Enhancing radiotherapy response via intratumoral injection of the TLR9 agonist CpG to stimulate CD8 T cells in an autochthonous mouse model of sarcoma.

Autor: Su C; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Kent CL; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Pierpoint M; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Floyd W; MD Anderson Cancer Center, Houston, TX, USA., Luo L; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Wiliams NT; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Ma Y; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Peng B; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Lazarides AL; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Subramanian A; Department of Radiation Oncology, Stanford University, Stanford, CA, USA., Himes JE; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Perez VM; Tempus AI, Inc., Durham, NC, USA., Hernansaiz-Ballesteros RD; Tempus AI, Inc., Durham, NC, USA., Roche KE; Tempus AI, Inc., Durham, NC, USA.; QuantBio, LLC., Durham, NC, USA., Modliszewski JL; QuantBio, LLC., Durham, NC, USA., Selitsky SR; Tempus AI, Inc., Durham, NC, USA.; QuantBio, LLC., Durham, NC, USA., Mari Shinohara; Department of Immunology, Duke University, Durham, NC, USA., Wisdom AJ; Department of Radiation Oncology, Harvard University, Cambridge, MA, USA., Moding EJ; Stanford Cancer Institute, Stanford University, Stanford, CA, USA.; Department of Radiation Oncology, Stanford University, Stanford, CA, USA., Mowery YM; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.; MD Anderson Cancer Center, Houston, TX, USA.; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA., Kirsch DG; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 04. Date of Electronic Publication: 2024 Jan 04.