Výsledky vyhledávání - "Wilfred D. Vieira"

NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation

Autor: Vincent J. Hearing, Julio C. Valencia, Wilfred D. Vieira, Atsushi Tanemura, Ichiro Katayama, Yasuhiko Kaneko, Lanlan Yin, Kenta Nakamura, Sergio G. Coelho, Hiroo Yokozeki, Yutaka Kawakami, Takeshi Namiki, Masakazu Kawaguchi, Tomonori Yaguchi

Publikováno v: Cancer Research. 75:2708-2715

The AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes, but its therapeutic utility has yet to be confirmed. In this study, we show how its genetic amplification in PTEN-deficient melanomas may rationalize the use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822c1e440882db78a1c47dd278390f66
https://doi.org/10.1158/0008-5472.can-13-3209

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Mechanical properties of the tumor stromal microenvironment probed in vitro and ex vivo by in situ-calibrated optical trap-based active microrheology

Autor: King Leung Fung, Kandice Tanner, Alexus Devine, Ross Lake, Jack R. Staunton, Wilfred D. Vieira

One of the hallmarks of the malignant transformation of epithelial tissue is the modulation of stromal components of the microenvironment. In particular, aberrant extracellular matrix (ECM) remodeling and stiffening enhances tumor growth and survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b24ff56134f077fe6218ac939da6bf9
https://europepmc.org/articles/PMC5065074/

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Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival

Autor: Kandice Tanner, Anna Afasizheva, King Leung Fung, Benjamin H. Blehm, Emily I. Chen, Heather Tillman, Wilfred D. Vieira, Yorihisa Kotobuki, Ben Busby, Alexus Devine

Publikováno v: BMC Cancer

Background Intrinsic and acquired resistance to drug therapies remains a challenge for malignant melanoma patients. Intratumoral heterogeneities within the tumor microenvironment contribute additional complexity to the determinants of drug efficacy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c0599b327112fd6eb2497b86aab3bb
https://doi.org/10.1186/s12885-016-2211-7

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The Role of Abcb5 Alleles in Susceptibility to Haloperidol-Induced Toxicity in Mice and Humans

Publikováno v: PLoS Medicine, Vol 12, Iss 2, p e1001782 (2015)
PLoS Medicine

Background We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability to optimally utilize existing drugs or to develop new drugs for CNS disorders.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6396772f7ae104998a03aebf2fd99d
https://doi.org/10.1371/journal.pmed.1001782

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Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes

Autor: Yuji Yamaguchi, Hidenori Watabe, Julio C. Valencia, Vincent J. Hearing, Ettore Appella, An Chi, Kevin G. Chen, Kaoruko Takahashi, Jeffrey Shabanowitz, Wilfred D. Vieira, Werner Berens, Francois Rouzaud, Kunio Nagashima, Donald F. Hunt

Publikováno v: Journal of Cell Science. 119:1080-1091

Adaptor proteins (AP) play important roles in the sorting of proteins from the trans-Golgi network, but how they function in the sorting of various melanosome-specific proteins such as Pmel17, an essential structural component of melanosomes, in mela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc262a7ef306a62cbc660cee0cef431
https://doi.org/10.1242/jcs.02804

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Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein

Autor: Kazumasa Wakamatsu, Francisco Solano, M. Lynn Lamoreux, Shosuke Ito, Gertrude-E. Costin, Adina L. Milac, Yuji Yamaguchi, Vincent J. Hearing, Andrei J. Petrescu, Francois Rouzaud, Wilfred D. Vieira, Julio C. Valencia

Publikováno v: Biochemical Journal. 391:249-259

Dopachrome tautomerase (Dct) is a type I membrane protein and an important regulatory enzyme that plays a pivotal role in the biosynthesis of melanin and in the rapid metabolism of its toxic intermediates. Dct-mutant melanocytes carrying the slaty or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3878d2d5853a9dd04d031d38ca2d76e7
https://doi.org/10.1042/bj20042070

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The Melanosome: An Ideal Model to Study Cellular Differentiation

Autor: Francois Rouzaud, Julio C. Valencia, Hidenori Watabe, Wilfred D. Vieira, Kazutomo Toyofuku, Gertrude E. Costin, Ken Ichi Yasumoto, Vincent J. Hearing, Tsuneto Kushimoto

Publikováno v: Pigment Cell Research. 16:237-244

Melanosomes provide an intriguing model for study at many levels. In part this is due to their unique structure and function, but also in part to their involvement in pigmentary diseases and as a model to study basic cellular mechanisms of organelle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5a8cb5091a8b9d196b1cc24a80c8f3b
https://doi.org/10.1034/j.1600-0749.2003.00034.x

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