Circulating microRNA profile of long-lived Okinawans identifies novel potential targets for optimizing lifespan and health span.

Autor: Noureddine S; University of Central Florida College of Medicine, Burnett School of Biomedical Sciences, Orlando, Florida, USA., Schneider A; Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil., Strader S; University of Central Florida College of Medicine, Burnett School of Biomedical Sciences, Orlando, Florida, USA., Zhu X; University of Central Florida College of Medicine, Burnett School of Biomedical Sciences, Orlando, Florida, USA., Dhahbi J; Department of Medical Education, School of Medicine, California University of Science & Medicine, Colton, California, USA., Allsopp R; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA.; Center of Biomedical Research Excellence for Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, USA.; Okinawa Research Center for Longevity Science, Urasoe, Japan., Willcox DC; Center of Biomedical Research Excellence for Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, USA.; Okinawa Research Center for Longevity Science, Urasoe, Japan.; Department of Human Welfare, Okinawa International University, Ginowan, Japan., Donlon TA; Center of Biomedical Research Excellence for Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, USA.; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA., Shimabukuro M; Okinawa Research Center for Longevity Science, Urasoe, Japan.; Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, School of Medicine, Fukushima, Japan., Higa M; Diabetes and Life-Style Related Disease Center, Tomishiro Central Hospital, Tomishiro, Japan., Suzuki M; Okinawa Research Center for Longevity Science, Urasoe, Japan., Torigoe T; Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA., Ashiqueali S; University of Central Florida College of Medicine, Burnett School of Biomedical Sciences, Orlando, Florida, USA., Yadav H; USF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, Florida, USA., Willcox BJ; Center of Biomedical Research Excellence for Translational Research on Aging, Kuakini Medical Center, Honolulu, Hawaii, USA.; Okinawa Research Center for Longevity Science, Urasoe, Japan.; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawai'i, Honolulu, Hawaii, USA., Masternak MM; University of Central Florida College of Medicine, Burnett School of Biomedical Sciences, Orlando, Florida, USA.; Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland.

Publikováno v: Aging cell [Aging Cell] 2024 Aug; Vol. 23 (8), pp. e14191. Date of Electronic Publication: 2024 May 15.

Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans.

Autor: Torigoe TH; Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA. trevorht@hawaii.edu., Willcox DC; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.; Department of Human Welfare, Okinawa International University, Ginowan, Okinawa, Japan.; Okinawa Research Center for Longevity Science, Urasoe, Okinawa, Japan.; Department of Research, Kuakini Medical Center, Honolulu, HI, USA., Shimabukuro M; Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.; Diabetes and Life-Style Related Disease Center, Tomishiro Central Hospital, Tomishiro, Okinawa, Japan., Higa M; Diabetes and Life-Style Related Disease Center, Tomishiro Central Hospital, Tomishiro, Okinawa, Japan., Gerschenson M; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA., Andrukhiv A; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA., Suzuki M; Okinawa Research Center for Longevity Science, Urasoe, Okinawa, Japan., Morris BJ; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.; Department of Research, Kuakini Medical Center, Honolulu, HI, USA.; School of Medical Sciences, University of Sydney, Sydney, NSW, Australia., Chen R; Department of Research, Kuakini Medical Center, Honolulu, HI, USA., Gojanovich GS; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA., Allsopp RC; Institute for Biogenesis Research, Department of Anatomy, Biochemistry, and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA. allsopp@hawaii.edu.; Okinawa Research Center for Longevity Science, Urasoe, Okinawa, Japan. allsopp@hawaii.edu., Willcox BJ; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.; Okinawa Research Center for Longevity Science, Urasoe, Okinawa, Japan.; Department of Research, Kuakini Medical Center, Honolulu, HI, USA.

Publikováno v: Npj aging [NPJ Aging] 2024 Mar 08; Vol. 10 (1), pp. 18. Date of Electronic Publication: 2024 Mar 08.

FOXO3, a Resilience Gene: Impact on Lifespan, Healthspan, and Deathspan.

