Structure, function and selective inhibition of bacterial acetyl-coa carboxylase

Autor: Andrew D. Abell, Steven W. Polyak, Lixin Zhang, Matthew C.J. Wilce, Grant W. Booker

Publikováno v: Applied Microbiology and Biotechnology. 93:983-992

Acetyl-CoA carboxylase (ACC) catalyses the first committed step in fatty acid biosynthesis: a metabolic pathway required for several important biological processes including the synthesis and maintenance of cellular membranes. ACC employs a covalentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d0580377000d6bddb0b5c7441c8e87
https://doi.org/10.1007/s00253-011-3796-z

Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.

Autor: Gunzburg MJ; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton VIC 3800, Australia., Kulkarni K; School of Chemistry, Monash University, Wellington Road, Clayton VIC 3800, Australia., Watson GM; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton VIC 3800, Australia., Ambaye ND; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton VIC 3800, Australia., Del Borgo MP; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton VIC 3800, Australia., Brandt R; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton VIC 3800, Australia., Pero SC; Department of Surgery and Vermont Cancer Center, University of Vermont, Burlington 05401, USA., Perlmutter P; School of Chemistry, Monash University, Wellington Road, Clayton VIC 3800, Australia., Wilce MC; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton VIC 3800, Australia., Wilce JA; Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton VIC 3800, Australia.

Publikováno v: Scientific reports [Sci Rep] 2016 Jun 03; Vol. 6, pp. 27060. Date of Electronic Publication: 2016 Jun 03.

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module.

Autor: Selkrig J; 1] Department of Microbiology, Monash University, Clayton 3800, Australia [2] Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia., Belousoff MJ; Department of Microbiology, Monash University, Clayton 3800, Australia., Headey SJ; Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Heinz E; Department of Microbiology, Monash University, Clayton 3800, Australia., Shiota T; Department of Microbiology, Monash University, Clayton 3800, Australia., Shen HH; 1] Department of Microbiology, Monash University, Clayton 3800, Australia [2] Department of Materials Engineering, Monash University, Clayton 3800, Australia., Beckham SA; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia., Bamert RS; Department of Microbiology, Monash University, Clayton 3800, Australia., Phan MD; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia., Schembri MA; Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia., Wilce MC; Department of Biochemistry and Molecular Biology, Monash University, Clayton 3800, Australia., Scanlon MJ; Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia., Strugnell RA; Department of Microbiology &Immunology, University of Melbourne, Parkville 3052, Australia., Lithgow T; Department of Microbiology, Monash University, Clayton 3800, Australia.

Publikováno v: Scientific reports [Sci Rep] 2015 Aug 05; Vol. 5, pp. 12905. Date of Electronic Publication: 2015 Aug 05.

Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.

Autor: Salaemae W; School of Biological Sciences, The University of Adelaide, South Australia, 5005, Australia., Yap MY; Department of Biochemistry and Molecular Biology, School of Biomedical Science, Monash University, Victoria, 3800, Australia., Wegener KL; School of Biological Sciences, The University of Adelaide, South Australia, 5005, Australia., Booker GW; School of Biological Sciences, The University of Adelaide, South Australia, 5005, Australia., Wilce MC; Department of Biochemistry and Molecular Biology, School of Biomedical Science, Monash University, Victoria, 3800, Australia., Polyak SW; School of Biological Sciences, The University of Adelaide, South Australia, 5005, Australia. Electronic address: steven.polyak@adelaide.edu.au.

Publikováno v: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2015 May; Vol. 95 (3), pp. 259-66. Date of Electronic Publication: 2015 Mar 06.

X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein.

Autor: Don Paul C; Department of Neuro- and Sensory Physiology, University Medicine, Göttingen, 37073, Göttingen, Germany., Traore DA; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton campus, Victoria, 3800, Australia., Olsen S; School of Mathematics and Physics, The University of Queensland, Brisbane, Queensland, 4072, Australia., Devenish RJ; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton campus, Victoria, 3800, Australia., Close DW; Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, United States of America., Bell TD; School of Chemistry, Monash University, Clayton campus, Victoria, 3800, Australia., Bradbury A; Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, United States of America., Wilce MC; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton campus, Victoria, 3800, Australia., Prescott M; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton campus, Victoria, 3800, Australia.

Publikováno v: PloS one [PLoS One] 2015 Apr 29; Vol. 10 (4), pp. e0123338. Date of Electronic Publication: 2015 Apr 29 (Print Publication: 2015).