Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Wilfred J. Poppinga"'
Autor:
Hoeke A. Baarsma, Bing Han, Wilfred J. Poppinga, Saskia Driessen, Carolina R. S. Elzinga, Andrew J. Halayko, Herman Meurs, Harm Maarsingh, Martina Schmidt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruc
Externí odkaz:
https://doaj.org/article/2689a820502b4991a3bb1673a2f9baab
Autor:
Haoxiao Zuo, Marina Trombetta-Lima, Irene H. Heijink, Christina H. T. J. van der Veen, Laura Hesse, Klaas Nico Faber, Wilfred J. Poppinga, Harm Maarsingh, Viacheslav O. Nikolaev, Martina Schmidt
Publikováno v:
Cells, Vol 9, Iss 2, p 356 (2020)
Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-β1 (TGF-β1) mediated EMT. Although compartmentalization via A-kin
Externí odkaz:
https://doaj.org/article/9214b914e148402f9ef01cfa0983330b
Autor:
Irene H. Heijink, Viacheslav O. Nikolaev, Haoxiao Zuo, Klaas Nico Faber, Wilfred J. Poppinga, H. Maarsingh, And Martina Schmidt, Christina H T J van der Veen, Marina Trombetta-Lima, Laura Hesse
Publikováno v:
Cells, Vol 9, Iss 2, p 356 (2020)
Cells, 9(2):356. MDPI AG
Cells
Volume 9
Issue 2
Cells, 9(2):356. MDPI AG
Cells
Volume 9
Issue 2
Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-&beta
1 (TGF-&beta
1) mediated EMT. Although compartmenta
1 (TGF-&beta
1) mediated EMT. Although compartmenta
Autor:
Haoxiao Zuo, Laura Hesse, Martina Schmidt, Viacheslav O. Nikolaev, Christina H.J.T. van der Veen, Wilfred J. Poppinga, Irene H. Heijink, Klaas Nico Faber, Harm Maarsingh
Epithelial-to-mesenchymal transition (EMT) plays a role in chronic obstructive pulmonary diseases (COPD). Cyclic adenosine monophosphate (cAMP) can inhibit transforming growth factor-β1 (TGF-β1) mediated EMT. Although compartmentalization via A-kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf594cd8222f0a7ee2235715ad66fab
Autor:
Viacheslav O. Nikolaev, Reinoud Gosens, Martina Schmidt, Andrew J. Halayko, Bing Han, Haoxiao Zuo, Loes E. M. Kistemaker, Lennard Ringnalda, Wilfred J. Poppinga
Publikováno v:
British Journal of Pharmacology
British Journal of Pharmacology, 175(14), 2988-3006. Wiley-Blackwell
British Journal of Pharmacology, 175(14), 2988-3006. Wiley-Blackwell
BACKGROUND AND PURPOSE: 3', 5'-cyclic adenosine monophosphate (cAMP) is a central second messenger that broadly regulates cell function and can underpin pathophysiology. In chronic obstructive pulmonary disease (COPD), a lung disease primarily provok
Publikováno v:
British Journal of Pharmacology. 171:5603-5623
The universal second messenger cAMP is generated upon stimulation of Gs protein-coupled receptors, such as the β2-adreneoceptor, and leads to the activation of PKA, the major cAMP effector protein. PKA oscillates between an on and off state and ther
Autor:
Herman Meurs, Martina Schmidt, Harold G. de Bruin, Anouk Oldenburger, Irene H. Heijink, Fleur Kos, Wim Timens, Wolter Rijks, Wilfred J. Poppinga, H. Maarsingh
Publikováno v:
American Journal of Physiology-Cell Physiology, 306(6), C585-C597. AMER PHYSIOLOGICAL SOC
Airway epithelium, which forms the first barrier towards environmental insults, is disturbed by cigarette smoking, a major risk factor for developing chronic obstructive pulmonary disease (COPD). A-kinase anchoring proteins (AKAP) maintain endothelia
Autor:
Wim De Jager, Sepp R. Jansen, Xiaodong C Cheng, Thomas Wieland, Stephen J. Yarwood, Wilfred J. Poppinga, Reinoud Gosens, Frank Lezoualc'h, Martina Schmidt
Publikováno v:
Oncotarget, 7(29), 46354-46370. Impact Journals LLC
Oncotarget
Oncotarget
// Sepp R. Jansen 1, 4 , Wilfred J. Poppinga 1 , Wim de Jager 1 , Frank Lezoualc’h 2 , Xiaodong Cheng 3 , Thomas Wieland 4 , Stephen J. Yarwood 5 , Reinoud Gosens 1 , Martina Schmidt 1 1 Department of Molecular Pharmacology, Groningen Research Inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd7e198ca04fa9a9cb79d42f19691a9
https://research.rug.nl/en/publications/832f09ed-d9dd-44e0-90f7-96240b0cf234
https://research.rug.nl/en/publications/832f09ed-d9dd-44e0-90f7-96240b0cf234
Autor:
Haoxiao Zuo, P. Vogelaar, Bing Han, Guido Krenning, H. Maarsingh, Bernard van Vliet, Marieke Smit, Stef Stienstra, Robert H. Henning, Annet B. Zuidhof, Herman Meurs, Andrew J. Halayko, Adrianus Cornelis Van Der Graaf, I. Sophie T. Bos, Wilfred J. Poppinga, Martina Schmidt
Publikováno v:
Scientific Reports
Scientific Reports, 6:26928, 1-13. Nature Publishing Group
Scientific Reports, 6:26928, 1-13. Nature Publishing Group
COPD is characterized by persistent airflow limitation, neutrophilia and oxidative stress from endogenous and exogenous insults. Current COPD therapy involving anticholinergics, β2-adrenoceptor agonists and/or corticosteroids, do not specifically ta
Autor:
Martina Schmidt, Elisabeth Zeisberg, Haoxiao Zuo, Wilfred J. Poppinga, Viacheslav O. Nikolaev
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 193:A5870. AMER THORACIC SOC
RATIONALE Cyclic AMP (cAMP) is one of the most important second messengers and is involved as a target for the therapy of chronic obstructive pulmonary disease (COPD), an airway disease primarily provoked by cigarette smoke . Cyclic nucleotide hydrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77694bad1194e586569a361e4b418ef
https://research.rug.nl/en/publications/80695860-8a9d-420a-8153-0d43c4e94a8b
https://research.rug.nl/en/publications/80695860-8a9d-420a-8153-0d43c4e94a8b