Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Wilfried, Roth"'
Autor:
Tanwei Yuan, Durgesh Wankhede, Dominic Edelmann, Jakob Nikolas Kather, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Bläker, Hermann Brenner, Michael Hoffmeister
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105223- (2024)
Summary: Background: DNA methylation biomarkers in colorectal cancer (CRC) tissue hold potential as prognostic indicators. However, individual studies have yielded heterogeneous results, and external validation is largely absent. We conducted a compr
Externí odkaz:
https://doaj.org/article/518c1ff42f2c448688715029556177d7
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Deleterious mutations in the BRCA1 and BRCA2 genes have significant therapeutic relevance in clinical settings regarding personalized therapy approaches. BRCA1 and BRCA2 play a pivotal role in homologous recombination (HR) and thus are sensi
Externí odkaz:
https://doaj.org/article/9b46acf41d8c4a2486842ace7658b395
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
IntroductionMediastinal tumors, particularly non-neuroendocrine thymic epithelial tumors (TET) are relatively uncommon, posing challenges for extensive epidemiological studies. This study presents a comprehensive analysis of these tumors in the Unite
Externí odkaz:
https://doaj.org/article/e0926d8e444b45d5a05a2669bca66fe3
Autor:
Elizabeth Alwers, Jakob N Kather, Matthias Kloor, Alexander Brobeil, Katrin E Tagscherer, Wilfried Roth, Amelie Echle, Efrat L Amitay, Jenny Chang‐Claude, Hermann Brenner, Michael Hoffmeister
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 129-136 (2023)
Abstract In addition to the traditional staging system in colorectal cancer (CRC), the Immunoscore® has been proposed to characterize the level of immune infiltration in tumor tissue and as a potential prognostic marker. The aim of this study was to
Externí odkaz:
https://doaj.org/article/4c9e90af24084aecaf17e369708cd7af
Autor:
Mark Kriegsmann, Katharina Kriegsmann, Georg Steinbuss, Christiane Zgorzelski, Thomas Albrecht, Stefan Heinrich, Stefan Farkas, Wilfried Roth, Hien Dang, Anne Hausen, Matthias M. Gaida
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 7, Pp n/a-n/a (2023)
Abstract Introduction Differentiation of histologically similar structures in the liver, including anatomical structures, benign bile duct lesions, or common types of liver metastases, can be challenging with conventional histological tissue sections
Externí odkaz:
https://doaj.org/article/44754a9766534839b9554ca474ae4822
Autor:
Sabrina Saurin, Myriam Meineck, Markus Rohr, Wilfried Roth, Till Opatz, Gerhard Erkel, Andrea Pautz, Julia Weinmann-Menke
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Renal fibrosis is one of the most important triggers of chronic kidney disease (CKD), and only a very limited number of therapeutic options are available to stop fibrosis progression. As fibrosis is characterized by inflammation, myofibro
Externí odkaz:
https://doaj.org/article/5dfc4fcf6eb3433ab945c4433729a681
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Recent progress in clinical development of KRAS inhibitors has raised interest in predicting the tumor dependency on frequently mutated RAS-pathway oncogenes. However, even without such activating mutations, RAS proteins represent core compo
Externí odkaz:
https://doaj.org/article/3b591d121aef4996b4a74ce7230c45aa
Autor:
Tiemo Sven Gerber, Hagen Roland Witzel, Arndt Weinmann, Fabian Bartsch, Mario Schindeldecker, Peter R. Galle, Hauke Lang, Wilfried Roth, Dirk Andreas Ridder, Beate Katharina Straub
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2471 (2023)
Primary liver cancer, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), remains a significant contributor to cancer-related mortality worldwide. Oxidative stress and lipid peroxidation play a key role in chronic liv
Externí odkaz:
https://doaj.org/article/eccc38e9d7e84802ab15d066b62b3733
Autor:
Aurelia Noske, Daniel-Christoph Wagner, Kristina Schwamborn, Sebastian Foersch, Katja Steiger, Marion Kiechle, Dirk Oettler, Siranush Karapetyan, Alexander Hapfelmeier, Wilfried Roth, Wilko Weichert
Publikováno v:
Breast, Vol 60, Iss , Pp 238-244 (2021)
Different immunohistochemical programmed death-ligand 1 (PD-L1) assays and scorings have been reported to yield variable results in triple-negative breast cancer (TNBC). We compared the analytical concordance and reproducibility of four clinically re
Externí odkaz:
https://doaj.org/article/6df245d0b4404ea2aae7789f9bb50efa
Autor:
Anna Haupts, Anne Vogel, Sebastian Foersch, Monika Hartmann, Annett Maderer, Nicolas Wachter, Tobias Huber, Werner Kneist, Wilfried Roth, Hauke Lang, Markus Moehler, Nils Hartmann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The current standard for molecular profiling of colorectal cancer (CRC) is using resected or biopsied tissue specimens. However, they are limited regarding sampling frequency, representation of tumor heterogeneity, and sampling can expose pa
Externí odkaz:
https://doaj.org/article/a0ed0fa91b424f0dac5d064546a90fbe