Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wilfredo Marin"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Humoral primary immunodeficiencies are the most prevalent form of primary immunodeficiency (PID). Currently, there is no convenient method to quantify newly formed B cells. The aim of this proof-of-concept study was to quantitate the ratio o
Externí odkaz:
https://doaj.org/article/90b350488c8b4fe68f2f7ec57f116a18
Autor:
Elisha D. O. Roberson, Rosana A. Mesa, Gabrielle A. Morgan, Li Cao, Wilfredo Marin, Lauren M. Pachman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-22 (2022)
Abstract In juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, weakness is accompanied by a characteristic rash that often becomes chronic and is associated with vascular damage. We hoped to understand the molecular unde
Externí odkaz:
https://doaj.org/article/87f7f95adc9f4d5db7f9aaaaba33cec7
Autor:
Ameera Bukhari, Amer Khojah, Wilfredo Marin, Andrey Khramtsov, Galina Khramtsova, Christopher Costin, Gabrielle Morgan, Prathyaya Ramesh, Marisa S. Klein-Gitelman, I. Caroline Le Poole, Lauren M. Pachman
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10553 (2023)
Otoferlin mRNA expression is increased in JDM patients’ PBMCs and muscle compared to healthy controls. This study aims to evaluate the role of otoferlin in JDM disease pathophysiology and its association with disease activity in untreated children
Externí odkaz:
https://doaj.org/article/fee98d5fa15a414f9455ee8190f840ea
Autor:
Shefa M. Tawalbeh, Wilfredo Marin, Gabrielle A. Morgan, Utkarsh J. Dang, Yetrib Hathout, Lauren M. Pachman
Publikováno v:
BMC Rheumatology, Vol 4, Iss 1, Pp 1-15 (2020)
Abstract Background Blood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associated with clinical dise
Externí odkaz:
https://doaj.org/article/8adedddc628b4e898ac8d2a8cafc5b96
Autor:
Tohei Yokogawa, Wilfredo Marin, Juliette Faraco, Guillaume Pézeron, Lior Appelbaum, Jian Zhang, Frédéric Rosa, Philippe Mourrain, Emmanuel Mignot
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e277 (2007)
Sleep is a fundamental biological process conserved across the animal kingdom. The study of how sleep regulatory networks are conserved is needed to better understand sleep across evolution. We present a detailed description of a sleep state in adult
Externí odkaz:
https://doaj.org/article/acfbb84fc62d4fdc8ad520e87546c733
Autor:
Gabrielle A. Morgan, Yetrib Hathout, Shefa M. Tawalbeh, Wilfredo Marin, Utkarsh J. Dang, Lauren M. Pachman
Publikováno v:
BMC Rheumatology, Vol 4, Iss 1, Pp 1-15 (2020)
BackgroundBlood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associated with clinical disease activi
Publikováno v:
Journal of Visualized Experiments.
Heterogeneous cell populations, from either healthy or malignant tissues, may contain a population of cells characterized by a differential ability to efflux the DNA-binding dye Hoechst 33342. This "side population" of cells can be identified using f
Autor:
Adi Tovin, Koichi Kawakami, Lior Appelbaum, Emmanuel Mignot, Gordon X. Wang, Stephen J. Smith, Wilfredo Marin, Rotem Mori, Philippe Mourrain, Géraldine S. Maro, Yoav Gothilf, Tohei Yokogawa
Publikováno v:
Proceedings of the National Academy of Sciences. 106:21942-21947
In mammals, hypocretin/orexin (HCRT) neuropeptides are important sleep–wake regulators and HCRT deficiency causes narcolepsy. In addition to fragmented wakefulness, narcoleptic mammals also display sleep fragmentation, a less understood phenotype r
Autor:
Emmanuel Mignot, Stephanie E. Gaus, Juliette Faraco, Wilfredo Marin, Philippe Mourrain, Lior Appelbaum
Publikováno v:
Journal of Biological Chemistry. 281:29753-29761
Hypocretins/orexins are neuropeptides involved in the regulation of sleep and energy balance in mammals. Conservation of gene sequence, hypothalamic localization of cell bodies, and projection patterns in adult zebrafish suggest that the architecture
Autor:
Wilfredo Marin, Anthony C. Restaino, Jill L. O. de Jong, Sean C. McConnell, Margaret M. Pruitt
Publikováno v:
Blood. 126:1236-1236
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that accounts for 15% of pediatric and 25% of adult ALL cases. While initial treatment of T-ALL has improved, relapse is common and is associated with a poor prognosis. As with o