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Akademický článek

Transition from static culture to stirred tank bioreactor for the allogeneic production of therapeutic discogenic cell spheres

Autor: Daniel Rodriguez-Granrose, Jeff Zurawski, Will Heaton, Terry Tandeski, Galina Dulatov, Angelica Adrian Highsmith, Mason Conen, Garrett Clark, Amanda Jones, Hannah Loftus, Cameron LeBaron, Erin Scull, Niloo Farhang, Isaac Erickson, Justin Bingham, Paula Decaria, Nephi Jones, Kevin T. Foley, Lara Silverman

Publikováno v: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)

Abstract Background Culturing cells as cell spheres results in a tissue-like environment that drives unique cell phenotypes, making it useful for generating cell populations intended for therapeutic use. Unfortunately, common methods that utilize sta

Externí odkaz: https://doaj.org/article/b9decd5680bd4124b634eff45b1bc7c6

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Akademický článek

Perspectives on the Treatment of Lumbar Disc Degeneration: The Value Proposition for a Cell-Based Therapy, Immunomodulatory Properties of Discogenic Cells and the Associated Clinical Evaluation Strategy

Autor: Lara Ionescu Silverman, Will Heaton, Niloofar Farhang, Lindsey Hart Saxon, Galina Dulatova, Daniel Rodriguez-Granrose, Flagg Flanagan, Kevin T. Foley

Publikováno v: Frontiers in Surgery, Vol 7 (2020)

Low back pain (LBP) is a serious medical condition that affects a large percentage of the population worldwide. One cause of LBP is disc degeneration (DD), which is characterized by progressive breakdown of the disc and an inflamed disc environment.

Externí odkaz: https://doaj.org/article/4c3834f58be648aaa8f3ad142353e929

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Transition from static culture to stirred tank bioreactor for the allogeneic production of therapeutic discogenic cell spheres

Autor: Terry Tandeski, Niloo Farhang, Galina Dulatov, Isaac Erickson, Hannah Loftus, Kevin T. Foley, Garrett Clark, Angelica Adrian Highsmith, Paula Decaria, Nephi Jones, Cameron LeBaron, Justin Bingham, Daniel Rodriguez-Granrose, Mason Conen, Lara Silverman, Erin Scull, Amanda Jones, Jeff Zurawski, Will Heaton

Publikováno v: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Stem Cell Research & Therapy

BackgroundCulturing cells as cell spheres results in a tissue-like environment that drives unique cell phenotypes, making it useful for generating cell populations intended for therapeutic use. Unfortunately, common methods that utilize static suspen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993a53f9d3154b8b7b14773f9b2173cb
https://doaj.org/article/b9decd5680bd4124b634eff45b1bc7c6

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Design of experiment (DOE) applied to artificial neural network architecture enables rapid bioprocess improvement

Autor: Daniel Rodriguez-Granrose, Lara Silverman, Kevin T. Foley, Amanda Jones, Will Heaton, Hannah Loftus, Terry Tandeski

Publikováno v: Bioprocess and Biosystems Engineering

Modern bioprocess development employs statistically optimized design of experiments (DOE) and regression modeling to find optimal bioprocess set points. Using modeling software, such as JMP Pro, it is possible to leverage artificial neural networks (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fef1a3a2c1d5253aca9f5f5fcb02aee
https://doi.org/10.1007/s00449-021-02529-3

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