Selection of a novel strain of Christensenella minuta as a future biotherapy for Crohn’s disease

Autor: Karima Relizani, Katy Le Corf, Camille Kropp, Rebeca Martin-Rosique, Déborah Kissi, Guillaume Déjean, Lisa Bruno, Ccori Martinez, Georges Rawadi, Frédéric Elustondo, Wilfrid Mazier, Sandrine P. Claus

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract Microbiome-based therapies for inflammatory bowel diseases offer a novel and promising therapeutic approach. The human commensal bacteria of the species Christensenella minuta (C. minuta) have been reported consistently missing in patients a

Externí odkaz: https://doaj.org/article/7924a0febbf4419998171066a6578be0

Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats

Autor: Marie Lods, Emilie Pacary, Wilfrid Mazier, Fanny Farrugia, Pierre Mortessagne, Nuria Masachs, Vanessa Charrier, Federico Massa, Daniela Cota, Guillaume Ferreira, Djoher Nora Abrous, Sophie Tronel

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

The role of adult hippocampal neurogenesis in memory reconsolidation is unclear. Here, the authors show that memory retrieval activates both immature and mature adult-born neurons. However, only adult-born neurons immature during learning are require

Externí odkaz: https://doaj.org/article/bae95052d3bc4bb8ba065eba88030b99

Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

Autor: Sergio Valbuena, Álvaro García, Wilfrid Mazier, Ana V. Paternain, Juan Lerma

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of

Externí odkaz: https://doaj.org/article/d263a07d71f248b588f195680de08d05

A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases

Autor: Wilfrid Mazier, Katy Le Corf, Ccori Martinez, Héloïse Tudela, Déborah Kissi, Camille Kropp, Chrislain Coubard, Marion Soto, Frédéric Elustondo, Georges Rawadi, Sandrine P. Claus

Publikováno v: Cells, Vol 10, Iss 4, p 823 (2021)

Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae family have been proposed to act as keystones of the human gut ecosystem and to prevent adip

Externí odkaz: https://doaj.org/article/49d113ac22db489e817fc04cebdc3f1c

The temporal origin of dentate granule neurons dictates their role in spatial memory

Autor: Daniela Cota, Valérie Lemaire, Marie-Françoise Montaron, Fanny Farrugia, Shaoyu Ge, Sophie Tronel, Vanessa Charrier, Wilfrid Mazier, Giovanni Marsicano, Nicolas Blin, Cyril Herry, Nuria Masachs, Djoher Nora Abrous, Véronique Deroche-Gamonet

Publikováno v: Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2021, ⟨10.1038/s41380-021-01276-x⟩
Molecular Psychiatry, Nature Publishing Group, 2021, 26 (12), pp.7130-7140. ⟨10.1038/s41380-021-01276-x⟩

The dentate gyrus is one of the only brain regions that continues its development after birth in rodents. Adolescence is a very sensitive period during which cognitive competences are programmed. We investigated the role of dentate granule neurons (D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b9d80ffdddc8aa6ebc1c8ae0e97e7c
https://hal.archives-ouvertes.fr/hal-03420311