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pro vyhledávání: '"Wilhelm Neubert"'
Autor:
Nagaiah Chamakuri, Janine Vierheller, Martin Falcke, Wilhelm Neubert, Stephen Gilbert, Gerald Warnecke
Publikováno v:
Multiscale Modeling & Simulation. 16:1115-1145
Simulation of electrophysiology and intracellular ${Ca}^{2+}$ dynamics in cardiomyocytes comprises fast stochastic dynamics in tiny subcompartments, partial differential equations (PDEs) with stoch...
Autor:
Filippo Giovanni Cosi, Wolfgang Giese, Wilhelm Neubert, Stefan Luther, Chamakuri Nagaiah, Ulrich Parlitz, Martin Falcke
Publikováno v:
Biophysical Journal
Cardiovascular disease is often related to defects of subcellular components in cardiac myocytes, specifically in the dyadic cleft, which include changes in cleft geometry and channel placement. Modeling of these pathological changes requires both sp
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Frontiers in Physiology
Frontiers in Physiology
Mathematical modeling of excitation-contraction coupling (ECC) in ventricular cardiac myocytes is a multiscale problem, and it is therefore difficult to develop spatially detailed simulation tools. ECC involves gradients on the length scale of 100 nm