-den Boer, M, van der Veldt, A A M, Vreugdenhil, G, Wouters, M W J M, Blokx, W A M, Suijkerbuijk, K P M, Fehrmann, R S N & Hospers, G A P 2023, ' A Survival Tree of Advanced Melanoma Patients with Brain Metastases Treated with Immune Checkpoint Inhibitors ', Cancers, vol. 15, no. 11, 2922 . https://doi.org/10.3390/cancers15112922
Cancers; Volume 15; Issue 11; Pages: 2922
Contains fulltext : 293454.pdf (Publisher’s version ) (Open Access) The efficacy of immune checkpoint inhibitors (ICIs) in patients with advanced melanoma that develop brain metastases (BM) remains unpredictable. In this study, we aimed to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcaef79c1a9e25c917f0c8902b4dea0
https://research.vumc.nl/en/publications/3986ca38-c595-4d53-a8ce-8e61d59ddcb4
https://research.vumc.nl/en/publications/3986ca38-c595-4d53-a8ce-8e61d59ddcb4
Autor:
Gosse J. Adema, Cornelis J. A. Punt, Carl G. Figdor, I. Jolanda M. de Vries, Kris Thielemans, Roel Mus, Danita H. Schuurhuis, Tjitske Duiveman-de Boer, Joannes F. M. Jacobs, Willeke A. M. Blokx, Michelle M. van Rossum, Johannes H. W. de Wilt, Alexandra J. Croockewit, W. Joost Lesterhuis, Kalijn Bol, Gerty Schreibelt, Erik H. J. G. Aarntzen
PDF file, 96K, Detection of tumor-specific T cells in SKIL cultures does not require challenge with defined epitopes. Tetramer analysis of SKILs cultured from biopsies of DTH reactions to DCs pulsed with tumor peptides (upper plots) or DCs electropor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b4ecc83c583c748182584f602a6fdd
https://doi.org/10.1158/1078-0432.22454442.v1
https://doi.org/10.1158/1078-0432.22454442.v1
Autor:
Gosse J. Adema, Cornelis J. A. Punt, Carl G. Figdor, I. Jolanda M. de Vries, Kris Thielemans, Roel Mus, Danita H. Schuurhuis, Tjitske Duiveman-de Boer, Joannes F. M. Jacobs, Willeke A. M. Blokx, Michelle M. van Rossum, Johannes H. W. de Wilt, Alexandra J. Croockewit, W. Joost Lesterhuis, Kalijn Bol, Gerty Schreibelt, Erik H. J. G. Aarntzen
Purpose: Electroporation of dendritic cells (DC) with mRNA encoding tumor-associated antigens (TAA) has multiple advantages compared to peptide loading. We investigated the immunologic and clinical responses to vaccination with mRNA-electroporated DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0f20607083d68d6b75c913531bcc4e
https://doi.org/10.1158/1078-0432.c.6522750.v1
https://doi.org/10.1158/1078-0432.c.6522750.v1
Autor:
Gosse J. Adema, Cornelis J. A. Punt, Carl G. Figdor, I. Jolanda M. de Vries, Kris Thielemans, Roel Mus, Danita H. Schuurhuis, Tjitske Duiveman-de Boer, Joannes F. M. Jacobs, Willeke A. M. Blokx, Michelle M. van Rossum, Johannes H. W. de Wilt, Alexandra J. Croockewit, W. Joost Lesterhuis, Kalijn Bol, Gerty Schreibelt, Erik H. J. G. Aarntzen
PDF file, 149K, CONSORT flow chart.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595a4d8dee7924abc9129d7e8cfd7422
https://doi.org/10.1158/1078-0432.22454448
https://doi.org/10.1158/1078-0432.22454448
Autor:
Gosse J. Adema, Cornelis J. A. Punt, Carl G. Figdor, I. Jolanda M. de Vries, Kris Thielemans, Roel Mus, Danita H. Schuurhuis, Tjitske Duiveman-de Boer, Joannes F. M. Jacobs, Willeke A. M. Blokx, Michelle M. van Rossum, Johannes H. W. de Wilt, Alexandra J. Croockewit, W. Joost Lesterhuis, Kalijn Bol, Gerty Schreibelt, Erik H. J. G. Aarntzen
PDF file, 1359K, Vaccine characteristics of first cycle of all patients. (A) Expression of HLA-ABC, HLA-DR/DP, HLA-DQ, CD80, CD86, CD83, and CCR7 was analyzed by flow cytometry. (B) Tumor antigen expression by DCs 2-4 hrs after electroporation with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9972bd46e8e67d96947535baab7380c
https://doi.org/10.1158/1078-0432.22454445
https://doi.org/10.1158/1078-0432.22454445