Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries

Autor: Colomer, Ignacio, Adeniji, Ololade, Burslem, George M., Craven, Philip, Rasmussen, Martin Ohsten, Willaume, Anthony, Kalliokoski, Tuomo, Foster, Richard, Marsden, Stephen P., Nelson, Adam

Publikováno v: In Bioorganic & Medicinal Chemistry 1 June 2015 23(11):2736-2740

Generation of a Heteropolycyclic and sp3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence

Autor: Flagstad, Thomas, Azevedo, Carlos M. G., Troelsen, Nikolaj S., Min, Geanna K., Macé, Yohan, Willaume, Anthony, Guilleux, Rachel, Velay, Mélanie, Bonnet, Karine, Morgentin, Remy, Nielsen, Thomas E., Clausen, Mads H.

Publikováno v: Flagstad, T, Azevedo, C M G, Troelsen, N S, Min, G K, Macé, Y, Willaume, A, Guilleux, R, Velay, M, Bonnet, K, Morgentin, R, Nielsen, T E & Clausen, M H 2019, ' Generation of a Heteropolycyclic and sp 3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence ', European Journal of Organic Chemistry, vol. 2019, no. 5, pp. 1061-1076 . https://doi.org/10.1002/ejoc.201801551
Flagstad, T, Azevedo, C, Troelsen, N S, Min, G, Macé, Y, Willaume, A, Guilleux, R, Velay, M, Bonnet, K, Morgentin, R, Nielsen, T E & Clausen, M H 2019, ' Generation of a Heteropolycyclic and Sp 3-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/DielsAlder and ROM-RCM Reaction Sequence ', European Journal of Organic Chemistry, vol. 2019, no. 5, pp. 1061-1076 . https://doi.org/10.1002/ejoc.201801551

Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::93642865fe22b10ef40d237729c570b0
https://curis.ku.dk/portal/da/publications/generation-of-a-heteropolycyclic-and-sp3rich-scaffold-for-library-synthesis-from-a-highly-diastereoselective-petasisdielsalder-and-romrcm-reaction-sequence(472ffe62-c777-4b1d-bb8c-9c609f3bbd36).html

Petasis/Diels-Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production (vol 2018, pg 5023, 2018)

Autor: Flagstad, Thomas, Azevedo, Carlos M. G., Min, Geanna, Willaume, Anthony, Morgentin, Remy, Nielsen, Thomas E., Clausen, Mads Hartvig

Publikováno v: Flagstad, T, Azevedo, C M G, Min, G, Willaume, A, Morgentin, R, Nielsen, T E & Clausen, M H 2018, ' Petasis/Diels-Alder/Cyclization Cascade Reactions for the Generation of Scaffolds with Multiple Stereogenic Centers and Orthogonal Handles for Library Production (vol 2018, pg 5023, 2018) ', European Journal of Organic Chemistry, vol. 2018, no. 46, pp. 6596-6596 . https://doi.org/10.1002/ejoc.201801730

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1202::9de15b936d9705868937ceb77af7f135
https://orbit.dtu.dk/en/publications/ef87891e-f5e0-471d-8891-fe4df4b7dab9

Generation of a Heteropolycyclic and sp³‐Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels–Alder and ROM–RCM Reaction Sequence.

Autor: Flagstad, Thomas, Azevedo, Carlos M. G., Troelsen, Nikolaj S., Min, Geanna K., Macé, Yohan, Willaume, Anthony, Guilleux, Rachel, Velay, Mélanie, Bonnet, Karine, Morgentin, Remy, Nielsen, Thomas E., Clausen, Mads H.

Publikováno v: European Journal of Organic Chemistry; 2/7/2019, Vol. 2019 Issue 5, p1061-1076, 16p