The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α 2 receptor activity in vitro and in vivo.

Autor: Obeng S; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Crowley ML; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Mottinelli M; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., León F; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Zuarth Gonzalez JD; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Chen Y; Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Atlanta, GA, 30341, USA., Gamez-Jimenez LR; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Restrepo LF; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Ho NP; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Patel A; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Martins Rocha J; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Alvarez MA; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Thadisetti AM; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Park CR; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Pallares VLC; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Milner MJ; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Canal CE; Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Atlanta, GA, 30341, USA., Hampson AJ; Division of Therapeutics and Medical Consequences, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, 20892, USA., McCurdy CR; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA; Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA; Translational Drug Development Core, Clinical and Translational Sciences Institute, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., McMahon LR; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA., Wilkerson JL; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA. Electronic address: Jenny.Wilkerson@ttuhsc.edu., Hiranita T; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA. Electronic address: hiranita@uthscsa.edu.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2024 Oct 05; Vol. 980, pp. 176863. Date of Electronic Publication: 2024 Jul 26.

Characterization of commercially available murine fibrosarcoma NCTC-2472 cells both in vitro and as a model of bone cancer pain in vivo.

Autor: Ortiz YT; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, United States of America.; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America., Shamir LG; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America., McMahon LR; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America., Wilkerson JL; Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America.

Publikováno v: PloS one [PLoS One] 2024 Aug 29; Vol. 19 (8), pp. e0309398. Date of Electronic Publication: 2024 Aug 29 (Print Publication: 2024).

Ceramides are fuel gauges on the drive to cardiometabolic disease.

Autor: Wilkerson JL; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States., Tatum SM; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States., Holland WL; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States., Summers SA; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States.

Publikováno v: Physiological reviews [Physiol Rev] 2024 Jul 01; Vol. 104 (3), pp. 1061-1119. Date of Electronic Publication: 2024 Feb 01.

Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics.

Autor: Frimpong-Manson K; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, United States., Ortiz YT; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, United States., McMahon LR; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, United States., Wilkerson JL; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, United States.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2024 Feb 28; Vol. 17, pp. 1355281. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024).

Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk.

Autor: Li Y; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Chaurasia B; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah; Division of Endocrinology, Department of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa. Electronic address: bhagirath-chaurasia@uiowa.edu., Rahman MM; Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah., Kaddai V; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Maschek JA; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Berg JA; Department of Biochemistry, University of Utah, Salt Lake City, Utah., Wilkerson JL; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Mahmassani ZS; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah., Cox J; Department of Biochemistry, University of Utah, Salt Lake City, Utah., Wei P; Department of Biochemistry, University of Utah, Salt Lake City, Utah., Meikle PJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Atkinson D; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Wang L; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Poss AM; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Playdon MC; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Tippetts TS; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Mousa EM; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah; Faculty of Science, Tanta University, Tanta, Egypt., Nittayaboon K; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah; Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand., Anandh Babu PV; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Drummond MJ; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands; Oncode Institute, Utrecht, The Netherlands; Princess Maxima Center (PMC) for Pediatric Oncology, Utrecht, The Netherlands., Shayman JA; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan., Hirabayashi Y; Cellular Informatics Laboratory, RIKEN Cluster for Pioneering Research, RIKEN, Wako-shi, Saitama Japan., Holland WL; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah., Rutter J; Department of Biochemistry, University of Utah, Salt Lake City, Utah; Howard Hughes Medical Institute, Salt Lake City, Utah., Edgar BA; Huntsman Cancer Institute and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah., Summers SA; Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center, University of Utah, Salt Lake City, Utah. Electronic address: scott.a.summers@health.utah.edu.

Publikováno v: Gastroenterology [Gastroenterology] 2023 Nov; Vol. 165 (5), pp. 1136-1150. Date of Electronic Publication: 2023 Aug 02.