A consensus research agenda for optimising nasal drug delivery

Autor: Pierre Lambert, Fabio Sonvico, Rene Bommer, Grazia Caivano, Marie Hellfritzsch, Wilbur de Kruijf, Francesca Schiaretti, Gerallt Williams, Marie Trenkel, Alain Regard, Laurent Vecellio, Regina Scherließ, Jonathan Goole, Ben Forbes

Publikováno v: Expert opinion on drug delivery
Expert Opinion on Drug Delivery
Expert Opinion on Drug Delivery, Taylor & Francis, 2020, 17 (2), pp.127-132. ⟨10.1080/17425247.2020.1714589⟩
Expert Opinion on Drug Delivery, 2020, 17 (2), pp.127-132. ⟨10.1080/17425247.2020.1714589⟩

Nasal drug delivery has specific challenges which are distinct from oral inhalation, alongside which it is often considered. The next generation of nasal products will be required to deliver new classes of molecule, e.g. vaccines, biologics and drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64181aedabda8e2ca2bf9e5e73136e1
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/300963

Inhalation delivery of complex drugs-the next steps

Autor: Carsten Ehrhardt, Wilbur de Kruijf

Publikováno v: Current opinion in pharmacology. 36

Oral inhalation offers the opportunity of targeting drugs locally to different regions of the respiratory tract or alternatively, using the high surface area of the alveoli for systemic delivery. Pulmozyme and the inhaled insulins (i.e. Exubera and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236ae0873df57c2eb472e4b09bfcd39a
https://pubmed.ncbi.nlm.nih.gov/28846876

In vivo performance testing of the novel Medspray wet aerosol inhaler

Autor: Jeroen Mathijn Wissink, Anne H. de Boer, Iwan Rutger Heskamp, Pieter Zanen, Wilbur de Kruijf, Paul Hagedoorn, Cees J.M. van Rijn, Henderik W. Frijlink, Paul Munnik

Publikováno v: Journal of aerosol medicine and pulmonary drug delivery, 22(4), 317-321. MARY ANN LIEBERT, INC
Journal of Aerosol Medicine and Pulmonary Drug Delivery 22 (2009) 4
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 22(4), 317-321

Background: Monodisperse salbutamol inhalers were compared to select the optimal mass median aerodynamic diameter: 4.0, 5.0 or 6.0 mu m.Methods: Fifteen mild asthmatic patients participated. In all a FEV(1)-response of >12% (vs. baseline) or >200 mL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4c0f3079f9bf455641c35812dc48d7
https://research.rug.nl/en/publications/0636b75f-906c-4ba8-a0d3-f21d4e0f3080

In Vitro Performance Testing of the Novel Medspray® Wet Aerosol Inhaler Based on the Principle of Rayleigh Break-up.

Autor: Anne de Boer, Jeroen Wissink, Paul Hagedoorn, Iwan Heskamp, Wilbur de Kruijf, Ralf Bünder, Pieter Zanen, Paul Munnik, Cees van Rijn, Henderik Frijlink

Publikováno v: Pharmaceutical Research; May2008, Vol. 25 Issue 5, p1186-1192, 7p