Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wilhelm Kump"'
Publikováno v:
Journal of Medicinal Chemistry. 33:552-560
Series of 3-piperidinyl- and 3-piperazinylrifamycins and to a certain extent 3-hydrazonorifamycins all bearing lipophilic side chains were found to exert potent hypolipidemic activity in lowering both serum cholesterol and LDL-cholesterol in rats. St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25e0d0b121a0c2ba07338f9cd94cff2
https://doi.org/10.1021/jm00164a013
https://doi.org/10.1021/jm00164a013
Autor:
Elisabeth Buchdunger, Thomas F. Meyer, Wilhelm Kump, Rihs G, Marcel Muller, Helmut Mett, Pascal Furet, Urs Regenass, Uwe Trinks, Nicholas B. Lydon
Publikováno v:
Journal of medicinal chemistry. 37(7)
Dianilinophthalimides represent a novel class of inhibitors of the EGF-receptor protein tyrosine kinase with a high degree of selectivity versus other tyrosine and serine/threonine kinases. Steady-state kinetic analysis of compound 3, which showed po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a9c0094db6eb9d26a55b1a11f1eb6f
https://pubmed.ncbi.nlm.nih.gov/8151612
https://pubmed.ncbi.nlm.nih.gov/8151612
Autor:
Johanna Geissler, Peter Traxler, Nicholas B. Lydon, Johannes Roesel, Thomas F. Meyer, Wilhelm Kump, Oskar Wacker, Urs Regenass, Ha L. Bach
Publikováno v:
Journal of medicinal chemistry. 34(8)
The synthesis and biological activities of a series of sulfonylbenzoyl-nitrostyrene derivatives, a novel class of selective bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase, are described. The most potent derivatives inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a3f523ae7e8b400c19456664147985
https://pubmed.ncbi.nlm.nih.gov/1652014
https://pubmed.ncbi.nlm.nih.gov/1652014
Publikováno v:
The Journal of Antibiotics. 32:689-705
A number of semisynthetic bicyclomycin derivatives have been prepared by modifications at various sites of the molecule. The preparation, characterization and antimicrobial evaluation of the new compounds is described. In contrast to bicyclomycin its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab599fc253fa75b9dbfd221ad13acf9
https://doi.org/10.7164/antibiotics.32.689
https://doi.org/10.7164/antibiotics.32.689
Publikováno v:
Tetrahedron Letters. 24:5607-5610
A rearrangement of 7-N-methyl-3′-O-benzoyl-( 3 ) and 7,9-N,N-dimethylbicyclomycin ( 5 is described, which proceeds by opening of the aminal diketopiperazine ring and subsequent recyclization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac1ad039c762e8f2bb84571c048e8e7c
https://doi.org/10.1016/s0040-4039(00)94153-4
https://doi.org/10.1016/s0040-4039(00)94153-4
Autor:
Wilhelm Kump, Hans Bickel
Publikováno v:
Helvetica Chimica Acta. 56:2348-2377
The reactivity of rifamycin-S (1) with respect to nucleophilic reagents has been studied. Several new classes of derivatives, some of which show interesting biological activities, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c38da61ac0bd1a5aad433af1bbbf6c7b
https://doi.org/10.1002/hlca.19730560720
https://doi.org/10.1002/hlca.19730560720
Autor:
Wilhelm Kump, Hans Bickel
Publikováno v:
Helvetica Chimica Acta. 56:2323-2347
The reactivity of rifamycin-S with respect to acids, bases, and oxydizing or reducing agents has been studied. A number of compounds resulting from these experiments as well as derivatives of rifamycin-S resulting from acylation and ketalisation reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::180657371a97558e8785d7a1e602da7b
https://doi.org/10.1002/hlca.19730560719
https://doi.org/10.1002/hlca.19730560719
Autor:
Hans Bickel, Wilhelm Kump
Publikováno v:
Chemischer Informationsdienst. 5
Durch Einwirkung aliphatischer Amine, wie z.B. (II), auf Rifamycin-S (1) entstehen die Aminoderivate (III), die nach Oxidation als rot bis schwarzviolett gefarbte Chinone (IV) isoliert werden.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1067c18b03d65f3440eb302efb679e7
https://doi.org/10.1002/chin.197405393
https://doi.org/10.1002/chin.197405393
Autor:
Wilhelm Kump, Hans Bickel
Publikováno v:
Chemischer Informationsdienst. 5
Rifamycin-S (I) wird von wasserfreien Sauren (Ameisensaure, alkoholische und atherische HCl) rasch angegriffen, wobei als Primarprodukt die Verbindung (II) entsteht.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1fe84d33326582cc86a87cbe8bef42
https://doi.org/10.1002/chin.197405394
https://doi.org/10.1002/chin.197405394
CGP 4832, a new semisynthetic rifamycin derivative highly active against some gram-negative bacteria
Publikováno v:
The Journal of antibiotics. 40(12)
CGP 4832 (5) is a new derivative of rifamycin S, showing a very high degree of activity against certain Gram-negative bacteria, with MICs as much as 400 times lower than those of rifampicin. CGP 4832 and rifampicin inhibit DNA-dependent transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c3e0472252bc516d0d1dca5fde50e0
https://pubmed.ncbi.nlm.nih.gov/2448280
https://pubmed.ncbi.nlm.nih.gov/2448280