When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions.

Autor: Bradbury ARM; a Specifica Inc. , 1512 Pacheco St, Santa Fe , NM , USA., Trinklein ND; b SwitchGear Genomics , 1914 Palomar Oaks Way, Carlsbad , CA USA., Thie H; c Miltenyi Biotec GmbH , Friedrich-Ebert-Str. 68, Bergisch Gladbach , Germany., Wilkinson IC; d Absolute Antibody, Wilton Centre , Redcar , Cleveland TS10 4RF , United Kingdom., Tandon AK; e NeoBiotechnologies , 2 Union Square, Union City , CA , USA., Anderson S; d Absolute Antibody, Wilton Centre , Redcar , Cleveland TS10 4RF , United Kingdom., Bladen CL; d Absolute Antibody, Wilton Centre , Redcar , Cleveland TS10 4RF , United Kingdom., Jones B; e NeoBiotechnologies , 2 Union Square, Union City , CA , USA., Aldred SF; b SwitchGear Genomics , 1914 Palomar Oaks Way, Carlsbad , CA USA., Bestagno M; f International Centre for Genetic Engineering and Biotechnology (ICGEB) , Padriciano 99, Trieste , Italy., Burrone O; f International Centre for Genetic Engineering and Biotechnology (ICGEB) , Padriciano 99, Trieste , Italy., Maynard J; g The University of Texas at Austin, Cockrell School of Engineering , McKetta Department of Chemical Engineering , 200 E Dean Keeton St. Stop C0400, Austin , Texas , USA., Ferrara F; a Specifica Inc. , 1512 Pacheco St, Santa Fe , NM , USA., Trimmer JS; h Department of Physiology and Membrane Biology , University of California , Davis, One Shields Avenue, Davis , CA , USA., Görnemann J; i Institute for Molecular Genetics , University of Heidelberg , Im Neuenheimer Field 260, Heidelberg , Germany., Glanville J; j Stanford University, School of Medicine , Stanford , California , USA., Wolf P; k Department of Urology , Medical Center, University of Freiburg , Breisacher Str. 66, Freiburg , Germany., Frenzel A; l Yumab GmbH , Inhoffenstr. 7, Braunschweig , Germany.; p Technische Universität Braunschweig, Institute of Biochemistry, Biotechnology and Bioinformatics , Spielmannstr. 7, Braunschweig , Germany., Wong J; m A*Star p53 laboratory , 06-06 Immunos, Singapore , Singapore., Koh XY; m A*Star p53 laboratory , 06-06 Immunos, Singapore , Singapore., Eng HY; m A*Star p53 laboratory , 06-06 Immunos, Singapore , Singapore., Lane D; m A*Star p53 laboratory , 06-06 Immunos, Singapore , Singapore., Lefranc MP; n IMGT®, the international ImMunoGeneTics information system®, Laboratoire d'ImmunoGénétique Moléculaire LIGM, Institut de Génétique Humaine IGH, UPR CNRS 1142, Montpellier University , Montpellier cedex 5 , France., Clark M; o Clark Antibodies Ltd , 10 Wellington Street, Cambridge , CB1 1HW , United Kingdom., Dübel S; p Technische Universität Braunschweig, Institute of Biochemistry, Biotechnology and Bioinformatics , Spielmannstr. 7, Braunschweig , Germany.

Publikováno v: MAbs [MAbs] 2018 May/Jun; Vol. 10 (4), pp. 539-546. Date of Electronic Publication: 2018 Mar 29.

Monovalent IgG4 molecules: immunoglobulin Fc mutations that result in a monomeric structure.

Autor: Wilkinson IC; MedImmune Ltd.; Department of Antibody Discovery and Protein Engineering; Cambridge, UK., Fowler SB; MedImmune Ltd.; Department of Antibody Discovery and Protein Engineering; Cambridge, UK., Machiesky L; MedImmune LLC.; Departments of Antibody Discovery and Protein Engineering and Analytical Biochemistry; Gaithersburg, MD USA., Miller K; MedImmune LLC.; Departments of Antibody Discovery and Protein Engineering and Analytical Biochemistry; Gaithersburg, MD USA., Hayes DB; MedImmune LLC.; Departments of Antibody Discovery and Protein Engineering and Analytical Biochemistry; Gaithersburg, MD USA., Adib M; MedImmune LLC.; Departments of Antibody Discovery and Protein Engineering and Analytical Biochemistry; Gaithersburg, MD USA., Her C; MedImmune LLC.; Departments of Antibody Discovery and Protein Engineering and Analytical Biochemistry; Gaithersburg, MD USA., Borrok MJ; MedImmune LLC.; Departments of Antibody Discovery and Protein Engineering and Analytical Biochemistry; Gaithersburg, MD USA., Tsui P; MedImmune LLC.; Departments of Antibody Discovery and Protein Engineering and Analytical Biochemistry; Gaithersburg, MD USA., Burrell M; MedImmune Ltd.; Department of Antibody Discovery and Protein Engineering; Cambridge, UK., Corkill DJ; MedImmune Ltd.; Department of Antibody Discovery and Protein Engineering; Cambridge, UK., Witt S; MedImmune Ltd.; Department of Antibody Discovery and Protein Engineering; Cambridge, UK., Lowe DC; MedImmune Ltd.; Department of Antibody Discovery and Protein Engineering; Cambridge, UK., Webster CI; MedImmune Ltd.; Department of Antibody Discovery and Protein Engineering; Cambridge, UK.

Publikováno v: MAbs [MAbs] 2013 May-Jun; Vol. 5 (3), pp. 406-17. Date of Electronic Publication: 2013 Apr 08.