Autor: Donlon TA; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA., Morris BJ; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.; School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia., Masaki KH; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA., Chen R; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA., Davy PMC; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii, USA., Kallianpur KJ; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA., Nakagawa K; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Neuroscience Institute, The Queen's Medical Center, Honolulu, Hawaii, USA.; Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA., Owens JB; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii, USA., Willcox DC; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.; Department of Human Welfare, Okinawa International University, Ginowan, Okinawa, Japan., Allsopp RC; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii, USA., Willcox BJ; Center of Biomedical Research Excellence for Translational Research on Aging and Department of Research, Kuakini Medical Center, Honolulu, Hawaii, USA.; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.

Publikováno v: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2022 Aug 12; Vol. 77 (8), pp. 1479-1484.

Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels.

Autor: Frankum R; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK., Jameson TSO; College of Life and Environmental Sciences, University of Exeter, Exeter, UK., Knight BA; NIHR Exeter Clinical Research Facility, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Stephens FB; College of Life and Environmental Sciences, University of Exeter, Exeter, UK., Wall BT; College of Life and Environmental Sciences, University of Exeter, Exeter, UK., Donlon TA; Honolulu Heart Program (HHP)/Honolulu-Asia Aging Study (HAAS), Department of Research, Kuakini Medical Center, Honolulu, HI, 96817, USA.; Departments of Cell & Molecular Biology and Pathology, University of Hawaii, Honolulu, HI, 96813, USA., Torigoe T; Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA., Willcox BJ; Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, 96817, USA.; Department of Research, Kuakini Medical Center, Honolulu, HI, 96817, USA., Willcox DC; Department of Research, Kuakini Medical Center, Honolulu, HI, 96817, USA.; Okinawa International University, Okinawa, Japan., Allsopp RC; Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA., Harries LW; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Barrack Road, Exeter, EX2 5DW, UK. L.W.Harries@exeter.ac.uk.

Publikováno v: GeroScience [Geroscience] 2022 Apr; Vol. 44 (2), pp. 1169-1170.

Interaction between FOXO1A-209 Genotype and Tea Drinking is Significantly Associated with Reduced Mortality at Advanced Ages

Autor: Ming Q, Xiao-Li Tian, Yi Zeng, Xiaomin Liu, Ting Ni, Michael W. Lutz, Qihua Tan, Lei Feng, Jianxin Li, Li Y, Jiehua Lu, James W. Vaupel, Yang Z, Chao Nie, Willcox Dc, Elizabeth R. Hauser, Bradley J. Willcox, William K. Gottschalk, Lars Bolund, Simon G. Gregory, Huashuai Chen, Wei Tao, Junxia Min, Anatoli I. Yashin, Jun Gu, Rongping Ruan, Kenneth C. Land, Huanming Yang, Zhang F

Publikováno v: Zeng, Y, Chen, H, Ni, T, Ruan, R, Nie, C, Liu, X, Feng, L, Zhang, F, Lu, J, Li, J, Li, Y, Tao, W, Gottschalk, W, Lutz, M, Land, K, Yashin, A I, Tan, Q, Yang, Z, Bolund, L, Qi, M, Yang, H, Min, J, Willcox, C D, Willcox, B, Gu, J, Hauser, E, Tian, X-L & Vaupel, J W 2016, ' Interaction between FOXO1A-209 Genotype and Tea Drinking is Significantly Associated with Reduced Mortality at Advanced Ages ', Rejuvenation Research, vol. 19, no. 3, pp. 195-203 . https://doi.org/10.1089/rej.2015.1737
Zeng, Y, Chen, H, Ni, T, Ruan, R, Nie, C, Liu, X, Feng, L, Zhang, F, Lu, J, Li, J, Li, Y, Tao, W, Gregory, S G, Gottschalk, W, Lutz, M, Land, K, Yashin, A I, Tan, Q, Yang, Z, Bolund, L, Qi, M, Yang, H, Min, J, Willcox, C D, Willcox, B, Gu, J, Hauser, E, Tian, X-L & Vaupel, J W 2016, ' Interaction between the FOXO1A-209 Genotype and Tea Drinking is Significantly Associated with Reduced Mortality at Advanced Ages ', Rejuvenation Research, vol. 19, no. 3, pp. 195-203 . https://doi.org/10.1089/rej.2015.1737

On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes and tea drinking are si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647154e0a632f3c8b69df324c55f2f72
https://pure.au.dk/portal/da/publications/interaction-between-foxo1a209-genotype-and-tea-drinking-is-significantly-associated-with-reduced-mortality-at-advanced-ages(78457f09-f0be-4255-b709-98e9e8f075fd).html