Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Wilhelmiina Niininen"'
Autor:
Juuli Raivola, Alice Dini, Hanna Karvonen, Emilia Piki, Kari Salokas, Wilhelmiina Niininen, Laura Kaleva, Kaiyang Zhang, Mariliina Arjama, Greta Gudoityte, Brinton Seashore-Ludlow, Markku Varjosalo, Olli Kallioniemi, Sampsa Hautaniemi, Astrid Murumägi, Daniela Ungureanu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-12 (2022)
Abstract Most patients with ovarian cancer (OC) are diagnosed at a late stage when there are very few therapeutic options and a poor prognosis. This is due to the lack of clearly defined underlying mechanisms or an oncogenic addiction that can be tar
Externí odkaz:
https://doaj.org/article/47baa86ead214039b8cd980a88935c5f
Autor:
Hanna Karvonen, David Chiron, Wilhelmiina Niininen, Sara Ek, Mats Jerkeman, Elaheh Moradi, Matti Nykter, Caroline A. Heckman, Olli Kallioniemi, Astrid Murumägi, Daniela Ungureanu
Publikováno v:
Blood Advances, Vol 1, Iss 24, Pp 2257-2268 (2017)
Abstract: Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin B-cell lymphoma with poor prognosis due to drug resistance. Introduction of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib has markedly improved MCL therapy outcome, but
Externí odkaz:
https://doaj.org/article/92dd92c16c3d495f9a8b7534d99e69a8
Publikováno v:
Cells, Vol 8, Iss 8, p 812 (2019)
Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial−mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly l
Externí odkaz:
https://doaj.org/article/fe778c0fea734881ad89d78a75f9ade8
Autor:
Juuli Raivola, Alice Dini, Kari Salokas, Hanna Karvonen, Wilhelmiina Niininen, Emilia Piki, Markku Varjosalo, Daniela Ungureanu
ROR1, ROR2, and PTK7 are Wnt ligand-binding members of the receptor tyrosine kinase family. Despite their lack of catalytic activity, these receptors regulate skeletal, cardiorespiratory, and neurological development during embryonic and fetal stages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dd1d985a5fb13438693e4978bc089b
https://trepo.tuni.fi/handle/10024/141254
https://trepo.tuni.fi/handle/10024/141254
Autor:
Stefan Knapp, Deep Chatterjee, Daniela Ungureanu, Ravi Radhakrishnan, Yuko Tsutsui, Robert Perttilä, Franziska Preuss, Ketan Malhotra, Wilhelmiina Niininen, Steven Stayrook, Krishna Suresh, Joshua B. Sheetz, Sebastian Mathea, Hanna Karvonen, Mark A. Lemmon
Publikováno v:
Mol Cell
Despite their apparent lack of catalytic activity, pseudokinases are essential signaling molecules. Here, we describe the structural and dynamic properties of pseudokinase domains from the Wnt-binding receptor tyrosine kinases (PTK7, ROR1, ROR2, and
Autor:
Daniela Ungureanu, Caroline A. Heckman, Astrid Murumägi, Harlan Barker, Veera Hautanen, Hanna Karvonen, Robert Perttilä, Wilhelmiina Niininen
Publikováno v:
Oncogene. 38:3288-3300
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with TCF3-PBX1 fusion gene expression has constitutively elevated levels of Wnt16b and ROR1 (receptor tyrosine kinase-like orphan receptor), a ligand and a receptor from the Wnt signaling pathwa
Autor:
Daniela Ungureanu, Johanna Mäenpää, Tapio Visakorpi, K Veskimäe, Hanna Karvonen, S Jaatinen, Wilhelmiina Niininen, Synnöve Staff, Mauro Scaravilli, Matti Nykter
Publikováno v:
Translational Oncology, Vol 11, Iss 5, Pp 1160-1170 (2018)
Ovarian cancer has the highest mortality rate of all gynecologic malignancies. Identification of new biomarkers is highly needed due to its late diagnosis and high recurrence rate. The objective of this study was to identify mechanisms of therapy res
Publikováno v:
FEBS Letters. 592:434-445
The ROR family of receptor tyrosine kinases, ROR1 and ROR2, is known to play an important role during skeletal muscle regeneration. ROR1 has a critical role in regulating satellite cell (SC) proliferation during muscle regeneration, and proinflammato
Publikováno v:
Biochemical Society Transactions. 45:457-464
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR receptor family consisting of two closely related type I transmembrane proteins ROR1 and ROR2. Owing to mutations in their canonical motifs required for proper kinase activ
Autor:
Marko Pesu, Ville Kytölä, Anna Grönholm, Saara Aittomäki, Antti Ylipää, Wilhelmiina Niininen, Zuzet Martinez Cordova, Ilkka Junttila, Sanna Hämäläinen, Matti Nykter, Valentina Taverniti
Publikováno v:
Oncotarget
The proprotein convertase enzyme FURIN processes immature pro-proteins into functional end- products. FURIN is upregulated in activated immune cells and it regulates T-cell dependent peripheral tolerance and the Th1/Th2 balance. FURIN also promotes t