Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wilbur M. Song"'
Autor:
Nancy D. Marin, Michelle Becker-Hapak, Wilbur M. Song, Quazim A. Alayo, Lynne Marsala, Naomi Sonnek, Melissa M. Berrien-Elliott, Mark Foster, Jennifer A. Foltz, Jennifer Tran, Pamela Wong, Celia C. Cubitt, Patrick Pence, Kimberly Hwang, Alice Y. Zhou, Miriam T. Jacobs, Timothy Schappe, David A. Russler-Germain, Ryan C. Fields, Matthew A. Ciorba, Todd A. Fehniger
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTMetastatic (m) colorectal cancer (CRC) is an incurable disease with a poor prognosis and thus remains an unmet clinical need. Immune checkpoint blockade (ICB)-based immunotherapy is effective for mismatch repair-deficient (dMMR)/microsatellit
Externí odkaz:
https://doaj.org/article/989a296ad9bc48bf902f4f5ef1d3f555
Autor:
Yingyue Zhou, Wilbur M. Song, Prabhakar Andhey, Amanda Swain, Tyler Levy, Kelly R Miller, Pietro L. Poliani, Manuela Cominelli, Shikha Grover, Susan Gilfillan, Marina Cella, Tyler K Ulland, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Makoto Sainouchi, Akiyoshi Kakita, David A Bennett, Julie A Schneider, Michael R Nichols, Sean A Beausoleil, Jason Ulrich, David M Holtzman, Maxim Artyomov, Marco Colonna
Publikováno v:
Nature medicine
Alzheimer’s disease (AD) is the most common form of dementia that is initiated by extracellular plaque deposition and intraneuronal hyperphosphorylated tau aggregates. Reactive astrocytosis and microgliosis are secondary cellular responses to patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d07f6a73a56aa58325a309974ff812
http://europepmc.org/articles/PMC6980793
http://europepmc.org/articles/PMC6980793
Autor:
Marco Colonna, Konstantin Zaitsev, David M. Holtzman, Makoto Sainouchi, Manuela Cominelli, Akiyoshi Kakita, David A. Bennett, Susan Gilfillan, Marina Cella, Sean A. Beausoleil, Takeshi Ikeuchi, Tyler K. Ulland, Shikha Grover, Prabhakar S. Andhey, Kelly R. Miller, Michael R. Nichols, Tyler Levy, Julie A. Schneider, Wilbur M. Song, Amanda Swain, Jason D. Ulrich, Akinori Miyashita, Maxim N. Artyomov, Yingyue Zhou, Pietro Luigi Poliani
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TRE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f710a0b2b775974327693925d2167f3
http://hdl.handle.net/11379/533515
http://hdl.handle.net/11379/533515
Autor:
Wilbur M. Song, Marco Colonna
Publikováno v:
Nature Immunology. 19:1048-1058
The predominant type of immune cell in the brain is the microglia, a type of tissue-resident macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional profile, morphology and function in similar ways; thus, these a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93ef0124c360b58fd8343ea14d91f7d
https://doi.org/10.1038/s41590-018-0212-1
https://doi.org/10.1038/s41590-018-0212-1
Autor:
Marco Colonna, Yingyue Zhou, Tyler K. Ulland, Wilbur M. Song, Susan Gilfillan, Satoru Joshita
Publikováno v:
The Journal of Experimental Medicine
The R47H variant of the microglia gene TREM2 has been linked to a significantly higher risk of Alzheimer’s disease. In this study, Song et al. generate human TREM2-expressing mice and demonstrate that R47H leads to a decreased microglia number and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fef6f3bf259b532f8b45e9ad1774d42
http://europepmc.org/articles/PMC5839761
http://europepmc.org/articles/PMC5839761
Autor:
Marco Colonna, Wilbur M. Song
Publikováno v:
Cell. 172:3-5
Trained immunity is a form of innate immune memory with distinct features from classical adaptive immune memory. In the current issues of Cell and Cell Host & Microbe, five studies from the International Trained Immunity Consortium shed light on mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28aee6f8ad32bd0a04007d7465a769ec
https://doi.org/10.1016/j.cell.2017.12.034
https://doi.org/10.1016/j.cell.2017.12.034
Autor:
David M. Holtzman, Yaming Wang, Susan Gilfillan, Tyler K. Ulland, John A. Tzaferis, Thomas E. Mahan, Wilbur M. Song, Justin T. Hole, Jaime Grutzendler, Peng Yuan, Ronald B. DeMattos, Marco Colonna, Marina Cella, John R. Cirrito, Yang Shi, Jason D. Ulrich
Publikováno v:
The Journal of Experimental Medicine
Wang et al. report that TREM2 protects mice from Alzheimer's disease by enabling resident microglia to insulate and alter Aβ plaque structure, thereby limiting neuritic damage.
Triggering receptor expressed on myeloid cells 2 (TREM2) is a micro
Triggering receptor expressed on myeloid cells 2 (TREM2) is a micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e9c76abb1da46c864738f44834edbe
http://europepmc.org/articles/PMC4854736
http://europepmc.org/articles/PMC4854736
Autor:
Manuela Cominelli, Julie A. Schneider, Prabhakar S. Andhey, Sean A. Beausoleil, Michael R. Nichols, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Kelly R. Miller, Shikha Grover, Jason D. Ulrich, Tyler K. Ulland, Amanda Swain, Makoto Sainouchi, David A. Bennett, Yingyue Zhou, Maxim N. Artyomov, Pietro Luigi Poliani, Wilbur M. Song, David M. Holtzman, Susan Gilfillan, Akiyoshi Kakita, Marco Colonna, Tyler Levy, Marina Cella
Publikováno v:
Nature Medicine. 26:981-981
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d411afcfd95f37b6623512f934567926
https://doi.org/10.1038/s41591-020-0922-4
https://doi.org/10.1038/s41591-020-0922-4
Autor:
Wilbur M, Song, Marco, Colonna
Publikováno v:
Advances in immunology. 139
Microglia are a subset of tissue macrophages that constitute the major immune cell type of the central nervous system. These cells have long been known to change their morphology and functions in response to various neurological insults. Recently, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7e578262da7055c1abab3d9169dde2f
https://pubmed.ncbi.nlm.nih.gov/30249333
https://pubmed.ncbi.nlm.nih.gov/30249333
Autor:
Thomas E. Mahan, Jason D. Ulrich, Sofie Nyström, Floy R. Stewart, Yaming Wang, K. Peter R. Nilsson, David M. Holtzman, Mariska Reinartz, Hong Jiang, Yingyue Zhou, Elise Anderson, Seulah Choi, Tyler K. Ulland, Wilbur M. Song, Marco Colonna
Publikováno v:
Journal of Experimental Medicine, 215, 1047-1058
Journal of Experimental Medicine, 215, 4, pp. 1047-1058
The Journal of Experimental Medicine
Journal of Experimental Medicine, 215, 4, pp. 1047-1058
The Journal of Experimental Medicine
Increasing evidence suggests that apoE influences the innate immune response in neurodegeneration. Here, Ulrich et al. report that apoE influences amyloid plaque morphology and the microglial response to amyloid plaques, along with plaque-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dd66f8f8e352b4cc89fc8ff4f0ad4e
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150505
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-150505