Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition

Autor: Haruka Wada, Ryo Otsuka, Wilfred T V Germeraad, Tomoki Murata, Toru Kondo, Ken-ichiro Seino

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 11 (2023)

Background The cancer stem cell theory proposes that tumor formation in vivo is driven only by specific tumor-initiating cells having stemness; however, clinical trials conducted to test drugs that target the tumor stemness provided unsatisfactory re

Externí odkaz: https://doaj.org/article/ccdcee806cc94ceeacaa7d55b876fae2

Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-γ

Autor: Tammy Oth, Thomas H. P. M. Habets, Wilfred T. V. Germeraad, Marijke I. Zonneveld, Gerard M. J. Bos, Joris Vanderlocht

Publikováno v: BMC Immunology, Vol 19, Iss 1, Pp 1-13 (2018)

Abstract Background Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendr

Externí odkaz: https://doaj.org/article/0626c82c7482453e9eb0f80a81265a07

Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor

Autor: Ying Gong, Gerard M. J. Bos, Ian Janssen, Roel G. J. Klein Wolterink, Arjan J. Groot, Wilfred T. V. Germeraad

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy-Methods and Clinical Development, 17, 634-646. Nature Publishing Group
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 634-646 (2020)

Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent years, but improvements are needed. Genetic modification of NK cells with a tumor antigen-specific receptor on their surface coupled to intracellular signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724894981c6afdce3e5ff4894ff0e3f7
http://europepmc.org/articles/PMC7150439

Fractionated Radiotherapy with 3 x 8 Gy Induces Systemic Anti-Tumour Responses and Abscopal Tumour Inhibition without Modulating the Humoral Anti-Tumour Response.

Autor: Thomas H P M Habets, Tammy Oth, Ans W Houben, Mirelle J A J Huijskens, Birgit L M G Senden-Gijsbers, Melanie C A Schnijderberg, Boudewijn Brans, Ludwig J Dubois, Philippe Lambin, Marijke De Saint-Hubert, Wilfred T V Germeraad, Marcel G J Tilanus, Felix M Mottaghy, Gerard M J Bos, Joris Vanderlocht

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159515 (2016)

Accumulating evidence indicates that fractionated radiotherapy (RT) can result in distant non-irradiated (abscopal) tumour regression. Although preclinical studies indicate the importance of T cells in this infrequent phenomenon, these studies do not

Externí odkaz: https://doaj.org/article/19bc78f882ea4f7caa6a85b3c6b4f0fd

Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy

Autor: Wilfred T. V. Germeraad, Roel G. J. Klein Wolterink, Jianxiang Wang, Gerard M. J. Bos, Ying Gong

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-35 (2021)
Journal of Hematology & Oncology

Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically modified to obtain capable effector cells for adoptive cellular treatment of cancer patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4ed771aee45b8d87d30d3b1b6400a2
https://doi.org/10.1186/s13045-021-01083-5