Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Will Eyestone"'
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89631 (2014)
As an initial step towards creating genetically modified cattle as a biopharming source of recombinant human serum albumin (rHSA), we report modification of the bovine albumin (bA) locus by transcription activator-like effector nuclease (TALEN)-stimu
Externí odkaz:
https://doaj.org/article/f8143179bfdc4acda84eb7f762c84010
Autor:
Muhammad M. Mohiuddin, Corbin E. Goerlich, Avneesh K. Singh, Tianshu Zhang, Ivan Tatarov, Billeta Lewis, Faith Sentz, Alena Hershfeld, Gheorghe Braileanu, Patrick Odonkor, Erik Strauss, Brittney Williams, Allen Burke, Jamie Hittman, Adnan Bhutta, Ali Tabatabai, Anuj Gupta, Todd Vaught, Lori Sorrells, Kasinath Kuravi, Amy Dandro, Will Eyestone, David J. Kaczorowski, David Ayares, Bartley P. Griffith
Publikováno v:
Xenotransplantation
We report orthotopic (life-supporting) survival of genetically engineered porcine cardiac xenografts (with six gene modifications) for almost 9 months in baboon recipients. This work builds on our previously reported heterotopic cardiac xenograft (th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f9e10e364453e2ea40a58a67a65d75
https://doi.org/10.1111/xen.12744
https://doi.org/10.1111/xen.12744
Autor:
Arielle Cimeno, Kasinath Kuravi, Lori Sorrells, Amy Dandro, Selin Sendil, Lars Burdorf, Dawn M. Parsell, Will Eyestone, Carol Phelps, David Ayares, Agnes M. Azimzadeh, Richard N. Pierson, Rolf N. Barth, John C. LaMattina
Publikováno v:
Xenotransplantation
INTRODUCTION: Platelet sequestration, inflammation, and inappropriate coagulation cascade activation are prominent in liver xenotransplant models and are associated with poor outcomes. Here, we evaluate a cassette of six additional genetic modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be7e88fc8c555827c271fbc6627e18
https://doi.org/10.1111/xen.12731
https://doi.org/10.1111/xen.12731
Publikováno v:
XenotransplantationREFERENCES. 28(2)
Xenotransplantation research has made considerable progress in recent years, largely through the increasing availability of pigs with multiple genetic modifications, effective immunosuppressive therapy, and anti-inflammatory therapy to protect pig ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18dcf2a7ac6627193e81552055fb97e
https://pubmed.ncbi.nlm.nih.gov/33058285
https://pubmed.ncbi.nlm.nih.gov/33058285
Autor:
Huy Q Nguyen, David K. C. Cooper, Will Eyestone, Hayato Iwase, Jeremy B. Foote, David Ayares, Yuko Miyagawa, Hidetaka Hara, Kasinath Kuravi, Carol Phelps
Publikováno v:
Cytokine
Background Xenotransplantation is associated with an inflammatory response. The proinflammatory cytokine, TNF-α, downregulates the expression of thrombomodulin (TBM), and induces coagulation dysfunction. Although human (h) TBM-transgenic pigs (p) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a685307ac5639f0c4a6663325f6b9a54
https://doi.org/10.1016/j.cyto.2021.155580
https://doi.org/10.1016/j.cyto.2021.155580
Autor:
Richard N. Pierson, Margaret R. Connolly, Will Eyestone, Kaitlyn Petitpas, Carol Phelps, David Ayares, Agnes Azimzadeh, Xiangfei Cheng, Christopher Laird, Shannon Pratts, Benjamin Cerel, Zahra Abady, Lars Burdorf
Publikováno v:
Transplantation. 104:S637-S638
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dae3eff80cbe03d5e5b5d4ce07c327a0
https://doi.org/10.1097/01.tp.0000702048.27263.77
https://doi.org/10.1097/01.tp.0000702048.27263.77
Autor:
Richard N. Pierson, David Ayares, C. Phelps, Kaitlyn Petitpas, Xiangfei Cheng, Christopher Laird, Margaret R. Connolly, Shannon Pratts, Benjamin Cerel, Agnes Azimzadeh, Will Eyestone, Zahra Alikhassy Habibabady, Lars Burdorf
Publikováno v:
The Journal of Heart and Lung Transplantation. 40:S51
Purpose Antibody-mediated xenograft rejection is inhibited by knock-out (KO) of porcine carbohydrates (CHO), including Galα1,3Gal. The β4Gal epitope was discovered using serum from xenograft-sensitized baboons. However, it remains controversial if
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c371ffbc8ccf5c7b6f76d9b285b8787
https://doi.org/10.1016/j.healun.2021.01.1865
https://doi.org/10.1016/j.healun.2021.01.1865
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e89631 (2014)
PLoS ONE, Vol 9, Iss 2, p e89631 (2014)
As an initial step towards creating genetically modified cattle as a biopharming source of recombinant human serum albumin (rHSA), we report modification of the bovine albumin (bA) locus by transcription activator-like effector nuclease (TALEN)-stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5feb20eb20dcf5d2b7f9f28e7c6db1ee
https://pubmed.ncbi.nlm.nih.gov/24586924
https://pubmed.ncbi.nlm.nih.gov/24586924
Autor:
Paul Krimpenfort, Adriana Rademakers, Will Eyestone, Adriaan van der Schans, Sandra van den Broek, Patricia Kooiman, Erika Kootwijk, Gerard Platenburg, Frank Pieper, Rein Strijker, Herman de Boer
Publikováno v:
Nature Biotechnology. 9:844-847
We have combined gene transfer, by microinjection, with 'in vitro' embryo production technology, enabling us to carry out non-surgical transfer, to recipient cows, of microinjected embryos that have been cultured from immature oocytes. Using this app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8d7bf9e882f9c8947d69f82af452f
https://doi.org/10.1038/nbt0991-844
https://doi.org/10.1038/nbt0991-844
Autor:
Oscar Peralta, Will Eyestone
Publikováno v:
Biology of Reproduction. 77:193-194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d066fcbe535bda5c13bcdc3fe84046f2
https://doi.org/10.1093/biolreprod/77.s1.193b
https://doi.org/10.1093/biolreprod/77.s1.193b