Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Wilhelm, Haas"'
Autor:
Yuanli Zhen, Kai Liu, Lei Shi, Simran Shah, Qin Xu, Haley Ellis, Eranga R. Balasooriya, Johannes Kreuzer, Robert Morris, Albert S. Baldwin, Dejan Juric, Wilhelm Haas, Nabeel Bardeesy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genomic alterations that activate Fibroblast Growth Factor Receptor 2 (FGFR2) are common in intrahepatic cholangiocarcinoma (ICC) and confer sensitivity to FGFR inhibition. However, the depth and duration of response is often limited. Here,
Externí odkaz:
https://doaj.org/article/5cd054ddc21245bf928ef895954d9dac
Autor:
Markus W. Schweiger, Zohreh Amoozgar, Pierre Repiton, Robert Morris, Semer Maksoud, Michael Hla, Eric Zaniewski, David P. Noske, Wilhelm Haas, Koen Breyne, Bakhos A. Tannous
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108807- (2024)
Summary: Glioblastoma (GBM) is the most aggressive brain tumor, presenting major challenges due to limited treatment options. Standard care includes radiation therapy (RT) to curb tumor growth and alleviate symptoms, but its impact on GBM is limited.
Externí odkaz:
https://doaj.org/article/db23f5ee32a4459ab10e27118100af65
Autor:
Swetha Rajasekaran, Jalal Siddiqui, Jessica Rakijas, Brandon Nicolay, Chenyu Lin, Eshan Khan, Rahi Patel, Robert Morris, Emanuel Wyler, Myriam Boukhali, Jayashree Balasubramanyam, R. Ranjith Kumar, Capucine Van Rechem, Christine Vogel, Sailaja V. Elchuri, Markus Landthaler, Benedikt Obermayer, Wilhelm Haas, Nicholas Dyson, Wayne Miles
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Swetha Rajasekaran et al. integrate transcriptional, proteomic, and metabolomic data to explore how cells adapt to inactivation of RB1, a hallmark of cancer. Combined with their genetic analyses in a Drosophila model, the authors identify key metabol
Externí odkaz:
https://doaj.org/article/c522d3a225e8419ab1ce5e0411f3ed84
Autor:
Sooncheol Lee, Douglas Micalizzi, Samuel S. Truesdell, Syed I. A. Bukhari, Myriam Boukhali, Jennifer Lombardi-Story, Yasutaka Kato, Min-Kyung Choo, Ipsita Dey-Guha, Fei Ji, Benjamin T. Nicholson, David T. Myers, Dongjun Lee, Maria A. Mazzola, Radhika Raheja, Adam Langenbucher, Nicholas J. Haradhvala, Michael S. Lawrence, Roopali Gandhi, Christopher Tiedje, Manuel D. Diaz-Muñoz, David A. Sweetser, Ruslan Sadreyev, David Sykes, Wilhelm Haas, Daniel A. Haber, Shyamala Maheswaran, Shobha Vasudevan
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-t
Externí odkaz:
https://doaj.org/article/3a979733efdc48f9906f993aa9cadbcb
Autor:
Lizhi He, Jhih-Hua Jhong, Qi Chen, Kai-Yao Huang, Karin Strittmatter, Johannes Kreuzer, Michael DeRan, Xu Wu, Tzong-Yi Lee, Nikolai Slavov, Wilhelm Haas, Alexander G. Marneros
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109955- (2021)
Summary: Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a compreh
Externí odkaz:
https://doaj.org/article/f157ca1578fa466bb58ec28d74dce0d4
Autor:
Maria Paula Zappia, Ana Guarner, Nadia Kellie-Smith, Alice Rogers, Robert Morris, Brandon Nicolay, Myriam Boukhali, Wilhelm Haas, Nicholas J Dyson, Maxim V Frolov
Publikováno v:
eLife, Vol 10 (2021)
The E2F transcription factors play a critical role in controlling cell fate. In Drosophila, the inactivation of E2F in either muscle or fat body results in lethality, suggesting an essential function for E2F in these tissues. However, the cellular an
Externí odkaz:
https://doaj.org/article/8bb9f5a1624748c6b17ec1413f01cbad
Autor:
Ken Tajima, Satoru Matsuda, Toshifumi Yae, Benjamin J. Drapkin, Robert Morris, Myriam Boukhali, Kira Niederhoffer, Valentine Comaills, Taronish Dubash, Linda Nieman, Hongshan Guo, Neelima K. C. Magnus, Nick Dyson, Toshihiro Shioda, Wilhelm Haas, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.
Externí odkaz:
https://doaj.org/article/21e385ead60048f085bedca5bc235b72
Autor:
Lei Shi, William Shen, Mindy I. Davis, Ke Kong, Phuong Vu, Supriya K. Saha, Ramzi Adil, Johannes Kreuzer, Regina Egan, Tobie D. Lee, Patricia Greninger, Jonathan H. Shrimp, Wei Zhao, Ting-Yu Wei, Mi Zhou, Jason Eccleston, Jonathan Sussman, Ujjawal Manocha, Vajira Weerasekara, Hiroshi Kondo, Vindhya Vijay, Meng-Ju Wu, Sara E. Kearney, Jeffrey Ho, Joseph McClanaghan, Ellen Murchie, Giovanna S. Crowther, Samarjit Patnaik, Matthew B. Boxer, Min Shen, David T. Ting, William Y. Kim, Ben Z. Stanger, Vikram Deshpande, Cristina R. Ferrone, Cyril H. Benes, Wilhelm Haas, Matthew D. Hall, Nabeel Bardeesy
Publikováno v:
Nature Cancer. 4:365-381
Autor:
Swetha Rajasekaran, Jalal Siddiqui, Jessica Rakijas, Brandon Nicolay, Chenyu Lin, Eshan Khan, Rahi Patel, Robert Morris, Emanuel Wyler, Myriam Boukhali, Jayashree Balasubramanyam, R. Ranjith Kumar, Capucine Van Rechem, Christine Vogel, Sailaja V. Elchuri, Markus Landthaler, Benedikt Obermayer, Wilhelm Haas, Nicholas Dyson, Wayne Miles
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/35e9a7db329246f0b30b2c0bbe0dc5d6
Autor:
Syed IA Bukhari, Samuel S Truesdell, Chandreyee Datta, Pritha Choudhury, Keith Q Wu, Jitendra Shrestha, Ruby Maharjan, Ethan Plotsker, Ramzi Elased, Sadia Laisa, Vijeta Bhambhani, Yue Lin, Johannes Kreuzer, Robert Morris, Siang-Boon Koh, Leif W. Ellisen, Wilhelm Haas, Amy Ly, Shobha Vasudevan
Publikováno v:
bioRxiv
Our data previously revealed that chemosurviving cancer cells translate specific genes. Here, we find that the m6A-RNA-methyltransferase, METTL3, increases transiently in chemotherapy-treated breast cancer and leukemic cells in vitro and in vivo. Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c648e406c889874ee2a350109453e95
https://doi.org/10.1101/2023.05.19.540602
https://doi.org/10.1101/2023.05.19.540602