Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms

Autor: Will Duke, Rebecca J. Oakey, Reiner Schulz, Bertille Montibus, Ann Mullally, Ferdinand von Meyenn, Donal P. McLornan, Azucena Rocha, Claire N. Harrison, Stephania Contreras Castillo

Publikováno v: Genome Research, 31 (8)
Genome Res
Castillo, S C, Montibus, B, Rocha, A, Duke, W, von Meyenn, F, McLornan, D, Harrison, C, Mullally, A, Schulz, R & Oakey, R J 2021, ' Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms ', Genome Research, vol. 31, no. 8, pp. 1381-1394 . https://doi.org/10.1101/gr.270066.120

Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA methylation. Ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1a360a9e920af7bb170220cdf8fb20
https://hdl.handle.net/20.500.11850/501218