Single-cell RNAseq reveals seven classes of colonic sensory neuron

Autor: Hockley, James R F, Taylor, Toni S, Callejo, Gerard, Wilbrey, Anna L, Gutteridge, Alex, Bach, Karsten, Winchester, Wendy J, Bulmer, David C, McMurray, Gordon, Smith, Ewan St John

Publikováno v: Gut

OBJECTIVE: Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious sensation, but the divers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b887696d55b38db8efaa391fa9b38b01

Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways

Autor: Hockley, James RF, González-Cano, Rafael, McMurray, Sheridan, Tejada-Giraldez, Miguel A, McGuire, Cian, Torres, Antonio, Wilbrey, Anna L, Cibert-Goton, Vincent, Nieto, Francisco R, Pitcher, Thomas, Knowles, Charles H, Baeyens, José Manuel, Wood, John N, Winchester, Wendy J, Bulmer, David C, Cendán, Cruz Miguel, McMurray, Gordon

KEY POINTS: Voltage-gated sodium channels play a fundamental role in determining neuronal excitability. Specifically, voltage-gated sodium channel subtype NaV 1.7 is required for sensing acute and inflammatory somatic pain in mice and humans but its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5073f0d6ef727da37b8b8f7fa9884539
Wiley Online Library

Visceral and somatic pain modalities reveal NaV1.7-independent visceral nociceptive pathways.

Autor: Hockley, James R. F., González‐Cano, Rafael, McMurray, Sheridan, Tejada‐Giraldez, Miguel A., McGuire, Cian, Torres, Antonio, Wilbrey, Anna L., Cibert‐Goton, Vincent, Nieto, Francisco R., Pitcher, Thomas, Knowles, Charles H., Baeyens, José Manuel, Wood, John N., Winchester, Wendy J., Bulmer, David C., Cendán, Cruz Miguel, McMurray, Gordon

Publikováno v: Journal of Physiology; Apr2017, Vol. 595 Issue 8, p2661-2679, 19p

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Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1 ^-/- mice.

Autor: Gould SA; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK; The Babraham Institute, Cambridge, UK., White M; The Babraham Institute, Cambridge, UK; Department of Basic and Clinical Neuroscience, The Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London SE5 9RT, UK., Wilbrey AL; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Pór E; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Szeged, Szeged H-6724, Hungary., Coleman MP; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK; The Babraham Institute, Cambridge, UK., Adalbert R; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK; The Babraham Institute, Cambridge, UK; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Szeged, Szeged H-6724, Hungary. Electronic address: adalbert.janos.robert@med.u-szeged.hu.

Publikováno v: Experimental neurology [Exp Neurol] 2021 Apr; Vol. 338, pp. 113607. Date of Electronic Publication: 2021 Jan 15.