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Whole genome profiling of rare pediatric thoracic tumors elucidates a YAP1::LEUTX fusion in an unclassified biphasic embryonal neoplasm.

Autor: Lukose G; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Al Assaad M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Driskill JH; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Levine MF; Isabl Inc., New York, NY, USA., Gundem G; Isabl Inc., New York, NY, USA., Semaan A; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Wilkes DC; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Spigland NA; Department of Surgery, Division of Pediatric Surgery, Weill Cornell Medicine / NewYork-Presbyterian Hospital, New York, NY, USA., Medina-Martínez JS; Isabl Inc., New York, NY, USA., Sboner A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Elemento O; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Jessurun J; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Mosquera JM; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA. Electronic address: jmm9018@med.cornell.edu.

Publikováno v: Pathology, research and practice [Pathol Res Pract] 2024 Dec; Vol. 264, pp. 155726. Date of Electronic Publication: 2024 Nov 19.

Optimization of Fluorescence In Situ Hybridization Protocols in the Era of Precision Medicine.

Autor: Kudman S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Semaan A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Assaad MA; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Gogineni S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Martin ML; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Mathew S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Elemento O; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, New York., Wilkes DC; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York., Mosquera JM; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.

Publikováno v: Current protocols [Curr Protoc] 2024 Jun; Vol. 4 (6), pp. e1093.

Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer.

Autor: Raman R; Department of Surgery, Weill Cornell Medical College, New York, NY., Villefranc JA; Department of Surgery, Weill Cornell Medical College, New York, NY., Ullmann TM; Department of Surgery, Weill Cornell Medical College, New York, NY., Thiesmeyer J; Department of Surgery, Weill Cornell Medical College, New York, NY., Anelli V; Department of Surgery, Weill Cornell Medical College, New York, NY., Yao J; Department of Surgery, Weill Cornell Medical College, New York, NY., Hurley JR; Department of Medicine, Weill Cornell Medical College, New York, NY., Pauli C; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Bareja R; The Caryl and Israel Englander Institute for Precision Medicine and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY., Wha Eng K; The Caryl and Israel Englander Institute for Precision Medicine and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY., Dorsaint P; The Caryl and Israel Englander Institute for Precision Medicine and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY., Wilkes DC; The Caryl and Israel Englander Institute for Precision Medicine and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY., Beg S; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Kudman S; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Shaw R; SEngine Precision Medicine, Seattle, WA., Churchill M; SEngine Precision Medicine, Seattle, WA., Ahmed A; Department of Biochemistry, Weill Cornell Medical College, New York, NY., Keefer L; Personal Genome Diagnostics, Inc., Baltimore, MD., Misner I; Personal Genome Diagnostics, Inc., Baltimore, MD., Nichol D; Personal Genome Diagnostics, Inc., Baltimore, MD., Gumpeni N; Department of Radiology, Weill Cornell Medical College, New York, NY., Scognamiglio T; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Rubin MA; Bern Center for Precision Medicine, University of Bern, Bern, Switzerland., Grandori C; SEngine Precision Medicine, Seattle, WA., Solomon JP; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Song W; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Mosquera JM; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Dephoure N; Department of Biochemistry, Weill Cornell Medical College, New York, NY.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY., Sboner A; The Caryl and Israel Englander Institute for Precision Medicine and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY.; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY., Elemento O; The Caryl and Israel Englander Institute for Precision Medicine and the Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY., Houvras Y; Department of Surgery, Weill Cornell Medical College, New York, NY.; Department of Medicine, Weill Cornell Medical College, New York, NY.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College, New York, NY.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2022 Jun 06; Vol. 219 (6). Date of Electronic Publication: 2022 May 05.

Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia.

Autor: Sugita M; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA., Wilkes DC; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Bareja R; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Eng KW; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Nataraj S; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA., Jimenez-Flores RA; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA., Yan L; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA., De Leon JP; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA., Croyle JA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Kaner J; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA., Merugu S; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sharma S; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., MacDonald TY; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Noorzad Z; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Panchal P; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pancirer D; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Cheng S; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Xiang JZ; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Olson L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Van Besien K; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Rickman DS; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Mathew S; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Tam W; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Rubin MA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Bern Center of Precision Medicine, Universität of Bern, Bern, Switzerland., Beltran H; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Sboner A; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Hassane DC; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA., Chiosis G; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Elemento O; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Roboz GJ; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA., Mosquera JM; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA. jmm9018@med.cornell.edu.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. jmm9018@med.cornell.edu., Guzman ML; Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA. mlg2007@med.cornell.edu.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine and NewYork Presbyterian, New York, NY, USA. mlg2007@med.cornell.edu.; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA. mlg2007@med.cornell.edu.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2021 May 26; Vol. 5 (1), pp. 44. Date of Electronic Publication: 2021 May 26.