Výsledky vyhledávání - "Wilhelmus H. J. Boesten"

Resolution of (RS)-phenylglycinonitrile by penicillin acylase-catalyzed acylation in aqueous medium

Autor: Vytas K. Švedas, Wilhelmus H. J. Boesten, Ghermes G. Chilov, Harold Monro Moody

Publikováno v: Tetrahedron: Asymmetry. 14:2613-2617

A new strategy for the biocatalytic resolution of (R,S)-phenylglycinonitrile, a crucial intermediate in the antibiotic industry, has been developed. While former techniques exploit nitrilases or combinations of nitrile hydratases and amidases, manipu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34b28b8ac09883e295c46861b3db5cdd
https://doi.org/10.1016/s0957-4166(03)00523-8

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Synthesis of Enantiomerically Pure Cyclohexylglycine

Autor: Wilhelmus H. J. Boesten, Hubertus Josephus Marie Zeegers, Adriaan J. Minnaard

Publikováno v: Synthetic Communications, 29(24), 4327-4332. Marcel Dekker

(S)-cyclohexylglycine (1) is prepared in high yield by hydrogenation of (S)-phenylglycine (2) using rhodium on carbon as the catalyst.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff57695c4c37c01a13d39eca333e271
https://doi.org/10.1080/00397919908086593

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Synthesis of 4-Sulfur-Substituted (2S,3R)-3-Phenylserines by Enzymatic Resolution. Enantiopure Precursors for Thiamphenicol and Florfenicol

Autor: Bernard Kaptein, Wilhelmus H. J. Boesten, and Quirinus B. Broxterman, Alexander L. L. Duchateau, Thei J. G. M. van Dooren, Theo Sonke, Johan Kamphuis

Publikováno v: Organic Process Research & Development. 2:10-17

Enantiomerically pure 4-methylthio- and 4-methylsulfonyl-substituted (2S,3R)-3-phenylserines are prepared by enzymatic resolution of the corresponding racemic threo amides using the amidase from Ochrobactrum anthropi NCIMB 40321. The unwanted (2R,3S)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4edcf844c4add73c8da94f85e486f272
https://doi.org/10.1021/op970045t

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Aspartame dipeptide analogues: effect of number of side-chain methylene group spacers and Cα-methylation in the second position

Autor: Quirinus B. Broxterman, Wilhelmus H. J. Boesten, Peter J. L. M. Quaedflieg, Fernando Formaggio, Marco Crisma, Piero Andrea Temussi, Claudio Toniolo, Eric Mossel, Johan Kamphuis

Publikováno v: Tetrahedron: Asymmetry. 8:1305-1314

Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartame analogues in which the L-Phe 2 residue is replaced by L-(αMe)Phg, L-(αMe)Phe or L-(αMe)Hph. The analogues containing either the first or the thir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0498a1e44792fe1668bb97c4a0a347e7
https://doi.org/10.1016/s0957-4166(97)00127-4

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Synthesis of enantiomerically pure 2,2-disubstituted-2-amino-ethanols by dissolving metal reduction of a,a-disubstituted amino acid amides

Autor: Quirinus B. Broxterman, Bernard Kaptein, Harold Monro Moody, Johan Kamphuis, Wilhelmus H. J. Boesten

Publikováno v: Tetrahedron Letters. 35:1777-1780

Enantiomerically pure 2,2-disubstituted 2-amino-ethanols are prepared in 65 – 99% yield by reduction of a , a -disubstituted amino acid amides using liquid sodium metal in refluxing 1-propanol.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bfa44e7ca333fa439ce5c1ee7f593e2
https://doi.org/10.1016/0040-4039(94)88344-0

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Position of side-chain branching and handedness of turns and helices of homopeptides from chiral Cα-methylated amino acids. Crystal-state structural analysis of (αMe)Leu trimer and tetramer

Autor: Wilhelmus H. J. Boesten, Daniel Bayeul, André Aubry, Gilles Precigoux, Marco Crisma, Hans E. Schoemaker, Johan Kamphuis, Claudio Toniolo, Fernando Formaggio, M. Pantano

Publikováno v: J. Chem. Soc., Perkin Trans. 2. :525-529

Terminally blocked homotri- and homotetra-peptides from (αMe)Leu, a chiral Cα-methylated, γ-branched α-amino acid, have been prepared by solution methods and fully characterized. The molecular and crystal structures of pBrBz-[D-(αMe)Leu]3-OH mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda519800e47f77845090f967edf3d4b
https://doi.org/10.1039/p29940000525

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Structural versatility of peptides from Cα, α-disubstituted glycines: Crystal-state conformational analysis of homopeptides from Cα-methyl, Cα-benzylglycine [(αMe)Phe]n

Autor: Wilhelmus H. J. Boesten, Gilles Precigoux, Johan Kamphuis, Quirinus B. Broxterman, Gerlind Sulzenbacher, Giovanni Valle, Claudio Toniolo, Hans E. Schoemaker, Fernando Formaggio, M. Pantano, Marco Crisma

Publikováno v: Biopolymers. 33:1617-1625

The molecular and crystal structures of one derivative and three homopeptides (from the di-to the tetrapeptide level) of the chiral, Cα, α-disubstituted glycine Cα-methyl, Cα-benzylglycine [(αMe)Phe], have been determined by x-ray diffraction. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55f7c552504c00391914ffbebccae335
https://doi.org/10.1002/bip.360331011

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Enzymatic resolution of α,α-disubstituted α-amino acid esters and amides

Autor: Quirinus B. Broxterman, Wilhelmus H. J. Boesten, Bernard Kaptein, P. J. H. Peters, Hans E. Schoemaker, Johan Kamphuis

Publikováno v: Tetrahedron: Asymmetry. 4:1113-1116

The scope and limitations of the enzymatic resolution of α,α-disubstituted α-amino acid amides by an amino acid amidase from Mycobacterium neoaurum and of the corresponding ethyl esteis with Pig liver estetase (PLE) have been studied. Moderate ena

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::244b0569ae83bd88b9cbd82e04c2bd45
https://doi.org/10.1016/s0957-4166(00)80217-7

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