Výsledky vyhledávání - "Wilhelm Sicking"

Akademický článek

Self-association of an indole based guanidinium-carboxylate-zwitterion: formation of stable dimers in solution and the solid state

Autor: Carolin Rether, Wilhelm Sicking, Roland Boese, Carsten Schmuck

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 3 (2010)

The indole based zwitterion 2 forms stable dimers held together by H-bond assisted ion pairs. Dimerisation was confirmed in the solid state and studied in solution using dilution NMR experiments. Even though zwitterion 2 forms very stable dimers even

Externí odkaz: https://doaj.org/article/2b8dd2d8122d4dd2a080506d578b08c0

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Hierarchical self-assembly of a small monomer with two orthogonal binding sites: from discrete hexagonal containers to a stimuli-responsive supramolecular gel

Autor: Wilhelm Sicking, Kerstin Grossert, Carsten Schmuck, Elio Zellermann

A small self-complementary monomer 1 is described, with two orthogonal binding interactions based on ion pairing and metal-ligand coordination, which is reversibly switchable between monomer, cyclic oligomers as well as linear- and 3D-netlike polymer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622872380d9e07ca5741651ad9109f0c

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DFT Calculations Suggest a New Type of Self-Protection and Self-Inhibition Mechanism in the Mammalian Heme Enzyme Myeloperoxidase: Nucleophilic Addition of a Functional Water rather than One-Electron Reduction

Autor: Wilhelm Sicking, Carsten Schmuck, Holger Somnitz

Publikováno v: Chemistry - A European Journal. 18:10937-10948

The mammalian heme enzyme myeloperoxidase (MPO) catalyzes the reaction of Cl(-) to the antimicrobial-effective molecule HOCl. During the catalytic cycle, a reactive intermediate "Compound I" (Cpd I) is generated. Cpd I has the ability to destroy the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f02e62325da280751ccab35adb0a78
https://doi.org/10.1002/chem.201103477

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Discovery of potent inhibitors of human β-tryptase from pre-equilibrated dynamic combinatorial libraries

Autor: Qian-Qian Jiang, Martin Ehlers, Wilhelm Sicking, Carsten Schmuck

Pre-equilibrated dynamic combinatorial libraries based on acyl hydrazone interchange of peptide-derived hydrazides and di- and tri-aldehydes have been used to discover potent inhibitors with nanomolar affinities for β-tryptase. To identify potent in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8a66cf940ce537292199956d86794d

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The Effect of Pressure on Hydrogen Transfer Reactions with Quinones

Autor: Christoph Rüchardt, Reiner Sustmann, Frank-Gerrit Klärner, Frank Wurche, Wilhelm Sicking

Publikováno v: Chemistry - A European Journal. 10:2707-2721

The effect of pressure on the oxidation of hydroarenes 3-9 with 2,3-dichloro-5,6-dicyano-1,4-quinone (DDQ; 1 a) or o-chloranil (10), leading to the corresponding arenes, has been investigated. The activation volumes were determined from the pressure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f76884bb74dcac943787a7163d4f14
https://doi.org/10.1002/chem.200305686

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A new approach to inhibit human β-tryptase by protein surface binding of four-armed peptide ligands with two different sets of arms

Autor: Lina Bartsch, Carsten Schmuck, Dominik Heider, Peter Wich, Daniel Hoffmann, Wilhelm Sicking, Qian-Qian Jiang

A series of six new tetravalent ligands (1-6) with two different sets of arms bind to the surface of β-tryptase, a tetrameric enzyme with an A(2)B(2) arrangement of its four monomers and two different binding sites on its protein surface (as suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb489b9a05720c948b35a2dc5ede4983
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=84874039506

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A molecular peptide beacon for the ratiometric sensing of nucleic acids

Autor: Chunyan Li, Wilhelm Sicking, Ying Zou, Junchen Wu, Tao Yi, Carsten Schmuck, Ivo Piantanida

Publikováno v: Journal of the American Chemical Society. 134(4)

In conclusion, we have demonstrated that the pyrenefunctionalized oligopeptide 1 can be used as a molecular peptide beacon to sense ds-DNA. Upon binding to nucleic acids 1 undergoes a conformational change from a folded to an extended form which swit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b87f62e4c367416bbf3043081e1034
https://pubmed.ncbi.nlm.nih.gov/22242714

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