Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Wild type protein"'
Publikováno v:
Current Drug Discovery Technologies. 18:365-378
Diseases are often caused by mutant proteins. Many drugs have limited effectiveness and/or toxic side effects because of a failure to selectively target the disease-causing mutant variant, rather than the functional wild type protein. Otherwise, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526dc945181a66764818fe6b00163825
https://doi.org/10.2174/1570163817666200311114819
https://doi.org/10.2174/1570163817666200311114819
Autor:
Alexandra Moura, Paola Nocerino, Palma Mangione, Guglielmo Verona, Dorota Rowczenio, Diana Canetti, Graham W. Taylor, Nigel B. Rendell, Janet A. Gilbertson, Vittorio Bellotti, Julian D. Gillmore
Publikováno v:
Amyloid
Human lysozyme is a bacteriolytic enzyme synthesised by gastrointestinal (GI) tract macrophages and hepatocytes. It is found in many different tissues and body fluids including the liver, articular...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519d6c609f1f2d2e04ce28c4f25206e5
Publikováno v:
Chemistry Letters. 47:217-220
p53 acts as a transcriptional factor for tumor suppression via tetramerization. Although the dominant-negative effect occurs by hetero-oligomerization between wild-type and mutant p53, the precise mechanism remains unclear. Here, we report an analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4de3012d9d3958b57630655e3714d0f8
https://doi.org/10.1246/cl.170980
https://doi.org/10.1246/cl.170980
Publikováno v:
Matrix Biology Plus, Vol 2, Iss, Pp-(2019)
Matrix Biology Plus
Elsevier
Matrix Biology Plus
Elsevier
Elastin provides elastic tissues with resilience through stretch and recoil cycles, and is primarily made of itsextensively cross-linked monomer, tropoelastin. Here, we leverage the recently published full atomistic modelof tropoelastin to assess how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d5a7867d7cb2970127ad9368834874
http://www.sciencedirect.com/science/article/pii/S2590028519300018
http://www.sciencedirect.com/science/article/pii/S2590028519300018
Autor:
Alex Marcel Moreira Dias, Regina Célia Mingroni-Netto, Beatriz de Castro Andrade Mendes, Fernanda Stávale Nicastro, Karina Lezirovitz
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Mutations in the CEACAM6 gene were first described as causing autosomal dominant nonsyndromic hearing loss, but two splice-altering variants have been recently described as causing autosomal recessive nonsyndromic hearing loss. We describe the novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa373d43a7a8604d9b9c0a89b717a51
Autor:
Kristina Trujillo, Vered Wineman-Fisher, Dan Huppert, Yifat Miller, Ron Simkovich, S. James Remington
Publikováno v:
Physical Chemistry Chemical Physics. 18:23089-23095
Replacement of the hydroxyl group of a hydrophilic sidechain by an H atom in the proton wire of GFP induces formation of a water-chain proton wire. Surprisingly, this "non-native" water chain functions as a proton wire with response times within 10 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8157890c5cfa8951f0b1fcd85fdeb560
https://doi.org/10.1039/c6cp05071a
https://doi.org/10.1039/c6cp05071a
Autor:
Geoffrey J. Clark
Publikováno v:
Cancer Research. 80:6374-6374
The Ras oncoprotein may participate in driving half of human tumors and as such remains the single most significant therapeutic target in cancer. Attempts to develop targeted inhibitors of RAS have proved extremely challenging. We have developed a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616c1d679c88ea731a284522ed0c18e2
https://doi.org/10.1158/1538-7445.am2020-6374
https://doi.org/10.1158/1538-7445.am2020-6374
Autor:
Jose Antonio Reyes-Suarez, Ehmke Pohl, Raquel Quatrini, Jaime Henriquez, Braulio Valdebenito-Maturana, Mauricio Arenas-Salinas, David S. Holmes
Publikováno v:
Journal of computational chemistry, 2017, Vol.38(7), pp.467-474 [Peer Reviewed Journal]
The electrostatic potential plays a key role in many biological processes like determining the affinity of a ligand to a given protein target, and they are responsible for the catalytic activity of many enzymes. Understanding the effect that amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f1976757bb359a5bd81bb3117da363
http://dro.dur.ac.uk/22797/1/22797.pdf
http://dro.dur.ac.uk/22797/1/22797.pdf
Autor:
Sook Wern Chua, Lars M. Ittner, Michael Kassiou, Tristan A. Reekie, Renee Sokias, Erick C.N. Wong, Eryn L. Werry, Lenka Munoz
The 18 kDa translocator protein (TSPO) is a target for development of diagnostic imaging agents for glioblastoma and neuroinflammation. Clinical translation of TSPO imaging agents has been hindered by the presence of a polymorphism, rs6971, which cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d5ef87e27098fbb99c9a2e5be3db62
https://zenodo.org/record/291817
https://zenodo.org/record/291817
Publikováno v:
Pharmacological research. 117
A substantial number of G-protein coupled receptors (GPCRs) genetic disorders are due to mutations that cause misfolding or dysfunction of the receptor product. Pharmacological chaperoning approaches can rescue such mutant receptors by stabilizing pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b0bf8bf84710a343a8b490e0b4cccc
https://pubmed.ncbi.nlm.nih.gov/28027910
https://pubmed.ncbi.nlm.nih.gov/28027910