C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells.

Autor: Wilcock BC; Howard Hughes Medical Institute, Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA., Endo MM, Uno BE, Burke MD

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2013 Jun 12; Vol. 135 (23), pp. 8488-91. Date of Electronic Publication: 2013 Jun 03.

Amphotericin primarily kills yeast by simply binding ergosterol.

Autor: Gray KC; Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Feb 14; Vol. 109 (7), pp. 2234-9. Date of Electronic Publication: 2012 Jan 17.