Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Wilfred A Jefferies"'
Autor:
Sara M Wilcox, Hitesh Arora, Lonna Munro, Jian Xin, Franz Fenninger, Laura A Johnson, Cheryl G Pfeifer, Kyung Bok Choi, Juan Hou, Pamela A Hoodless, Wilfred A Jefferies
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175918 (2017)
ABCF1 is an ABC transporter family protein that has been shown to regulate innate immune response and is a risk gene for autoimmune pancreatitis and arthritis. Unlike other members of ABC transporter family, ABCF1 lacks trans-membrane domains and is
Externí odkaz:
https://doaj.org/article/e9fcf0b85ad74a9ba9f1b33ba3fca0f6
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Elevation of intracellular calcium ion (Ca2+) levels is a vital event that regulates T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The mechanisms that regulate intracellular Ca2+ signalling in lymphocytes involv
Externí odkaz:
https://doaj.org/article/4ac15bd757264a0fbb296cbcd1cb8755
Autor:
Giorgia Caspani, Simon G.D. Ruffell, WaiFung Tsang, Nigel Netzband, Cyrus Rohani-Shukla, Jonathan R. Swann, Wilfred A. Jefferies
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107338- (2024)
Psychedelics have emerged as promising therapeutics for several psychiatric disorders. Hypotheses around their mechanisms have revolved around their partial agonism at the serotonin 2 A receptor, leading to enhanced neuroplasticity and brain connecti
Externí odkaz:
https://doaj.org/article/6e4a88bcdad14aa0b2bdd5a33c924e0c
Autor:
Clara Wenjing Xia, Iryna Saranchova, Pablo L. Finkel, Stephanie Besoiu, Lonna Munro, Cheryl G. Pfeifer, Anne Haegert, Yen-Yi Lin, Stéphane Le Bihan, Colin Collins, Wilfred A. Jefferies
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less attention,
Externí odkaz:
https://doaj.org/article/8854a3ed87764c5097f60d12e326c0ff
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23789 (2011)
Evidence of reduced blood-brain barrier (BBB) integrity preceding other Alzheimer's disease (AD) pathology provides a strong link between cerebrovascular angiopathy and AD. However, the "Vascular hypothesis", holds that BBB leakiness in AD is likely
Externí odkaz:
https://doaj.org/article/f8f3248a874b40fcaf5a763cd8e6da14
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7210 (2009)
Cross-presentation is now recognized as a major mechanism for initiating CD8 T cell responses to virus and tumor antigens in vivo. It provides an elegant mechanism that allows relatively few Dendritic cells (DCs) to initiate primary immune responses
Externí odkaz:
https://doaj.org/article/f008991366384ea298d296688d6391cc
Autor:
Delara Karkan, Cheryl Pfeifer, Timothy Z Vitalis, Gavin Arthur, Maki Ujiie, Qingqi Chen, Sam Tsai, Gerrasimo Koliatis, Reinhard Gabathuler, Wilfred A Jefferies
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2469 (2008)
BACKGROUND: Therapeutic intervention in many neurological diseases is thwarted by the physical obstacle formed by the blood-brain barrier (BBB) that excludes most drugs from entering the brain from the blood. Thus, identifying efficacious modes of dr
Externí odkaz:
https://doaj.org/article/97976960b78b4a45b2e503e66f593fb3
Autor:
Genc Basha, Gregory Lizée, Anna T Reinicke, Robyn P Seipp, Kyla D Omilusik, Wilfred A Jefferies
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3247 (2008)
BACKGROUND: Cross-presentation by dendritic cells (DCs) is a crucial prerequisite for effective priming of cytotoxic T-cell responses against bacterial, viral and tumor antigens; however, this antigen presentation pathway remains poorly defined. METH
Externí odkaz:
https://doaj.org/article/5783abe10b6c4f6dbad0b0857d88d54e
Autor:
Qian-Jin Zhang, Xiao-Lin Li, David Wang, Xiao-Cong Huang, J Michael Mathis, Wei-Ming Duan, David Knight, Runhua Shi, Jonathan Glass, Dong-Qing Zhang, Lea Eisenbach, Wilfred A Jefferies
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3097 (2008)
The transporter associated with antigen processing (TAP) and the major histocompatibility complex class I (MHC-I), two important components of the MHC-I antigen presentation pathway, are often deficient in tumor cells. The restoration of their expres
Externí odkaz:
https://doaj.org/article/69f176eae58c44cab05a4e0c8102a785
Autor:
Timothy Z Vitalis, Qian-Jin Zhang, Judie Alimonti, Susan S Chen, Genc Basha, Alex Moise, Jacqueline Tiong, Mei Mei Tian, Kyung Bok Choi, Douglas Waterfield, Andy Jeffries, Wilfred A Jefferies
Publikováno v:
PLoS Pathogens, Vol 1, Iss 4, p e36 (2005)
We hypothesize that over-expression of transporters associated with antigen processing (TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I antigen-processing pathway, enhances antigen-specific cytotoxic activity in respo
Externí odkaz:
https://doaj.org/article/a3faf129b9b9437ea34fcbba6e98e1fc