Novel antisense therapy targeting microRNA-132 in patients with heart failure

Autor: Henning Weigt, Thomas Thum, Celina Genschel, Carmen Theek, Sandor Batkai, Jorg Taubel, Wilfried Hauke, L Rode, Janika Viereck, Ulrike Lorch, Steffen Rump, Scott D. Solomon, Arthur A. Levin, Jenny Poetzsch, Johann Bauersachs

Publikováno v: European Heart Journal. 42

Background Cardiac microRNA-132-3p (miR-132) levels are increased in patients with heart failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a specific antisense oligonucleotide, is a first-in-class miR-132 inhibitor that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b365775ba88ccc4f41b7e9d94bb90ff6
https://doi.org/10.1093/eurheartj/ehab724.0920

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Autor: Arthur A. Levin, Wilfried Hauke, Johann Bauersachs, Janika Viereck, Carmen Theek, Jorg Taubel, Sandor Batkai, Henning Weigt, Ulrike Lorch, Jenny Poetzsch, Thomas Thum, Steffen Rump, Scott D. Solomon, Celina Genschel, Laura Rode

Publikováno v: Eur Heart J

Aims Cardiac microRNA-132-3p (miR-132) levels are increased in patients with heart failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a specific antisense oligonucleotide, is a first-in-class miR-132 inhibitor that attenua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9fc33d22ac80be6240b19573df4532
https://pubmed.ncbi.nlm.nih.gov/33338200

Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction:MITOCARE study results

Autor: Huseyin Firat, Hélène Rousseau, Franck Paganelli, Wilfried Hauke, Giles Sonou, Dan Atar, Sophie Schaller, Henrik Steen Hansen, Håkan Arheden, Vegard Tuseth, Svend Eggert Jensen, Eric Vicaut, Philippe Le Corvoisier, Nicolas Danchin, Rebecca M. Pruss, Alain Berdeaux, Sasha Koul, A.I Larsen, Henrik Engblom, Jan Erik Nordrehaug, Marcus Carlsson, Jean-Louis Bonnet, Julien Veys, Jean-Luc Dubois-Randé, Einar Heiberg, Sigrun Halvorsen, Peter Clemmensen, David Erlinge, Valerie Cuvier

Publikováno v: Atar, D, Arheden, H, Berdeaux, A, Bonnet, J-L, Carlsson, M, Clemmensen, P, Cuvier, V, Danchin, N, Dubois-Randé, J-L, Engblom, H, Erlinge, D, Firat, H, Halvorsen, S, Hansen, H S, Hauke, W, Heiberg, E, Koul, S, Larsen, A-I, Le Corvoisier, P, Nordrehaug, J E, Paganelli, F, Pruss, R M, Rousseau, H, Schaller, S, Sonou, G, Tuseth, V, Veys, J, Vicaut, E & Jensen, S E 2015, ' Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction : MITOCARE study results ', European Heart Journal, vol. 36, no. 2, pp. 112-119 . https://doi.org/10.1093/eurheartj/ehu331

AIM: The MITOCARE study evaluated the efficacy and safety of TRO40303 for the reduction of reperfusion injury in patients undergoing revascularization for ST-elevation myocardial infarction (STEMI).METHODS: Patients presenting with STEMI within 6 h o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733cffb561325db7f00d169b5c01a04d
https://vbn.aau.dk/da/publications/2fa06c1b-274c-4aa6-add7-8f977d136605

Esberitox® N as Supportive Therapy when Providing Standard Antibiotic Treatment in Subjects with a Severe Bacterial Infection (Acute Exacerbation of Chronic Bronchitis)

Autor: Wilfried Hauke, Hans-Heinrich Henneicke-von Zepelin, Gert Köhler, J. Freudenstein

Publikováno v: Chemotherapy. 48:259-266

53 patients with planned antibiotic therapy for the treatment of acute exacerbation of chronic bronchitis as an example of a severe bacterial infection requiring antibiotics were included in a prospective, multicentre, double-blind, placebo-controlle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b03e1502940f38f0e4e0684ea4c7e03a
https://doi.org/10.1159/000066763