Advancements in glucagon-like peptide-1 receptor agonist therapy for type 2 diabetes.

Autor: Yaping Peng¹, Ying Fu^2,3 fuyingrlyfe@163.com

Publikováno v: Journal of Chinese Pharmaceutical Sciences. Aug2024, Vol. 33 Issue 8, p667-685. 19p.

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

Autor: Turnbull, A. P., Kimple, A. J., Siderovski, D. P., Fedorov, O. Y., Doyle, D. A., Schoch, G. A., Sundstrom, M., Ball, L. J., Hutsell, S. Q., Dowler, E. F., Willard, F. S., Higman, V. A., Soundararajan, M., Gileadi, C.

Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Gα subunits and thus facilitate termination of signaling initiated by G protein-coupled receptors (GPCRs). RGS proteins hold great promise as disease intervention points, g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d98607ec83bcacfaa01cce603290047c

Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and reduce late-stage attrition.

Autor: Kenakin T; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. kenakin@e-mail.unc.edu.

Publikováno v: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2024 Aug; Vol. 23 (8), pp. 626-644. Date of Electronic Publication: 2024 Jun 18.

Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge.

Autor: Gasbjerg LS; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rasmussen RS; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Dragan A; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lindquist P; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Melchiorsen JU; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute and Pompeu Fabra University, Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland.; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Warsaw, Poland., Schiellerup S; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tordrup EK; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gadgaard S; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Bainan Biotech, Copenhagen, Denmark., Kizilkaya HS; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Willems S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Zhong Y; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China., Wang Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, China.; National Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, China., Wright SC; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., Hartmann B; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Holst JJ; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Center for Basic Metabolic Research, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute and Pompeu Fabra University, Barcelona, Spain., Rosenkilde MM; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Jul 01. Date of Electronic Publication: 2024 Jul 01.

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