Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Will M, Lee"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to
Externí odkaz:
https://doaj.org/article/2c87f32c908144ffae74b5ab504711f7
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-3 (2017)
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
Externí odkaz:
https://doaj.org/article/b4530be0a4584214b66ef8691535f94c
Autor:
Xiang Xiao, Dolores D Mruk, Elizabeth I Tang, R'ada Massarwa, Ka Wai Mok, Nan Li, Chris K C Wong, Will M Lee, Scott B Snapper, Ben-Zion Shilo, Eyal D Schejter, C Yan Cheng
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004447 (2014)
During spermatogenesis, the blood-testis barrier (BTB) segregates the adluminal (apical) and basal compartments in the seminiferous epithelium, thereby creating a privileged adluminal environment that allows post-meiotic spermatid development to proc
Externí odkaz:
https://doaj.org/article/8b94d083f01a4d2a997accb398665ee3
Autor:
Darren S. Chu, Ren-Shan Ge, C. Yan Cheng, Qing Wen, Xiang Xiao, Will M. Lee, Bruno Silvestrini, Qingquan Lian, Wing-Yee Lui, Nan Li, Chris K C Wong
Publikováno v:
Cell Death and Disease, Vol 9, Iss 2, Pp 1-27 (2018)
Cell Death & Disease
Cell Death & Disease
Germ cell differentiation during the epithelial cycle of spermatogenesis is accompanied by extensive remodeling at the Sertoli cell–cell and Sertoli cell–spermatid interface to accommodate the transport of preleptotene spermatocytes and developin
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 314:E174-E190
The blood-testis barrier (BTB), conferred by Sertoli cells in the mammalian testis, is an important ultrastructure that supports spermatogenesis. Studies using animal models have shown that a disruption of the BTB leads to meiotic arrest, causing def
Autor:
Xiang Xiao, C. Yan Cheng, Paul J. Turek, Bruno Silvestrini, Haiqi Chen, Ying Gao, Wing-Yee Lui, Will M. Lee, Constance M. John, Dolores D. Mruk
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
PFOS induces Sertoli cell injury using testicular cells isolated from rodent testes, but it remains unknown if PFOS has similar effects in humans. Herein, we maintained human Sertoli cells in a mitotically active state in vitro, thus enabling transfe
Publikováno v:
The FASEB Journal. 31:3587-3607
Spermatogenesis takes place in the epithelium of the seminiferous tubules of the testes, producing millions of spermatozoa per day in an adult male in rodents and humans. Thus, multiple cellular events that are regulated by an array of signaling mole
Publikováno v:
The FASEB Journal. 31:584-597
Laminin α2 is one of the constituent components of the basement membrane (BM) in adult rat testes. Earlier studies that used a mouse genetic model have shown that a deletion of laminin α2 impedes male fertility by disrupting ectoplasmic specializat
Publikováno v:
Seminars in Cell & Developmental Biology. 59:62-70
When the cross-section of a seminiferous tubule from an adult rat testes is examined microscopically, Sertoli cells and germ cells in the seminiferous epithelium are notably polarized cells. For instance, Sertoli cell nuclei are found near the baseme
Publikováno v:
Seminars in Cell & Developmental Biology. 59:141-156
Sertoli cells isolated from rodents or humans and cultured in vitro are known to establish a functional tight junction (TJ)-permeability barrier that mimics the blood-testis barrier (BTB) in vivo. This model has been widely used by investigators to s