Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice

Autor: Krishnakumar Kizhatil, Danilo G. Macalinao, Sally H. Cross, Wilhelmine N. de Vries, Ian J. Jackson, K. Saidas Nair, Nicholas G. Tolman, Alison L. Kearney, Christa L. Montgomery, Katharine H. MacNicoll, Revathi Balasubramanian, Simon W. M. John

Publikováno v: Tolman, NG, Balasubramanian, R, Macalinao, D G, Kearney, A L, MacNicoll, KH, Montgomery, C L, de Vries, WN, Jackson, I J, Cross, S, Kizhatil, K, Nair, KS & John, SWM 2021, ' Genetic background modifies vulnerability to glaucoma related phenotypes in Lmx1b mutant mice ', Disease Models and Mechanisms . https://doi.org/10.1242/dmm.046953
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)

Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75d0cad79578c4d4f4a32c26eefdf6
https://doi.org/10.1242/dmm.046953

Mutations in a P-type ATPase gene cause axonal degeneration.

Autor: Xianjun Zhu, Richard T Libby, Wilhelmine N de Vries, Richard S Smith, Dana L Wright, Roderick T Bronson, Kevin L Seburn, Simon W M John

Publikováno v: PLoS Genetics, Vol 8, Iss 8, p e1002853 (2012)

Neuronal loss and axonal degeneration are important pathological features of many neurodegenerative diseases. The molecular mechanisms underlying the majority of axonal degeneration conditions remain unknown. To better understand axonal degeneration,

Externí odkaz: https://doaj.org/article/da26f2d8ea6b4c77b3012226bd4e99c5

Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease

Autor: Simon W. M. John, Wilhelmine N. de Vries, Leah C. Graham, Ileana Soto, Gareth R. Howell, Jeffrey M. Harder

Publikováno v: Scientific Reports

Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer’s disease (AD). Therefore, we have formulated the first western-style diet that mimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74253487b2f54ce863acffc17d3d46bd
https://doi.org/10.1038/srep21568

Polymer-based miniature flexible capacitive pressure sensor for intraocular pressure (IOP) monitoring inside a mouse eye

Autor: Pedro P. Irazoqui, Simon W. M. John, Wilhelmine N. de Vries, Dohyuk Ha, William J. Chappell

Publikováno v: Biomedical Microdevices. 14:207-215

This paper presents an ultra-thin and flexible polymer-based capacitive pressure sensor for intraocular pressure (IOP) monitoring in a mouse eye. Due to the size limitation of the anterior chamber in the mouse eye, a volume of approximately 700 × 70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a4015bb0ef50bb9e2fc736757c8fd4
https://doi.org/10.1007/s10544-011-9598-3

Stabilization of β-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast

Autor: Stefan Kuppig, Kati Hansen, Rolf Kemler, Makoto Mark Taketo, Barbara B. Knowles, Davor Solter, Benoît Kanzler, Wilhelmine N. de Vries, Andreas Hierholzer

Publikováno v: Development. 131:5817-5824

Many components of the Wnt/beta-catenin signaling pathway are expressed during mouse pre-implantation embryo development, suggesting that this pathway may control cell proliferation and differentiation at this time. We find no evidence for a function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00a3552d3b908ddc442e3c1cc7665ae
https://doi.org/10.1242/dev.01458