DNA binding and bridging by human CtIP in the healthy and diseased states.

Autor: Lokanathan Balaji S; DNA:Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., De Bragança S; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, 28049, Spain., Balaguer-Pérez F; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, 28049, Spain., Northall S; DNA:Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., Wilkinson OJ; DNA:Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK., Aicart-Ramos C; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, 28049, Spain., Seetaloo N; Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Sobott F; Astbury Centre for Structural Molecular Biology and School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Moreno-Herrero F; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, 28049, Spain., Dillingham MS; DNA:Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Aug 12; Vol. 52 (14), pp. 8303-8319.

Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub.

Autor: Wilkinson M; Section of Structural Biology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom., Wilkinson OJ; DNA:protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol, United Kingdom., Feyerherm C; DNA:protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol, United Kingdom., Fletcher EE; DNA:protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol, United Kingdom., Wigley DB; Section of Structural Biology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom., Dillingham MS; DNA:protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol, United Kingdom.

Publikováno v: ELife [Elife] 2022 Dec 19; Vol. 11. Date of Electronic Publication: 2022 Dec 19.

Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae .

Autor: Stevens EJ; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Morse DJ; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Bonini D; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Duggan S; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Brignoli T; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK., Recker M; Centre for Ecology and Conservation, University of Exeter, Penryn Campus, Exeter, TR10 9FE, UK.; Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany., Lees JA; MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, W2 1PG, UK., Croucher NJ; MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, St. Mary's Campus, Imperial College London, London, W2 1PG, UK., Bentley S; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Wilson DJ; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Earle SG; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Dixon R; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Nobbs A; Bristol Dental School, University of Bristol, Bristol, BS1 2LY, UK., Jenkinson H; Bristol Dental School, University of Bristol, Bristol, BS1 2LY, UK., van Opijnen T; Biology Department, Boston College, Chestnut Hill, MA, USA., Thibault D; Biology Department, Boston College, Chestnut Hill, MA, USA., Wilkinson OJ; DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Dillingham MS; DNA-Protein Interactions Unit, School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK., Carlile S; Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., McLoughlin RM; Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Massey RC; School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK.; Schools of Microbiology and Medicine and APC Microbiome Ireland, University College Cork, Cork, Ireland.

Publikováno v: Microbial genomics [Microb Genom] 2022 Apr; Vol. 8 (4).

A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection.

Autor: Kuster A; Institute of Molecular Cancer Research, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland., Mozaffari NL; Institute of Molecular Cancer Research, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland., Wilkinson OJ; School of Biochemistry, University of Bristol, University Walk, Clifton BS8 1TD, Bristol, UK., Wojtaszek JL; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, U.S. National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Zurfluh C; Institute of Molecular Cancer Research, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland., Przetocka S; Institute of Molecular Cancer Research, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland., Zyla D; Institute of Molecular Biology and Biophysics, ETH-Zürich, Otto-Stern-Weg 5, CH-8093 Zürich, Switzerland., von Aesch C; Institute of Molecular Cancer Research, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland., Dillingham MS; School of Biochemistry, University of Bristol, University Walk, Clifton BS8 1TD, Bristol, UK., Williams RS; Structural Cell Biology Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, U.S. National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Sartori AA; Institute of Molecular Cancer Research, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. sartori@imcr.uzh.ch.

Publikováno v: Science advances [Sci Adv] 2021 Feb 19; Vol. 7 (8). Date of Electronic Publication: 2021 Feb 19 (Print Publication: 2021).

Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O ⁶ -methylguanine and their recognition by MGMT and Atl1.

Autor: Abdu K; Department of Pure and Industrial Chemistry, Faculty of Physical Sciences, Bayero University, Kano, Nigeria., Aiertza MK; Centre for Chemical Biology, Department of Chemistry, Sheffield Institute for Nucleic Acids, University of Sheffield, Sheffield, UK., Wilkinson OJ; Centre for Chemical Biology, Department of Chemistry, Sheffield Institute for Nucleic Acids, University of Sheffield, Sheffield, UK., Senthong P; Centre of Epidemiology, Faculty of Biology, Medicine and Health., Craggs TD; Centre for Chemical Biology, Department of Chemistry, Sheffield Institute for Nucleic Acids, University of Sheffield, Sheffield, UK., Povey AC; Centre of Epidemiology, Faculty of Biology, Medicine and Health., Margison GP; Centre of Epidemiology, Faculty of Biology, Medicine and Health., Williams DM; Centre for Chemical Biology, Department of Chemistry, Sheffield Institute for Nucleic Acids, University of Sheffield, Sheffield, UK.

Publikováno v: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2020; Vol. 39 (8), pp. 1108-1121. Date of Electronic Publication: 2020 May 23.