Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19

Autor: Kritika Khanna, Wilfred W. Raymond, Jing Jin, Annabelle R. Charbit, Irina Gitlin, Monica Tang, Adam D. Werts, Edward G. Barrett, Jason M. Cox, Sharla M. Birch, Rachel Martinelli, Hannah S. Sperber, Sergej Franz, Thomas Duff, Markus Hoffmann, Anne Marie Healy, Stefan Oscarson, Stefan Pöhlmann, Satish K. Pillai, Graham Simmons, John V. Fahy

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L372-L389

The redox status of the cysteine-rich SARS-CoV-2 spike glycoprotein (SARS-2-S) is important for the binding of SARS-2-S to angiotensin-converting enzyme 2 (ACE2), suggesting that drugs with a functional thiol group (“thiol drugs”) may cleave cyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed0e1d52f190a90985b7184a51c0b59
https://doi.org/10.1152/ajplung.00136.2022

Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.

Autor: Shilpa Nimishakavi, Wilfred W Raymond, Dieter C Gruenert, George H Caughey

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0141169 (2015)

Tryptic serine proteases of bronchial epithelium regulate ion flux, barrier integrity, and allergic inflammation. Inhibition of some of these proteases is a strategy to improve mucociliary function in cystic fibrosis and asthmatic inflammation. Sever

Externí odkaz: https://doaj.org/article/b88659b513e64bf6880afc0a97be084c

Ex Vivo Sputum Analysis Reveals Impairment of Protease-dependent Mucus Degradation by Plasma Proteins in Acute Asthma

Autor: Anh L. Innes, Ryan H. Dougherty, George H. Caughey, Susan J. Muller, Sara Kirkham, John V. Fahy, David J. Thornton, Wilfred W. Raymond, Karine Rousseau, Stephen D. Carrington

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 180:203-210

Airway mucus plugs, composed of mucin glycoproteins mixed with plasma proteins, are an important cause of airway obstruction in acute severe asthma, and they are poorly treated with current therapies.To investigate mechanisms of airway mucus clearanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d4391b2b55d13406dd1993fa6d5f97
https://doi.org/10.1164/rccm.200807-1056oc

Chimerism, point mutation, and truncation dramatically transformed mast cell δ-tryptases during primate evolution

Autor: Neil N. Trivedi, Wilfred W. Raymond, George H. Caughey

Publikováno v: Journal of Allergy and Clinical Immunology. 121:1262-1268

Background Tryptases are serine peptidases stored in mast cell granules. Rodents express 2 soluble tryptases, mast cell proteases (MCPs) 6 and 7. Human α- and β-tryptases are orthologs of MCP-6. However, much of the ancestral MCP-7 ortholog was rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a68ae87ba882545b1e1663fb4ef3fb
https://doi.org/10.1016/j.jaci.2008.01.019

Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases

Autor: George H. Caughey, Wilfred W. Raymond, Dieter C. Gruenert, Shilpa Nimishakavi

Publikováno v: PloS one, vol 10, iss 10
Nimishakavi, S; Raymond, WW; Gruenert, DC; & Caughey, GH. (2015). Divergent inhibitor susceptibility among airway lumen-accessible tryptic proteases. PLoS ONE, 10(10), e0141169. doi: 10.1371/journal.pone.0141169. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8t843031
PLoS ONE, Vol 10, Iss 10, p e0141169 (2015)
PLoS ONE

Tryptic serine proteases of bronchial epithelium regulate ion flux, barrier integrity, and allergic inflammation. Inhibition of some of these proteases is a strategy to improve mucociliary function in cystic fibrosis and asthmatic inflammation. Sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460a1ea584ddb1e51a819f3327164374
https://escholarship.org/uc/item/8t843031